Interleukin 27 receptor, alpha subunit

Interleukin 27 receptor, alpha is a subunit of the interleukin-27 receptor. IL27RA is its human gene.cite web | title = Entrez Gene: IL27RA interleukin 27 receptor, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9466| accessdate = ]

PBB_Summary
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summary_text = In mice, CD4+ helper T-cells differentiate into type 1 (Th1) cells, which are critical for cell-mediated immunity, predominantly under the influence of IL12. Also, IL4 influences their differentiation into type 2 (Th2) cells, which are critical for most antibody responses. Mice deficient in these cytokines, their receptors, or associated transcription factors have impaired, but are not absent of, Th1 or Th2 immune responses. This gene encodes a protein which is similar to the mouse T-cell cytokine receptor Tccr at the amino acid level, and is predicted to be a glycosylated transmembrane protein.cite web | title = Entrez Gene: IL27RA interleukin 27 receptor, alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9466| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sprecher CA, Grant FJ, Baumgartner JW, "et al." |title=Cloning and characterization of a novel class I cytokine receptor. |journal=Biochem. Biophys. Res. Commun. |volume=246 |issue= 1 |pages= 82–90 |year= 1998 |pmid= 9600072 |doi= 10.1006/bbrc.1998.8576
*cite journal | author=Chen Q, Ghilardi N, Wang H, "et al." |title=Development of Th1-type immune responses requires the type I cytokine receptor TCCR. |journal=Nature |volume=407 |issue= 6806 |pages= 916–20 |year= 2000 |pmid= 11057672 |doi= 10.1038/35038103
*cite journal | author=Pflanz S, Timans JC, Cheung J, "et al." |title=IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4(+) T cells. |journal=Immunity |volume=16 |issue= 6 |pages= 779–90 |year= 2002 |pmid= 12121660 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Takeda A, Hamano S, Yamanaka A, "et al." |title=Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. |journal=J. Immunol. |volume=170 |issue= 10 |pages= 4886–90 |year= 2003 |pmid= 12734330 |doi=
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Pflanz S, Hibbert L, Mattson J, "et al." |title=WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. |journal=J. Immunol. |volume=172 |issue= 4 |pages= 2225–31 |year= 2004 |pmid= 14764690 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Pradhan A, Lambert QT, Reuther GW |title=Transformation of hematopoietic cells and activation of JAK2-V617F by IL-27R, a component of a heterodimeric type I cytokine receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 47 |pages= 18502–7 |year= 2008 |pmid= 18003935 |doi= 10.1073/pnas.0702388104

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