- Gi alpha subunit
protein
Name = guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
caption =
width =
HGNCid = 4384
Symbol =GNAI1
AltSymbols =
EntrezGene = 2770
OMIM = 139310
RefSeq = NM_002069
UniProt = P63096
PDB =
ECnumber =
Chromosome = 7
Arm = q
Band = 21
LocusSupplementaryData = -q22protein
Name = guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
caption =
width =
HGNCid = 4385
Symbol =GNAI2
AltSymbols = GNAI2B
EntrezGene = 2771
OMIM = 139360
RefSeq = NM_002070
UniProt = P04899
PDB =
ECnumber =
Chromosome = 3
Arm = p
Band = 21
LocusSupplementaryData = protein
Name = guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
caption =
width =
HGNCid = 4387
Symbol =GNAI3
AltSymbols =
EntrezGene = 2773
OMIM = 139370
RefSeq = NM_006496
UniProt = P08754
PDB =
ECnumber =
Chromosome = 1
Arm = p
Band = 13
LocusSupplementaryData =Gi alpha subunit (or Gi/G0 or Gi protein) is a
heterotrimeric G protein subunit which inhibits the production of cAMP from ATP.cite journal | author = Birnbaumer L | title = Expansion of signal transduction by G proteins. The second 15 years or so: from 3 to 16 alpha subunits plus betagamma dimers | journal = Biochim. Biophys. Acta | volume = 1768 | issue = 4 | pages = 772–93 | year = 2007 | month = April | pmid = 17258171 | pmc = 1993906 | doi = 10.1016/j.bbamem.2006.12.002 | url = | issn = ]Receptors
The following
G-protein coupled receptors couple to the Gi subunit:
*5-HT receptor type 1
*Adenosine receptor A1 and A3
*Prostaglandins
* D2-like dopamine receptors
*CXCR4 Function
"See also:
function of cAMP-dependent protein kinase "Gi inhibits the production of cAMP from ATP, which, in turn, results in decreased activity of
cAMP-dependent protein kinase . Thus, the ultimate effect of Gi is thus the opposite of cAMP-dependent protein kinase, which can be found atfunction of cAMP-dependent protein kinase .Types
There are several types of Gi: Gia1, Gia2, Gia3 and Gia4
Gia1
Gia1 or Gi1 is encoded by the gene
GNAI1 .Gia2
Gia2 or Gi2 is encoded by the gene
GNAI2 .Gia3
Gia3 or Gi3 is encoded by the gene
GNAI3 .ee also
*
Second messenger system References
External links
*
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