EP1 receptor

EP1 receptor

Prostaglandin E receptor 1 (subtype EP1) is a 42kDa prostaglandin receptor. PTGER1 is its human gene.cite web | title = Entrez Gene: PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5731| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.cite web | title = Entrez Gene: PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5731| accessdate = ]

ee also

* Eicosanoid receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Coleman RA, Smith WL, Narumiya S |title=International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. |journal=Pharmacol. Rev. |volume=46 |issue= 2 |pages= 205–29 |year= 1994 |pmid= 7938166 |doi=
*cite journal | author=Lee TY, Watanabe Y |title=A nonlinear regression model as applied to the comparison of axis-angles of electrocardiographic systems. |journal=Japanese heart journal |volume=16 |issue= 3 |pages= 243–56 |year= 1975 |pmid= 1160156 |doi=
*cite journal | author=Duncan AM, Anderson LL, Funk CD, "et al." |title=Chromosomal localization of the human prostanoid receptor gene family. |journal=Genomics |volume=25 |issue= 3 |pages= 740–2 |year= 1995 |pmid= 7759114 |doi=
*cite journal | author=Funk CD, Furci L, FitzGerald GA, "et al." |title=Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26767–72 |year= 1994 |pmid= 8253813 |doi=
*cite journal | author=Kurihara Y, Endo H, Kondo H |title=Induction of IL-6 via the EP3 subtype of prostaglandin E receptor in rat adjuvant-arthritic synovial cells. |journal=Inflamm. Res. |volume=50 |issue= 1 |pages= 1–5 |year= 2001 |pmid= 11235015 |doi=
*cite journal | author=Kyveris A, Maruscak E, Senchyna M |title=Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR. |journal=Mol. Vis. |volume=8 |issue= |pages= 51–8 |year= 2002 |pmid= 11951086 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Matsuoka Y, Furuyashiki T, Bito H, "et al." |title=Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 7 |pages= 4132–7 |year= 2003 |pmid= 12642666 |doi= 10.1073/pnas.0633341100
*cite journal | author=Richards JA, Brueggemeier RW |title=Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 6 |pages= 2810–6 |year= 2003 |pmid= 12788892 |doi=
*cite journal | author=Kitamura T, Itoh M, Noda T, "et al." |title=Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice. |journal=Cancer Sci. |volume=94 |issue= 7 |pages= 618–21 |year= 2004 |pmid= 12841871 |doi=
*cite journal | author=Moreland RB, Kim N, Nehra A, "et al." |title=Functional prostaglandin E (EP) receptors in human penile corpus cavernosum. |journal=Int. J. Impot. Res. |volume=15 |issue= 5 |pages= 362–8 |year= 2004 |pmid= 14562138 |doi= 10.1038/sj.ijir.3901042
*cite journal | author=Su JL, Shih JY, Yen ML, "et al." |title=Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma. |journal=Cancer Res. |volume=64 |issue= 2 |pages= 554–64 |year= 2004 |pmid= 14744769 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Han C, Wu T |title=Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt. |journal=J. Biol. Chem. |volume=280 |issue= 25 |pages= 24053–63 |year= 2005 |pmid= 15855163 |doi= 10.1074/jbc.M500562200
*cite journal | author=Nicola C, Timoshenko AV, Dixon SJ, "et al." |title=EP1 receptor-mediated migration of the first trimester human extravillous trophoblast: the role of intracellular calcium and calpain. |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 8 |pages= 4736–46 |year= 2005 |pmid= 15886234 |doi= 10.1210/jc.2005-0413
*cite journal | author=Han C, Michalopoulos GK, Wu T |title=Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells. |journal=J. Cell. Physiol. |volume=207 |issue= 1 |pages= 261–70 |year= 2006 |pmid= 16331686 |doi= 10.1002/jcp.20560
*cite journal | author=Durrenberger PF, Facer P, Casula MA, "et al." |title=Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study. |journal=BMC neurology |volume=6 |issue= |pages= 1 |year= 2006 |pmid= 16393343 |doi= 10.1186/1471-2377-6-1
*cite journal | author=McGraw DW, Mihlbachler KA, Schwarb MR, "et al." |title=Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex. |journal=J. Clin. Invest. |volume=116 |issue= 5 |pages= 1400–9 |year= 2006 |pmid= 16670773 |doi= 10.1172/JCI25840
*cite journal | author=Horita H, Kuroda E, Hachisuga T, "et al." |title=Induction of prostaglandin E2 production by leukemia inhibitory factor promotes migration of first trimester extravillous trophoblast cell line, HTR-8/SVneo. |journal=Hum. Reprod. |volume=22 |issue= 7 |pages= 1801–9 |year= 2007 |pmid= 17525067 |doi= 10.1093/humrep/dem125

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • Prostaglandin receptor — There are currently nine known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven transmembrane receptors, G protein coupled receptors.cite journal | author = Tsuboi K, Sugimoto Y, Ichikawa A | …   Wikipedia

  • Eicosanoid receptor — An eicosanoid receptor is an integral membrane protein which detects the presence of eicosanoid signaling molecules. Most, though not all, are G protein coupled receptors (GPCRs). An example of a non GPCR receptor that binds eicosanoids is PPAR γ …   Wikipedia

  • Prostaglandin E receptor 3 — (subtype EP3), also known as PTGER3, is a prostaglandin receptor, but also denotes the human gene encoding it.cite web | title = Entrez Gene: PTGER3 prostaglandin E receptor 3 (subtype EP3)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • Prostaglandin F receptor — (FP) is a receptor for Prostaglandin F2α. It is encoded by the gene PTGFR.cite web | title = Entrez Gene: PTGFR prostaglandin F receptor (FP)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=5737| accessdate …   Wikipedia

  • Eicosanoide — Estructura química del ácido araquidónico, del cual derivan la gran mayoría de los eicosanoides. Los eicosanoides o icosanoides …   Wikipedia Español

  • Dopamine antagonist — Skeletal formula of clozapine, the first atypical antipsychotic, a dopamine antagonist. A dopamine antagonist is a drug which blocks dopamine receptors by receptor antagonism. There are five known types of dopamine receptors in the human body;… …   Wikipedia

  • Dust cell — A dust cell (or alveolar macrophage) is a type of macrophage found in the pulmonary alveolus, near the pneumocytes, but separated from the wall.Activity of the dust cells is relatively high, because they are located at one of the major boundaries …   Wikipedia

  • Alveolar macrophage — Micrograph showing hemosiderin laden alveolar marcophages, as seen in a pulmonary haemorrhage. H E stain. An alveolar macrophage (or dust cell) is a type of macrophage found in the pulmonary alveolus, near the pneumocytes, but separated from the… …   Wikipedia

  • Prostaglandin — A prostaglandin is any member of a group of lipid compounds that are derived enzymatically from fatty acids and have important functions in the animal body. Every prostaglandin contains 20 carbon atoms, including a 5 carbon ring.They are… …   Wikipedia

  • Prostaglandin D2 synthase — 21kDa (brain), also known as PTGDS, is a human gene.cite web | title = Entrez Gene: PTGDS prostaglandin D2 synthase 21kDa (brain)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=5730| accessdate = ] PBB… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”