KCNAB2

Potassium voltage-gated channel, shaker-related subfamily, beta member 2, also known as KCNAB2, is a human gene.cite web | title = Entrez Gene: KCNAB2 potassium voltage-gated channel, shaker-related subfamily, beta member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8514| accessdate = ]

PBB_Summary
section_title =
summary_text = Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member is one of the beta subunits, which are auxiliary proteins associating with functional Kv-alpha subunits. This member alters functional properties of the KCNA4 gene product. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.cite web | title = Entrez Gene: KCNAB2 potassium voltage-gated channel, shaker-related subfamily, beta member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8514| accessdate = ]

ee also

* Voltage-gated potassium channel

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=McCormack K, McCormack T, Tanouye M, "et al." |title=Alternative splicing of the human Shaker K+ channel beta 1 gene and functional expression of the beta 2 gene product. |journal=FEBS Lett. |volume=370 |issue= 1-2 |pages= 32–6 |year= 1995 |pmid= 7649300 |doi=
*cite journal | author=McCormack T, McCormack K |title=Shaker K+ channel beta subunits belong to an NAD(P)H-dependent oxidoreductase superfamily. |journal=Cell |volume=79 |issue= 7 |pages= 1133–5 |year= 1995 |pmid= 8001150 |doi=
*cite journal | author=Nakahira K, Shi G, Rhodes KJ, Trimmer JS |title=Selective interaction of voltage-gated K+ channel beta-subunits with alpha-subunits. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 7084–9 |year= 1996 |pmid= 8636142 |doi=
*cite journal | author=Schultz D, Litt M, Smith L, "et al." |title=Localization of two potassium channel beta subunit genes, KCNA1B and KCNA2B. |journal=Genomics |volume=31 |issue= 3 |pages= 389–91 |year= 1997 |pmid= 8838324 |doi= 10.1006/geno.1996.0065
*cite journal | author=Kääb S, Dixon J, Duc J, "et al." |title=Molecular basis of transient outward potassium current downregulation in human heart failure: a decrease in Kv4.3 mRNA correlates with a reduction in current density. |journal=Circulation |volume=98 |issue= 14 |pages= 1383–93 |year= 1998 |pmid= 9760292 |doi=
*cite journal | author=Coleman SK, Newcombe J, Pryke J, Dolly JO |title=Subunit composition of Kv1 channels in human CNS. |journal=J. Neurochem. |volume=73 |issue= 2 |pages= 849–58 |year= 1999 |pmid= 10428084 |doi=
*cite journal | author=Poliak S, Gollan L, Martinez R, "et al." |title=Caspr2, a new member of the neurexin superfamily, is localized at the juxtaparanodes of myelinated axons and associates with K+ channels. |journal=Neuron |volume=24 |issue= 4 |pages= 1037–47 |year= 2000 |pmid= 10624965 |doi=
*cite journal | author=Croci C, Brändstatter JH, Enz R |title=ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 6128–35 |year= 2003 |pmid= 12431995 |doi= 10.1074/jbc.M205162200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gu C, Jan YN, Jan LY |title=A conserved domain in axonal targeting of Kv1 (Shaker) voltage-gated potassium channels. |journal=Science |volume=301 |issue= 5633 |pages= 646–9 |year= 2003 |pmid= 12893943 |doi= 10.1126/science.1086998
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rush J, Moritz A, Lee KA, "et al." |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032

External links

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