KCNA4

Potassium voltage-gated channel, shaker-related subfamily, member 4, also known as KCNA4 or K_v1.4, is a human gene.cite web | title = Entrez Gene: KCNA4 potassium voltage-gated channel, shaker-related subfamily, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3739| accessdate = ]

PBB_Summary
section_title =
summary_text = Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the A-type potassium current class, the members of which may be important in the regulation of the fast repolarizing phase of action potentials in heart and thus may influnce the duration of cardiac action potential. The coding region of this gene is intronless, and the gene is clustered with genes KCNA3 and KCNA10 on chromosome 1.cite web | title = Entrez Gene: KCNA4 potassium voltage-gated channel, shaker-related subfamily, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3739| accessdate = ]

ee also

* Voltage-gated potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gutman GA, Chandy KG, Grissmer S, "et al." |title=International Union of Pharmacology. LIII. Nomenclature and molecular relationships of voltage-gated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 473–508 |year= 2006 |pmid= 16382104 |doi= 10.1124/pr.57.4.10
*cite journal | author=Scott HS, Litjens T, Hopwood JJ, Morris CP |title=PCR detection of two RFLPs in exon I of the alpha-L-iduronidase (IDUA) gene. |journal=Hum. Genet. |volume=90 |issue= 3 |pages= 327 |year= 1993 |pmid= 1362562 |doi=
*cite journal | author=Gessler M, Grupe A, Grzeschik KH, Pongs O |title=The potassium channel gene HK1 maps to human chromosome 11p14.1, close to the FSHB gene. |journal=Hum. Genet. |volume=90 |issue= 3 |pages= 319–21 |year= 1993 |pmid= 1487251 |doi=
*cite journal | author=Philipson LH, Hice RE, Schaefer K, "et al." |title=Sequence and functional expression in Xenopus oocytes of a human insulinoma and islet potassium channel. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 1 |pages= 53–7 |year= 1991 |pmid= 1986382 |doi=
*cite journal | author=Tamkun MM, Knoth KM, Walbridge JA, "et al." |title=Molecular cloning and characterization of two voltage-gated K+ channel cDNAs from human ventricle. |journal=FASEB J. |volume=5 |issue= 3 |pages= 331–7 |year= 1991 |pmid= 2001794 |doi=
*cite journal | author=Philipson LH, Schaefer K, LaMendola J, "et al." |title=Sequence of a human fetal skeletal muscle potassium channel cDNA related to RCK4. |journal=Nucleic Acids Res. |volume=18 |issue= 23 |pages= 7160 |year= 1991 |pmid= 2263489 |doi=
*cite journal | author=Kim E, Niethammer M, Rothschild A, "et al." |title=Clustering of Shaker-type K+ channels by interaction with a family of membrane-associated guanylate kinases. |journal=Nature |volume=378 |issue= 6552 |pages= 85–8 |year= 1995 |pmid= 7477295 |doi= 10.1038/378085a0
*cite journal | author=Klocke R, Roberds SL, Tamkun MM, "et al." |title=Chromosomal mapping in the mouse of eight K(+)-channel genes representing the four Shaker-like subfamilies Shaker, Shab, Shaw, and Shal. |journal=Genomics |volume=18 |issue= 3 |pages= 568–74 |year= 1994 |pmid= 7905852 |doi=
*cite journal | author=Philipson LH, Eddy RL, Shows TB, Bell GI |title=Assignment of human potassium channel gene KCNA4 (Kv1.4, PCN2) to chromosome 11q13.4-->q14.1. |journal=Genomics |volume=15 |issue= 2 |pages= 463–4 |year= 1993 |pmid= 8449523 |doi= 10.1006/geno.1993.1094
*cite journal | author=Niethammer M, Kim E, Sheng M |title=Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases. |journal=J. Neurosci. |volume=16 |issue= 7 |pages= 2157–63 |year= 1996 |pmid= 8601796 |doi=
*cite journal | author=Kim E, Sheng M |title=Differential K+ channel clustering activity of PSD-95 and SAP97, two related membrane-associated putative guanylate kinases. |journal=Neuropharmacology |volume=35 |issue= 7 |pages= 993–1000 |year= 1997 |pmid= 8938729 |doi=
*cite journal | author=Kim E, Naisbitt S, Hsueh YP, "et al." |title=GKAP, a novel synaptic protein that interacts with the guanylate kinase-like domain of the PSD-95/SAP90 family of channel clustering molecules. |journal=J. Cell Biol. |volume=136 |issue= 3 |pages= 669–78 |year= 1997 |pmid= 9024696 |doi=
*cite journal | author=Niethammer M, Valtschanoff JG, Kapoor TM, "et al." |title=CRIPT, a novel postsynaptic protein that binds to the third PDZ domain of PSD-95/SAP90. |journal=Neuron |volume=20 |issue= 4 |pages= 693–707 |year= 1998 |pmid= 9581762 |doi=
*cite journal | author=Brenman JE, Topinka JR, Cooper EC, "et al." |title=Localization of postsynaptic density-93 to dendritic microtubules and interaction with microtubule-associated protein 1A. |journal=J. Neurosci. |volume=18 |issue= 21 |pages= 8805–13 |year= 1998 |pmid= 9786987 |doi=
*cite journal | author=Coleman SK, Newcombe J, Pryke J, Dolly JO |title=Subunit composition of Kv1 channels in human CNS. |journal=J. Neurochem. |volume=73 |issue= 2 |pages= 849–58 |year= 1999 |pmid= 10428084 |doi=
*cite journal | author=D'Adamo MC, Imbrici P, Sponcichetti F, Pessia M |title=Mutations in the KCNA1 gene associated with episodic ataxia type-1 syndrome impair heteromeric voltage-gated K(+) channel function. |journal=FASEB J. |volume=13 |issue= 11 |pages= 1335–45 |year= 1999 |pmid= 10428758 |doi=
*cite journal | author=Hogan A, Shepherd L, Chabot J, "et al." |title=Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions. |journal=J. Biol. Chem. |volume=276 |issue= 28 |pages= 26526–33 |year= 2001 |pmid= 11352924 |doi= 10.1074/jbc.M104156200
*cite journal | author=Cukovic D, Lu GW, Wible B, "et al." |title=A discrete amino terminal domain of Kv1.5 and Kv1.4 potassium channels interacts with the spectrin repeats of alpha-actinin-2. |journal=FEBS Lett. |volume=498 |issue= 1 |pages= 87–92 |year= 2001 |pmid= 11389904 |doi=
*cite journal | author=Imamura F, Maeda S, Doi T, Fujiyoshi Y |title=Ligand binding of the second PDZ domain regulates clustering of PSD-95 with the Kv1.4 potassium channel. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3640–6 |year= 2002 |pmid= 11723117 |doi= 10.1074/jbc.M106940200
*cite journal | author=Piserchio A, Pellegrini M, Mehta S, "et al." |title=The PDZ1 domain of SAP90. Characterization of structure and binding. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 6967–73 |year= 2002 |pmid= 11744724 |doi= 10.1074/jbc.M109453200

External links

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