Gs alpha subunit

protein
Name=GNAS complex locus
caption=


width=
HGNCid=4392
Symbol=GNAS
AltSymbols=GNAS1
EntrezGene=2778
OMIM=139320
RefSeq=NM_000516
UniProt=Q5JWF2
PDB=
ECnumber=
Chromosome=20
Arm=q
Band=13.2
LocusSupplementaryData=-13.3The G_s alpha subunit (or Gs protein) is a heterotrimeric G protein subunit which activates adenylate cyclase. Researchers have discovered that a change in the location of this protein in the brain could serve as a biomarker for depression, allowing a simple, rapid, laboratory test to identify patients with depression. [ [http://www.reuters.com/article/blogBurst/health?bbPostId=Cz5Ev0JdU2gZtB5hCCYBscaP5B1Mv68LfBv2MBAJwR3XoLRgc Health Blog Posts powered by BlogBurst | Reuters.com ] ]

Receptors

The G-protein coupled receptors that couple to this kind of G-protein include:
* 5-HT receptors types H₄ and H₇
* ACTH receptor
* Adenosine receptor types A_2a and A_2b
* Arginine vasopressin receptor 2
* β-adrenergic receptors types β₁, β₂ and β₃
* Calcitonin receptor
* Calcitonin gene-related peptide receptor
* Corticotropin-releasing hormone receptor
* Dopamine receptors D₁-like family (D₁ and D₅)
* FSH-receptor
* Gastric inhibitory polypeptide receptor
* Glucagon receptor
* Histamine H₂ receptor
* Luteinizing hormone/choriogonadotropin receptor
* Melanocortin receptor
* Parathyroid hormone receptor 1
* Prostaglandin receptor types D₂ and I₂
* Secretin receptor
* Thyrotropin receptor

Function

The general function of G_s is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn activates cAMP-dependent protein kinase. Further effects of G_s is thus found in function of cAMP-dependent protein kinase.

ee also

* Second messenger system

External links

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References