Interleukin 5 receptor alpha subunit

Interleukin 5 receptor, alpha (IL5RA) also known as CD125 (Cluster of Differentiation 125) is a subunit of the Interleukin-5 receptor. IL5RA also denotes its human gene.cite web | title = Entrez Gene: IL5RA interleukin 5 receptor, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3568| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. The receptor is comprised of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL5 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. This protein has been found to interact with syndecan binding protein (syntenin), which is required for IL5 mediated activation of the transcription factor SOX4. Six alternatively spliced transcript variants encoding three distinct isoforms have been reported.cite web | title = Entrez Gene: IL5RA interleukin 5 receptor, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3568| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Isobe M, Kumura Y, Murata Y, "et al." |title=Localization of the gene encoding the alpha subunit of human interleukin-5 receptor (IL5RA) to chromosome region 3p24-3p26. |journal=Genomics |volume=14 |issue= 3 |pages= 755–8 |year= 1992 |pmid= 1427903 |doi=
*cite journal | author=Tuypens T, Plaetinck G, Baker E, "et al." |title=Organization and chromosomal localization of the human interleukin 5 receptor alpha-chain gene. |journal=Eur. Cytokine Netw. |volume=3 |issue= 5 |pages= 451–9 |year= 1993 |pmid= 1477296 |doi=
*cite journal | author=Tavernier J, Tuypens T, Plaetinck G, "et al." |title=Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 15 |pages= 7041–5 |year= 1992 |pmid= 1495999 |doi=
*cite journal | author=Scott HS, Guo XH, Hopwood JJ, Morris CP |title=Structure and sequence of the human alpha-L-iduronidase gene. |journal=Genomics |volume=13 |issue= 4 |pages= 1311–3 |year= 1992 |pmid= 1505961 |doi=
*cite journal | author=Murata Y, Takaki S, Migita M, "et al." |title=Molecular cloning and expression of the human interleukin 5 receptor. |journal=J. Exp. Med. |volume=175 |issue= 2 |pages= 341–51 |year= 1992 |pmid= 1732409 |doi=
*cite journal | author=Tavernier J, Devos R, Cornelis S, "et al." |title=A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific alpha chain and a beta chain shared with the receptor for GM-CSF. |journal=Cell |volume=66 |issue= 6 |pages= 1175–84 |year= 1991 |pmid= 1833065 |doi=
*cite journal | author=Johanson K, Appelbaum E, Doyle M, "et al." |title=Binding interactions of human interleukin 5 with its receptor alpha subunit. Large scale production, structural, and functional studies of Drosophila-expressed recombinant proteins. |journal=J. Biol. Chem. |volume=270 |issue= 16 |pages= 9459–71 |year= 1995 |pmid= 7721873 |doi=
*cite journal | author=Sun Z, Yergeau DA, Tuypens T, "et al." |title=Identification and characterization of a functional promoter region in the human eosinophil IL-5 receptor alpha subunit gene. |journal=J. Biol. Chem. |volume=270 |issue= 3 |pages= 1462–71 |year= 1995 |pmid= 7836416 |doi=
*cite journal | author=Hori K, Hirashima M, Ueno M, "et al." |title=Regulation of eosinophil migration by adult T cell leukemia-derived factor. |journal=J. Immunol. |volume=151 |issue= 10 |pages= 5624–30 |year= 1993 |pmid= 8228251 |doi=
*cite journal | author=Huston MM, Moore JP, Mettes HJ, "et al." |title=Human B cells express IL-5 receptor messenger ribonucleic acid and respond to IL-5 with enhanced IgM production after mitogenic stimulation with Moraxella catarrhalis. |journal=J. Immunol. |volume=156 |issue= 4 |pages= 1392–401 |year= 1996 |pmid= 8568239 |doi=
*cite journal | author=Monahan J, Siegel N, Keith R, "et al." |title=Attenuation of IL-5-mediated signal transduction, eosinophil survival, and inflammatory mediator release by a soluble human IL-5 receptor. |journal=J. Immunol. |volume=159 |issue= 8 |pages= 4024–34 |year= 1997 |pmid= 9378992 |doi=
*cite journal | author=Ogata N, Kouro T, Yamada A, "et al." |title=JAK2 and JAK1 constitutively associate with an interleukin-5 (IL-5) receptor alpha and betac subunit, respectively, and are activated upon IL-5 stimulation. |journal=Blood |volume=91 |issue= 7 |pages= 2264–71 |year= 1998 |pmid= 9516124 |doi=
*cite journal | author=Tavernier J, Van der Heyden J, Verhee A, "et al." |title=Interleukin 5 regulates the isoform expression of its own receptor alpha-subunit. |journal=Blood |volume=95 |issue= 5 |pages= 1600–7 |year= 2000 |pmid= 10688814 |doi=
*cite journal | author=Czabotar PE, Holland J, Sanderson CJ |title=Identification of regions within the third FnIII-like domain of the IL-5Ralpha involved in IL-5 interaction. |journal=Cytokine |volume=12 |issue= 7 |pages= 867–73 |year= 2000 |pmid= 10880230 |doi= 10.1006/cyto.1999.0663
*cite journal | author=Plugariu CG, Wu SJ, Zhang W, Chaiken I |title=Multisite mutagenesis of interleukin 5 differentiates sites for receptor recognition and receptor activation. |journal=Biochemistry |volume=39 |issue= 48 |pages= 14939–49 |year= 2001 |pmid= 11101310 |doi=
*cite journal | author=Geijsen N, Uings IJ, Pals C, "et al." |title=Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein. |journal=Science |volume=293 |issue= 5532 |pages= 1136–8 |year= 2001 |pmid= 11498591 |doi= 10.1126/science.1059157
*cite journal | author=Upham JW, Sehmi R, Hayes LM, "et al." |title=Retinoic acid modulates IL-5 receptor expression and selectively inhibits eosinophil-basophil differentiation of hemopoietic progenitor cells. |journal=J. Allergy Clin. Immunol. |volume=109 |issue= 2 |pages= 307–13 |year= 2002 |pmid= 11842302 |doi=
*cite journal | author=Rizzo CA, Yang R, Greenfeder S, "et al." |title=The IL-5 receptor on human bronchus selectively primes for hyperresponsiveness. |journal=J. Allergy Clin. Immunol. |volume=109 |issue= 3 |pages= 404–9 |year= 2002 |pmid= 11897983 |doi=
*cite journal | author=Scibek JJ, Evergren E, Zahn S, "et al." |title=Biosensor analysis of dynamics of interleukin 5 receptor subunit beta(c) interaction with IL5:IL5R(alpha) complexes. |journal=Anal. Biochem. |volume=307 |issue= 2 |pages= 258–65 |year= 2003 |pmid= 12202242 |doi=
*cite journal | author=Liu LY, Sedgwick JB, Bates ME, "et al." |title=Decreased expression of membrane IL-5 receptor alpha on human eosinophils: I. Loss of membrane IL-5 receptor alpha on airway eosinophils and increased soluble IL-5 receptor alpha in the airway after allergen challenge. |journal=J. Immunol. |volume=169 |issue= 11 |pages= 6452–8 |year= 2002 |pmid= 12444154 |doi=

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes