Prostaglandin D2 receptor

Prostaglandin D2 receptor (DP)
Identifiers
Symbols	PTGDR; AS1; ASRT1; DP; DP1; MGC49004
External IDs	OMIM: 604687 MGI: 102966 HomoloGene: 736 IUPHAR: DP1 GeneCards: PTGDR Gene
Gene Ontology Molecular function • prostaglandin J receptor activity • receptor activity • G-protein coupled receptor activity • prostaglandin D receptor activity • protein binding Cellular component • plasma membrane • plasma membrane • plasma membrane • integral to membrane Biological process • G-protein coupled receptor protein signaling pathway • male sex determination • sleep • adenosine metabolic process • cellular response to prostaglandin D stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5729	19214
Ensembl	ENSG00000168229	ENSMUSG00000071489
UniProt	Q13258	Q8CCM3
RefSeq (mRNA)	NM_000953.2	NM_008962.4
RefSeq (protein)	NP_000944.1	NP_032988.3
Location (UCSC)	Chr 14: 52.73 – 52.74 Mb	Chr 14: 45.47 – 45.48 Mb
PubMed search	[1]	[2]

Prostaglandin D₂ receptor (DP₁) is a G-protein coupled receptor, encoded by the PTGDR gene, for prostaglandin D₂.^[1]

Mechanism

DP₁ is a G-protein-coupled receptor. Its activity is mainly mediated by G-S proteins that stimulate adenylate cyclase resulting in an elevation of intracellular cAMP and Ca²⁺.

Function

Knockout studies in mice suggest that the ligand of this receptor, prostaglandin D₂ (PGD₂), functions as a mast cell-derived mediator to trigger asthmatic responses.^[1] It also causes vasodilation

See also

• Eicosanoid receptor

References

1. ^ ^{a b} "Entrez Gene: PTGDR prostaglandin D2 receptor (DP)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5729. 

External links

• "Prostanoid Receptors: DP₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2414. 

Further reading

• Boyce JA (2004). "The role of mast cells in asthma". Prostaglandins Leukot. Essent. Fatty Acids 69 (2–3): 195–205. doi:10.1016/S0952-3278(03)00081-4. PMID 12895603. 
• Chiba T, Kanda A, Ueki S, et al. (2007). "Possible novel receptor for PGD2 on human bronchial epithelial cells". Int. Arch. Allergy Immunol. 143 Suppl 1: 23–7. doi:10.1159/000101400. PMID 17541272. 
• Senior J, Sangha R, Baxter GS, et al. (1992). "In vitro characterization of prostanoid FP-, DP-, IP- and TP-receptors on the non-pregnant human myometrium". Br. J. Pharmacol. 107 (1): 215–21. PMC 1907618. PMID 1422574. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1907618. 
• Boie Y, Sawyer N, Slipetz DM, et al. (1995). "Molecular cloning and characterization of the human prostanoid DP receptor". J. Biol. Chem. 270 (32): 18910–6. doi:10.1074/jbc.270.32.18910. PMID 7642548. 
• Ishikawa TO, Tamai Y, Rochelle JM, et al. (1997). "Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors". Genomics 32 (2): 285–8. doi:10.1006/geno.1996.0118. PMID 8833158. 
• Kobayashi T, Ushikubi F, Narumiya S (2000). "Amino acid residues conferring ligand binding properties of prostaglandin I and prostaglandin D receptors. Identification by site-directed mutagenesis". J. Biol. Chem. 275 (32): 24294–303. doi:10.1074/jbc.M002437200. PMID 10827082. 
• Wright DH, Ford-Hutchinson AW, Chadee K, Metters KM (2001). "The human prostanoid DP receptor stimulates mucin secretion in LS174T cells". Br. J. Pharmacol. 131 (8): 1537–45. doi:10.1038/sj.bjp.0703688. PMC 1572485. PMID 11139429. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1572485. 
• Gervais FG, Cruz RP, Chateauneuf A, et al. (2002). "Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP". J. Allergy Clin. Immunol. 108 (6): 982–8. doi:10.1067/mai.2001.119919. PMID 11742277. 
• Noguchi E, Shibasaki M, Kamioka M, et al. (2002). "New polymorphisms of haematopoietic prostaglandin D synthase and human prostanoid DP receptor genes". Clin. Exp. Allergy 32 (1): 93–6. doi:10.1046/j.0022-0477.2001.01261.x. PMID 12002745. 
• Hakonarson H, Bjornsdottir US, Halapi E, et al. (2002). "A Major Susceptibility Gene for Asthma Maps to Chromosome 14q24". Am. J. Hum. Genet. 71 (3): 483–91. doi:10.1086/342205. PMC 379187. PMID 12119603. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=379187. 
• Iwasaki M, Nagata K, Takano S, et al. (2002). "Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis". J. Invest. Dermatol. 119 (3): 609–16. doi:10.1046/j.1523-1747.2002.01862.x. PMID 12230502. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Moreland RB, Nehra A, Kim NN, et al. (2003). "Expression of functional prostaglandin D (DP) receptors in human corpus cavernosum smooth muscle". Int. J. Impot. Res. 14 (6): 446–52. doi:10.1038/sj.ijir.3900900. PMID 12494276. 
• Faveeuw C, Gosset P, Bureau F, et al. (2003). "Prostaglandin D2 inhibits the production of interleukin-12 in murine dendritic cells through multiple signaling pathways". Eur. J. Immunol. 33 (4): 889–98. doi:10.1002/eji.200323330. PMID 12672054. 
• Angeli V, Staumont D, Charbonnier AS, et al. (2004). "Activation of the D prostanoid receptor 1 regulates immune and skin allergic responses". J. Immunol. 172 (6): 3822–9. PMID 15004188. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Oguma T, Palmer LJ, Birben E, et al. (2004). "Role of prostanoid DP receptor variants in susceptibility to asthma". N. Engl. J. Med. 351 (17): 1752–63. doi:10.1056/NEJMoa031785. PMID 15496624. 
• Spik I, Brénuchon C, Angéli V, et al. (2005). "Activation of the prostaglandin D2 receptor DP2/CRTH2 increases allergic inflammation in mouse". J. Immunol. 174 (6): 3703–8. PMID 15749909. 
• Hirano Y, Shichijo M, Deguchi M, et al. (2007). "Synergistic effect of PGD2 via prostanoid DP receptor on TNF-alpha-induced production of MCP-1 and IL-8 in human monocytic THP-1 cells". Eur. J. Pharmacol. 560 (1): 81–8. doi:10.1016/j.ejphar.2007.01.003. PMID 17307163. 

