List of EC numbers (EC 1)

This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.

EC 1.1 Acting on the CH-OH group of donors

EC 1.1.1 With NAD or NADP as acceptor

*: alcohol dehydrogenase
*: alcohol dehydrogenase (NADP+)
*: homoserine dehydrogenase
*: (R,R)-butanediol dehydrogenase
*: acetoin dehydrogenase
*: glycerol dehydrogenase
*: propanediol-phosphate dehydrogenase
*: glycerol-3-phosphate dehydrogenase (NAD+)
*: D-xylulose reductase
*: L-xylulose reductase
*: D-arabinitol 4-dehydrogenase
*: L-arabinitol 4-dehydrogenase
*: L-arabinitol 2-dehydrogenase
*: L-iditol 2-dehydrogenase
*: D-iditol 2-dehydrogenase
*: galactitol 2-dehydrogenase
*: mannitol-1-phosphate 5-dehydrogenase
*: inositol 2-dehydrogenase
*: L-glucuronate reductase
*: glucuronolactone reductase
*: aldehyde reductase
*: UDP-glucose 6-dehydrogenase
*: histidinol dehydrogenase
*: quinate dehydrogenase
*: shikimate dehydrogenase
*: glyoxylate reductase
*: L-lactate dehydrogenase
*: D-lactate dehydrogenase
*: glycerate dehydrogenase
*: 3-hydroxybutyrate dehydrogenase
*: 3-hydroxyisobutyrate dehydrogenase
*: mevaldate reductase
*: mevaldate reductase (NADPH)
*: hydroxymethylglutaryl-CoA reductase (NADPH)
*: 3-hydroxyacyl-CoA dehydrogenase
*: acetoacetyl-CoA reductase
*: malate dehydrogenase
*: malate dehydrogenase (oxaloacetate-decarboxylating)
*: malate dehydrogenase (decarboxylating)
*: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)
*: isocitrate dehydrogenase (NAD+)
*: isocitrate dehydrogenase (NADP+)
*: phosphogluconate 2-dehydrogenase
*: phosphogluconate dehydrogenase (decarboxylating)
*: L-gulonate 3-dehydrogenase
*: L-arabinose 1-dehydrogenase
*: glucose 1-dehydrogenase
*: galactose 1-dehydrogenase
*: glucose-6-phosphate dehydrogenase
*: 3a-hydroxysteroid dehydrogenase (B-specific)
*: 3(or 17)b-hydroxysteroid dehydrogenase
*: 3a-hydroxycholanate dehydrogenase
*: 3a(or 20b)-hydroxysteroid dehydrogenase
*: allyl-alcohol dehydrogenase
*: lactaldehyde reductase (NADPH)
*: ribitol 2-dehydrogenase
*: fructuronate reductase
*: tagaturonate reductase
*: 3-hydroxypropionate dehydrogenase
*: 2-hydroxy-3-oxopropionate reductase
*: 4-hydroxybutyrate dehydrogenase
*: estradiol 17b-dehydrogenase
*: testosterone 17b-dehydrogenase
*: testosterone 17b-dehydrogenase (NADP+)
*: pyridoxine 4-dehydrogenase
*: w-hydroxydecanoate dehydrogenase
*: mannitol 2-dehydrogenase
*: now *EC 1.7.99.5
*: gluconate 5-dehydrogenase
*: deleted, included in *EC 1.2.1.3
*: alcohol dehydrogenase (NAD(P)+)
*: glycerol dehydrogenase (NADP+)
*: octanol dehydrogenase
*: deleted
*: (R)-aminopropanol dehydrogenase
*: (S,S)-butanediol dehydrogenase
*: lactaldehyde reductase
*: methylglyoxal reductase (NADH-dependent)
*: glyoxylate reductase (NADP+)
*: isopropanol dehydrogenase (NADP+)
