Sulfite reductase (NADPH)

In enzymology, a sulfite reductase (NADPH) (EC number|1.8.1.2) is an enzyme that catalyzes the chemical reaction

:hydrogen sulfide + 3 NADP⁺ + 3 H₂O $ightleftharpoons$ sulfite + 3 NADPH + 3 H⁺

The 3 substrates of this enzyme are hydrogen sulfide, NADP⁺, and H₂O, whereas its 3 products are sulfite, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is hydrogen-sulfide:NADP+ oxidoreductase. Other names in common use include sulfite (reduced nicotinamide adenine dinucleotide phosphate), reductase, NADPH-sulfite reductase, NADPH-dependent sulfite reductase, H2S-NADP oxidoreductase, and sulfite reductase (NADPH2). This enzyme participates in selenoamino acid metabolism and sulfur metabolism. It has 4 cofactors: FAD, Iron, Heme, and FMN.

tructural studies

As of late 2007, 15 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1AOP, PDB link|1DDG, PDB link|1DDI, PDB link|1YKG, PDB link|2AOP, PDB link|2GEP, PDB link|3AOP, PDB link|3GEO, PDB link|4AOP, PDB link|4GEP, PDB link|5AOP, PDB link|5GEP, PDB link|6GEP, PDB link|7GEP, and PDB link|8GEP.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9029-35-0."

Gene Ontology (GO) codes