KCNN4

Potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4, also known as KCNN4, is a human gene.cite web | title = Entrez Gene: KCNN4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3783| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily.cite web | title = Entrez Gene: KCNN4 potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3783| accessdate = ]

ee also

* SK channel
* Voltage-gated potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wei AD, Gutman GA, Aldrich R, "et al." |title=International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels. |journal=Pharmacol. Rev. |volume=57 |issue= 4 |pages= 463–72 |year= 2006 |pmid= 16382103 |doi= 10.1124/pr.57.4.9
*cite journal | author=Ishii TM, Silvia C, Hirschberg B, "et al." |title=A human intermediate conductance calcium-activated potassium channel. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 21 |pages= 11651–6 |year= 1997 |pmid= 9326665 |doi=
*cite journal | author=Joiner WJ, Wang LY, Tang MD, Kaczmarek LK |title=hSK4, a member of a novel subfamily of calcium-activated potassium channels. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 20 |pages= 11013–8 |year= 1997 |pmid= 9380751 |doi=
*cite journal | author=Logsdon NJ, Kang J, Togo JA, "et al." |title=A novel gene, hKCa4, encodes the calcium-activated potassium channel in human T lymphocytes. |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 32723–6 |year= 1998 |pmid= 9407042 |doi=
*cite journal | author=Ghanshani S, Coleman M, Gustavsson P, "et al." |title=Human calcium-activated potassium channel gene KCNN4 maps to chromosome 19q13.2 in the region deleted in diamond-blackfan anemia. |journal=Genomics |volume=51 |issue= 1 |pages= 160–1 |year= 1998 |pmid= 9693050 |doi= 10.1006/geno.1998.5333
*cite journal | author=Fanger CM, Ghanshani S, Logsdon NJ, "et al." |title=Calmodulin mediates calcium-dependent activation of the intermediate conductance KCa channel, IKCa1. |journal=J. Biol. Chem. |volume=274 |issue= 9 |pages= 5746–54 |year= 1999 |pmid= 10026195 |doi=
*cite journal | author=Liu QH, Williams DA, McManus C, "et al." |title=HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 9 |pages= 4832–7 |year= 2000 |pmid= 10758170 |doi= 10.1073/pnas.090521697
*cite journal | author=Ghanshani S, Wulff H, Miller MJ, "et al." |title=Up-regulation of the IKCa1 potassium channel during T-cell activation. Molecular mechanism and functional consequences. |journal=J. Biol. Chem. |volume=275 |issue= 47 |pages= 37137–49 |year= 2001 |pmid= 10961988 |doi= 10.1074/jbc.M003941200
*cite journal | author=Wulff H, Gutman GA, Cahalan MD, Chandy KG |title=Delineation of the clotrimazole/TRAM-34 binding site on the intermediate conductance calcium-activated potassium channel, IKCa1. |journal=J. Biol. Chem. |volume=276 |issue= 34 |pages= 32040–5 |year= 2001 |pmid= 11425865 |doi= 10.1074/jbc.M105231200
*cite journal | author=Koegel H, Kaesler S, Burgstahler R, "et al." |title=Unexpected down-regulation of the hIK1 Ca2+-activated K+ channel by its opener 1-ethyl-2-benzimidazolinone in HaCaT keratinocytes. Inverse effects on cell growth and proliferation. |journal=J. Biol. Chem. |volume=278 |issue= 5 |pages= 3323–30 |year= 2003 |pmid= 12421833 |doi= 10.1074/jbc.M208914200
*cite journal | author=Mazzone JN, Kaiser RA, Buxton IL |title=Calcium-activated potassium channel expression in human myometrium: effect of pregnancy. |journal=Proc. West. Pharmacol. Soc. |volume=45 |issue= |pages= 184–6 |year= 2003 |pmid= 12434576 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Syme CA, Hamilton KL, Jones HM, "et al." |title=Trafficking of the Ca2+-activated K+ channel, hIK1, is dependent upon a C-terminal leucine zipper. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8476–86 |year= 2003 |pmid= 12493744 |doi= 10.1074/jbc.M210072200
*cite journal | author=Hamilton KL, Syme CA, Devor DC |title=Molecular localization of the inhibitory arachidonic acid binding site to the pore of hIK1. |journal=J. Biol. Chem. |volume=278 |issue= 19 |pages= 16690–7 |year= 2003 |pmid= 12609997 |doi= 10.1074/jbc.M212959200
*cite journal | author=Mall M, Gonska T, Thomas J, "et al." |title=Modulation of Ca2+-activated Cl- secretion by basolateral K+ channels in human normal and cystic fibrosis airway epithelia. |journal=Pediatr. Res. |volume=53 |issue= 4 |pages= 608–18 |year= 2003 |pmid= 12612194 |doi= 10.1203/01.PDR.0000057204.51420.DC
*cite journal | author=Hoffman JF, Joiner W, Nehrke K, "et al." |title=The hSK4 (KCNN4) isoform is the Ca2+-activated K+ channel (Gardos channel) in human red blood cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 12 |pages= 7366–71 |year= 2003 |pmid= 12773623 |doi= 10.1073/pnas.1232342100
*cite journal | author=Bernard K, Bogliolo S, Soriani O, Ehrenfeld J |title=Modulation of calcium-dependent chloride secretion by basolateral SK4-like channels in a human bronchial cell line. |journal=J. Membr. Biol. |volume=196 |issue= 1 |pages= 15–31 |year= 2004 |pmid= 14724753 |doi= 10.1007/s00232-003-0621-3
*cite journal | author=Jones HM, Hamilton KL, Papworth GD, "et al." |title=Role of the NH2 terminus in the assembly and trafficking of the intermediate conductance Ca2+-activated K+ channel hIK1. |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 15531–40 |year= 2004 |pmid= 14754884 |doi= 10.1074/jbc.M400069200
*cite journal | author=Gibson JS, Muzyamba MC |title=Modulation of Gardos channel activity by oxidants and oxygen tension: effects of 1-chloro-2,4-dinitrobenzene and phenazine methosulphate. |journal=Bioelectrochemistry (Amsterdam, Netherlands) |volume=62 |issue= 2 |pages= 147–52 |year= 2005 |pmid= 15039018 |doi= 10.1016/j.bioelechem.2003.07.008
*cite journal | author=Lew VL, Tiffert T, Etzion Z, "et al." |title=Distribution of dehydration rates generated by maximal Gardos-channel activation in normal and sickle red blood cells. |journal=Blood |volume=105 |issue= 1 |pages= 361–7 |year= 2005 |pmid= 15339840 |doi= 10.1182/blood-2004-01-0125

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