Prostaglandin F receptor

Prostaglandin F receptor (FP) is a receptor for Prostaglandin F2α. It is encoded by the gene PTGFR.cite web | title = Entrez Gene: PTGFR prostaglandin F receptor (FP)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5737| accessdate = ]

It is a member of the G-protein coupled receptor family.

Two transcript variants encoding different isoforms have been found for this gene.cite web | title = Entrez Gene: PTGFR prostaglandin F receptor (FP)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5737| accessdate = ]

Functions

Main effects of prostaglandin binding to the receptor are:
* uterine contraction
* bronchoconstriction Pharmacology, (Rang, Dale, Ritter & Moore, ISBN 0443071454, 5:th ed., Churchill Livingstone 2003) Page 234 ]

Via activation of this receptor, PGF2-alpha mediates luteolysis, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus and gastrointestinal tract sphincters [http://www.nature.com/gimo/contents/pt1/full/gimo24.html Signal transduction in lower esophageal sphincter circular muscle] Piero Biancani, Ph.D. and Karen M. Harnett, Ph.D.] .

Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor in ovarian luteal cells initiates luteolysis and thus induces parturition. [cite journal |author=Sugimoto Y, Yamasaki A, Segi E, "et al" |title=Failure of parturition in mice lacking the prostaglandin F receptor |journal=Science |volume=277 |issue=5326 |pages=681–3 |year=1997 |pmid=9235889 |doi=]

ee also

* Eicosanoid receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Duncan AM, Anderson LL, Funk CD, "et al." |title=Chromosomal localization of the human prostanoid receptor gene family. |journal=Genomics |volume=25 |issue= 3 |pages= 740–2 |year= 1995 |pmid= 7759114 |doi=
*cite journal | author=Lake S, Gullberg H, Wahlqvist J, "et al." |title=Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha receptor. |journal=FEBS Lett. |volume=355 |issue= 3 |pages= 317–25 |year= 1995 |pmid= 7988697 |doi=
*cite journal | author=Bastien L, Sawyer N, Grygorczyk R, "et al." |title=Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 11873–7 |year= 1994 |pmid= 8163486 |doi=
*cite journal | author=Funk CD, Furci L, FitzGerald GA, "et al." |title=Cloning and expression of a cDNA for the human prostaglandin E receptor EP1 subtype. |journal=J. Biol. Chem. |volume=268 |issue= 35 |pages= 26767–72 |year= 1994 |pmid= 8253813 |doi=
*cite journal | author=Abramovitz M, Boie Y, Nguyen T, "et al." |title=Cloning and expression of a cDNA for the human prostanoid FP receptor. |journal=J. Biol. Chem. |volume=269 |issue= 4 |pages= 2632–6 |year= 1994 |pmid= 8300593 |doi=
*cite journal | author=Sugimoto Y, Yamasaki A, Segi E, "et al." |title=Failure of parturition in mice lacking the prostaglandin F receptor. |journal=Science |volume=277 |issue= 5326 |pages= 681–3 |year= 1997 |pmid= 9235889 |doi=
*cite journal | author=Kunapuli P, Lawson JA, Rokach J, FitzGerald GA |title=Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha. |journal=J. Biol. Chem. |volume=272 |issue= 43 |pages= 27147–54 |year= 1997 |pmid= 9341156 |doi=
*cite journal | author=Betz R, Lagercrantz J, Kedra D, "et al." |title=Genomic structure, 5' flanking sequences, and precise localization in 1P31.1 of the human prostaglandin F receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=254 |issue= 2 |pages= 413–6 |year= 1999 |pmid= 9918852 |doi= 10.1006/bbrc.1998.9827
*cite journal | author=Kyveris A, Maruscak E, Senchyna M |title=Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR. |journal=Mol. Vis. |volume=8 |issue= |pages= 51–8 |year= 2002 |pmid= 11951086 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Neuschäfer-Rube F, Engemaier E, Koch S, "et al." |title=Identification by site-directed mutagenesis of amino acids contributing to ligand-binding specificity or signal transduction properties of the human FP prostanoid receptor. |journal=Biochem. J. |volume=371 |issue= Pt 2 |pages= 443–9 |year= 2003 |pmid= 12519077 |doi= 10.1042/BJ20021429
*cite journal | author=Zaragoza DB, Wilson R, Eyster K, Olson DM |title=Cloning and characterization of the promoter region of the human prostaglandin F2alpha receptor gene. |journal=Biochim. Biophys. Acta |volume=1676 |issue= 2 |pages= 193–202 |year= 2004 |pmid= 14746914 |doi=
*cite journal | author=Sales KJ, Milne SA, Williams AR, "et al." |title=Expression, localization, and signaling of prostaglandin F2 alpha receptor in human endometrial adenocarcinoma: regulation of proliferation by activation of the epidermal growth factor receptor and mitogen-activated protein kinase signaling pathways. |journal=J. Clin. Endocrinol. Metab. |volume=89 |issue= 2 |pages= 986–93 |year= 2004 |pmid= 14764825 |doi=
*cite journal | author=Vielhauer GA, Fujino H, Regan JW |title=Cloning and localization of hFP(S): a six-transmembrane mRNA splice variant of the human FP prostanoid receptor. |journal=Arch. Biochem. Biophys. |volume=421 |issue= 2 |pages= 175–85 |year= 2004 |pmid= 14984197 |doi=
*cite journal | author=Jin P, Fu GK, Wilson AD, "et al." |title=PCR isolation and cloning of novel splice variant mRNAs from known drug target genes. |journal=Genomics |volume=83 |issue= 4 |pages= 566–71 |year= 2004 |pmid= 15028279 |doi= 10.1016/j.ygeno.2003.09.023
*cite journal | author=Sugino N, Karube-Harada A, Taketani T, "et al." |title=Withdrawal of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation. |journal=J. Reprod. Dev. |volume=50 |issue= 2 |pages= 215–25 |year= 2004 |pmid= 15118249 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Scott G, Jacobs S, Leopardi S, "et al." |title=Effects of PGF2alpha on human melanocytes and regulation of the FP receptor by ultraviolet radiation. |journal=Exp. Cell Res. |volume=304 |issue= 2 |pages= 407–16 |year= 2005 |pmid= 15748887 |doi= 10.1016/j.yexcr.2004.11.016
*cite journal | author=Mandal AK, Ray R, Zhang Z, "et al." |title=Uteroglobin inhibits prostaglandin F2alpha receptor-mediated expression of genes critical for the production of pro-inflammatory lipid mediators. |journal=J. Biol. Chem. |volume=280 |issue= 38 |pages= 32897–904 |year= 2005 |pmid= 16061484 |doi= 10.1074/jbc.M502375200
*cite journal | author=Hébert RL, Carmosino M, Saito O, "et al." |title=Characterization of a rabbit kidney prostaglandin F(2{alpha}) receptor exhibiting G(i)-restricted signaling that inhibits water absorption in the collecting duct. |journal=J. Biol. Chem. |volume=280 |issue= 41 |pages= 35028-37 |year= 2005 |pmid= 16096282 |doi= 10.1074/jbc.M505852200

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