EP4 receptor

EP4 receptor

Prostaglandin E receptor 4 (subtype EP4) is a prostaglandin receptor. PTGER4 is its human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses.cite web | title = Entrez Gene: PTGER4 prostaglandin E receptor 4 (subtype EP4)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5734| accessdate = ]

ee also

* Eicosanoid receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Duncan AM, Anderson LL, Funk CD, "et al." |title=Chromosomal localization of the human prostanoid receptor gene family. |journal=Genomics |volume=25 |issue= 3 |pages= 740–2 |year= 1995 |pmid= 7759114 |doi=
*cite journal | author=Regan JW, Bailey TJ, Pepperl DJ, "et al." |title=Cloning of a novel human prostaglandin receptor with characteristics of the pharmacologically defined EP2 subtype. |journal=Mol. Pharmacol. |volume=46 |issue= 2 |pages= 213–20 |year= 1994 |pmid= 8078484 |doi=
*cite journal | author=Bastien L, Sawyer N, Grygorczyk R, "et al." |title=Cloning, functional expression, and characterization of the human prostaglandin E2 receptor EP2 subtype. |journal=J. Biol. Chem. |volume=269 |issue= 16 |pages= 11873–7 |year= 1994 |pmid= 8163486 |doi=
*cite journal | author=An S, Yang J, Xia M, Goetzl EJ |title=Cloning and expression of the EP2 subtype of human receptors for prostaglandin E2. |journal=Biochem. Biophys. Res. Commun. |volume=197 |issue= 1 |pages= 263–70 |year= 1994 |pmid= 8250933 |doi=
*cite journal | author=Foord SM, Marks B, Stolz M, "et al." |title=The structure of the prostaglandin EP4 receptor gene and related pseudogenes. |journal=Genomics |volume=35 |issue= 1 |pages= 182–8 |year= 1996 |pmid= 8661119 |doi= 10.1006/geno.1996.0337
*cite journal | author=Fedyk ER, Phipps RP |title=Prostaglandin E2 receptors of the EP2 and EP4 subtypes regulate activation and differentiation of mouse B lymphocytes to IgE-secreting cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 20 |pages= 10978–83 |year= 1996 |pmid= 8855294 |doi=
*cite journal | author=Mori K, Tanaka I, Kotani M, "et al." |title=Gene expression of the human prostaglandin E receptor EP4 subtype: differential regulation in monocytoid and lymphoid lineage cells by phorbol ester. |journal=J. Mol. Med. |volume=74 |issue= 6 |pages= 333–6 |year= 1996 |pmid= 8862514 |doi=
*cite journal | author=Mukhopadhyay P, Geoghegan TE, Patil RV, "et al." |title=Detection of EP2, EP4, and FP receptors in human ciliary epithelial and ciliary muscle cells. |journal=Biochem. Pharmacol. |volume=53 |issue= 9 |pages= 1249–55 |year= 1997 |pmid= 9214685 |doi=
*cite journal | author=Cosme R, Lublin D, Takafuji V, "et al." |title=Prostanoids in human colonic mucosa: effects of inflammation on PGE(2) receptor expression. |journal=Hum. Immunol. |volume=61 |issue= 7 |pages= 684–96 |year= 2000 |pmid= 10880739 |doi=
*cite journal | author=Desai S, April H, Nwaneshiudu C, Ashby B |title=Comparison of agonist-induced internalization of the human EP2 and EP4 prostaglandin receptors: role of the carboxyl terminus in EP4 receptor sequestration. |journal=Mol. Pharmacol. |volume=58 |issue= 6 |pages= 1279–86 |year= 2001 |pmid= 11093764 |doi=
*cite journal | author=Sales KJ, Katz AA, Davis M, "et al." |title=Cyclooxygenase-2 expression and prostaglandin E(2) synthesis are up-regulated in carcinomas of the cervix: a possible autocrine/paracrine regulation of neoplastic cell function via EP2/EP4 receptors. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 5 |pages= 2243–9 |year= 2001 |pmid= 11344234 |doi=
*cite journal | author=Faour WH, He Y, He QW, "et al." |title=Prostaglandin E(2) regulates the level and stability of cyclooxygenase-2 mRNA through activation of p38 mitogen-activated protein kinase in interleukin-1 beta-treated human synovial fibroblasts. |journal=J. Biol. Chem. |volume=276 |issue= 34 |pages= 31720–31 |year= 2001 |pmid= 11423555 |doi= 10.1074/jbc.M104036200
*cite journal | author=Desai S, Ashby B |title=Agonist-induced internalization and mitogen-activated protein kinase activation of the human prostaglandin EP4 receptor. |journal=FEBS Lett. |volume=501 |issue= 2-3 |pages= 156–60 |year= 2001 |pmid= 11470276 |doi=
*cite journal | author=Slipetz D, Buchanan S, Mackereth C, "et al." |title=Sequestration and phosphorylation of the prostaglandin E2 EP4 receptor: dependence on the C-terminal tail. |journal=Biochem. Pharmacol. |volume=62 |issue= 8 |pages= 997–1012 |year= 2001 |pmid= 11597569 |doi=
*cite journal | author=Fujino H, West KA, Regan JW |title=Phosphorylation of glycogen synthase kinase-3 and stimulation of T-cell factor signaling following activation of EP2 and EP4 prostanoid receptors by prostaglandin E2. |journal=J. Biol. Chem. |volume=277 |issue= 4 |pages= 2614–9 |year= 2002 |pmid= 11706038 |doi= 10.1074/jbc.M109440200
*cite journal | author=Mutoh M, Watanabe K, Kitamura T, "et al." |title=Involvement of prostaglandin E receptor subtype EP(4) in colon carcinogenesis. |journal=Cancer Res. |volume=62 |issue= 1 |pages= 28–32 |year= 2002 |pmid= 11782353 |doi=
*cite journal | author=Kvirkvelia N, Vojnovic I, Warner TD, "et al." |title=Placentally derived prostaglandin E2 acts via the EP4 receptor to inhibit IL-2-dependent proliferation of CTLL-2 T cells. |journal=Clin. Exp. Immunol. |volume=127 |issue= 2 |pages= 263–9 |year= 2002 |pmid= 11876748 |doi=
*cite journal | author=Asano T, Shoda J, Ueda T, "et al." |title=Expressions of cyclooxygenase-2 and prostaglandin E-receptors in carcinoma of the gallbladder: crucial role of arachidonate metabolism in tumor growth and progression. |journal=Clin. Cancer Res. |volume=8 |issue= 4 |pages= 1157–67 |year= 2002 |pmid= 11948128 |doi=
*cite journal | author=Kyveris A, Maruscak E, Senchyna M |title=Optimization of RNA isolation from human ocular tissues and analysis of prostanoid receptor mRNA expression using RT-PCR. |journal=Mol. Vis. |volume=8 |issue= |pages= 51–8 |year= 2002 |pmid= 11951086 |doi=
*cite journal | author=Scandella E, Men Y, Gillessen S, "et al." |title=Prostaglandin E2 is a key factor for CCR7 surface expression and migration of monocyte-derived dendritic cells. |journal=Blood |volume=100 |issue= 4 |pages= 1354–61 |year= 2002 |pmid= 12149218 |doi= 10.1182/blood-2001-11-0017

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