Metabolites and
signaling molecules

Eicosanoid	CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other	Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate

Peptide

Neuropeptide	B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other	Anaphylatoxin (C3a, C5a) · Angiotensin (1, 2) · Apelin · Bombesin (BRS3, GRPR, NMBR) · Bradykinin (B1, B2) · Chemokine · Cholecystokinin (A, B) · Endothelin (A, B) · Formyl peptide (1, 2, 3) · FSH · Galanin (1, 2, 3) · GHB receptor · Gonadotropin-releasing hormone (1, 2) · Ghrelin · Kisspeptin · Luteinizing hormone/choriogonadotropin · MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortin (1, 2, 3, 4, 5) · MCHR (1, 2) · Motilin · Opioid (Delta, Kappa, Mu, Nociceptin & Zeta, but not Sigma) · Orexin (1, 2) · Oxytocin · Prokineticin (1, 2) · Prolactin-releasing peptide · Relaxin (1, 2, 3, 4) · Somatostatin (1, 2, 3, 4, 5) · Tachykinin (1, 2, 3) · Thyrotropin · Thyrotropin-releasing hormone · Urotensin-II · Vasopressin (1A, 1B, 2)

Miscellaneous

Orphan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other	Adrenomedullin · Olfactory · Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Protease-activated (1, 2, 3, 4) · SREB (1, 2, 3)

Class B: Secretin like

Orphan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other	Brain-specific angiogenesis inhibitor (1, 2, 3) · Cadherin (1, 2, 3) · Calcitonin · CALCRL · CD97 · Corticotropin-releasing hormone (1, 2) · EMR (1, 2, 3) · Glucagon (GR, GIPR, GLP1R, GLP2R) · Growth hormone releasing hormone · PACAPR1 · GPR · Latrophilin (1, 2, 3, ELTD1) · Methuselah-like proteins · Parathyroid hormone (1, 2) · Secretin · Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic
glutamate / pheromone

Taste	TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other	Calcium-sensing receptor · GABA B (1, 2) · Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) · GPRC6A · GPR (156, 158, 179) · RAIG (1, 2, 3, 4)

Class F:
Frizzled / Smoothened

Frizzled	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened	Smoothened

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)