EP1 receptor

EP1 receptor

Prostaglandin E receptor 1 (subtype EP1) is a 42kDa prostaglandin receptor. PTGER1 is its human gene.cite web | title = Entrez Gene: PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5731| accessdate = ]

PBB_Summary
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summary_text = The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bacterial endotoxin.cite web | title = Entrez Gene: PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5731| accessdate = ]

ee also

* Eicosanoid receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Coleman RA, Smith WL, Narumiya S |title=International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes. |journal=Pharmacol. Rev. |volume=46 |issue= 2 |pages= 205–29 |year= 1994 |pmid= 7938166 |doi=
*cite journal | author=Lee TY, Watanabe Y |title=A nonlinear regression model as applied to the comparison of axis-angles of electrocardiographic systems. |journal=Japanese heart journal |volume=16 |issue= 3 |pages= 243–56 |year= 1975 |pmid= 1160156 |doi=
*cite journal | author=Duncan AM, Anderson LL, Funk CD, "et al." |title=Chromosomal localization of the human prostanoid receptor gene family. |journal=Genomics |volume=25 |issue= 3 |pages= 740–2 |year= 1995 |pmid= 7759114 |doi=
*cite journal | author=Funk CD, Furci L, FitzGerald GA, "et al." |title=Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26767–72 |year= 1994 |pmid= 8253813 |doi=
*cite journal | author=Kurihara Y, Endo H, Kondo H |title=Induction of IL-6 via the EP3 subtype of prostaglandin E receptor in rat adjuvant-arthritic synovial cells. |journal=Inflamm. Res. |volume=50 |issue= 1 |pages= 1–5 |year= 2001 |pmid= 11235015 |doi=
*cite journal | author=Kyveris A, Maruscak E, Senchyna M |title=Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR. |journal=Mol. Vis. |volume=8 |issue= |pages= 51–8 |year= 2002 |pmid= 11951086 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Matsuoka Y, Furuyashiki T, Bito H, "et al." |title=Impaired adrenocorticotropic hormone response to bacterial endotoxin in mice deficient in prostaglandin E receptor EP1 and EP3 subtypes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 7 |pages= 4132–7 |year= 2003 |pmid= 12642666 |doi= 10.1073/pnas.0633341100
*cite journal | author=Richards JA, Brueggemeier RW |title=Prostaglandin E2 regulates aromatase activity and expression in human adipose stromal cells via two distinct receptor subtypes. |journal=J. Clin. Endocrinol. Metab. |volume=88 |issue= 6 |pages= 2810–6 |year= 2003 |pmid= 12788892 |doi=
*cite journal | author=Kitamura T, Itoh M, Noda T, "et al." |title=Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice. |journal=Cancer Sci. |volume=94 |issue= 7 |pages= 618–21 |year= 2004 |pmid= 12841871 |doi=
*cite journal | author=Moreland RB, Kim N, Nehra A, "et al." |title=Functional prostaglandin E (EP) receptors in human penile corpus cavernosum. |journal=Int. J. Impot. Res. |volume=15 |issue= 5 |pages= 362–8 |year= 2004 |pmid= 14562138 |doi= 10.1038/sj.ijir.3901042
*cite journal | author=Su JL, Shih JY, Yen ML, "et al." |title=Cyclooxygenase-2 induces EP1- and HER-2/Neu-dependent vascular endothelial growth factor-C up-regulation: a novel mechanism of lymphangiogenesis in lung adenocarcinoma. |journal=Cancer Res. |volume=64 |issue= 2 |pages= 554–64 |year= 2004 |pmid= 14744769 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Han C, Wu T |title=Cyclooxygenase-2-derived prostaglandin E2 promotes human cholangiocarcinoma cell growth and invasion through EP1 receptor-mediated activation of the epidermal growth factor receptor and Akt. |journal=J. Biol. Chem. |volume=280 |issue= 25 |pages= 24053–63 |year= 2005 |pmid= 15855163 |doi= 10.1074/jbc.M500562200
*cite journal | author=Nicola C, Timoshenko AV, Dixon SJ, "et al." |title=EP1 receptor-mediated migration of the first trimester human extravillous trophoblast: the role of intracellular calcium and calpain. |journal=J. Clin. Endocrinol. Metab. |volume=90 |issue= 8 |pages= 4736–46 |year= 2005 |pmid= 15886234 |doi= 10.1210/jc.2005-0413
*cite journal | author=Han C, Michalopoulos GK, Wu T |title=Prostaglandin E2 receptor EP1 transactivates EGFR/MET receptor tyrosine kinases and enhances invasiveness in human hepatocellular carcinoma cells. |journal=J. Cell. Physiol. |volume=207 |issue= 1 |pages= 261–70 |year= 2006 |pmid= 16331686 |doi= 10.1002/jcp.20560
*cite journal | author=Durrenberger PF, Facer P, Casula MA, "et al." |title=Prostanoid receptor EP1 and Cox-2 in injured human nerves and a rat model of nerve injury: a time-course study. |journal=BMC neurology |volume=6 |issue= |pages= 1 |year= 2006 |pmid= 16393343 |doi= 10.1186/1471-2377-6-1
*cite journal | author=McGraw DW, Mihlbachler KA, Schwarb MR, "et al." |title=Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex. |journal=J. Clin. Invest. |volume=116 |issue= 5 |pages= 1400–9 |year= 2006 |pmid= 16670773 |doi= 10.1172/JCI25840
*cite journal | author=Horita H, Kuroda E, Hachisuga T, "et al." |title=Induction of prostaglandin E2 production by leukemia inhibitory factor promotes migration of first trimester extravillous trophoblast cell line, HTR-8/SVneo. |journal=Hum. Reprod. |volume=22 |issue= 7 |pages= 1801–9 |year= 2007 |pmid= 17525067 |doi= 10.1093/humrep/dem125

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