*: hydroxypyruvate reductase
*: malate dehydrogenase (NADP+)
*: D-malate dehydrogenase (decarboxylating)
*: dimethylmalate dehydrogenase
*: 3-isopropylmalate dehydrogenase
*: ketol-acid reductoisomerase
*: homoisocitrate dehydrogenase
*: hydroxymethylglutaryl-CoA reductase
*: deleted, included in *EC 1.1.1.86
*: aryl-alcohol dehydrogenase
*: aryl-alcohol dehydrogenase (NADP+)
*: oxaloglycolate reductase (decarboxylating)
*: tartrate dehydrogenase
*: glycerol-3-phosphate dehydrogenase (NAD(P)+)
*: phosphoglycerate dehydrogenase
*: diiodophenylpyruvate reductase
*: 3-hydroxybenzyl-alcohol dehydrogenase
*: (R)-2-hydroxy-fatty-acid dehydrogenase
*: (S)-2-hydroxy-fatty-acid dehydrogenase
*: 3-oxoacyl-(acyl-carrier-protein) reductase
*: acylglycerone-phosphate reductase
*: 3-dehydrosphinganine reductase
*: L-threonine 3-dehydrogenase
*: 4-oxoproline reductase
*: retinol dehydrogenase
*: pantoate 4-dehydrogenase
*: pyridoxal 4-dehydrogenase
*: carnitine 3-dehydrogenase
*: now *EC 1.3.1.28
*: indolelactate dehydrogenase
*: 3-(imidazol-5-yl)lactate dehydrogenase
*: indanol dehydrogenase
*: L-xylose 1-dehydrogenase
*: apiose 1-reductase
*: ribose 1-dehydrogenase (NADP+)
*: D-arabinose 1-dehydrogenase
*: D-arabinose 1-dehydrogenase (NAD(P)+)
*: glucose 1-dehydrogenase (NAD+)
*: glucose 1-dehydrogenase (NADP+)
*: galactose 1-dehydrogenase (NADP+)
*: aldose 1-dehydrogenase
*: D-threo-aldose 1-dehydrogenase
*: sorbose 5-dehydrogenase (NADP+)
*: fructose 5-dehydrogenase (NADP+)
*: 2-deoxy-D-gluconate 3-dehydrogenase
*: 2-dehydro-3-deoxy-D-gluconate 6-dehydrogenase
*: 2-dehydro-3-deoxy-D-gluconate 5-dehydrogenase
*: L-idonate 2-dehydrogenase
*: L-threonate 3-dehydrogenase
*: 3-dehydro-L-gulonate 2-dehydrogenase
*: mannuronate reductase
*: GDP-mannose 6-dehydrogenase
*: dTDP-4-dehydrorhamnose reductase
*: dTDP-6-deoxy-L-talose 4-dehydrogenase
*: GDP-6-deoxy-D-talose 4-dehydrogenase
*: UDP-N-acetylglucosamine 6-dehydrogenase
*: ribitol-5-phosphate 2-dehydrogenase
*: mannitol 2-dehydrogenase (NADP+)
*: deleted, included in *EC 1.1.1.21
*: sorbitol-6-phosphate 2-dehydrogenase
*: 15-hydroxyprostaglandin dehydrogenase (NAD+)
*: D-pinitol dehydrogenase
*: sequoyitol dehydrogenase
*: perillyl-alcohol dehydrogenase
*: 3b-hydroxy-D5-steroid dehydrogenase
*: 11b-hydroxysteroid dehydrogenase
*: 16a-hydroxysteroid dehydrogenase
*: estradiol 17a-dehydrogenase
*: 20a-hydroxysteroid dehydrogenase
*: 21-hydroxysteroid dehydrogenase (NAD+)
*: 21-hydroxysteroid dehydrogenase (NADP+)
*: 3a-hydroxy-5b-androstane-17-one 3a-dehydrogenase
*: sepiapterin reductase
*: ureidoglycolate dehydrogenase
*: identical to *EC 1.1.1.87
*: glycerol 2-dehydrogenase (NADP+)
*: 3-hydroxybutyryl-CoA dehydrogenase
*: UDP-N-acetylmuramate dehydrogenase
*: 7a-hydroxysteroid dehydrogenase
*: dihydrobunolol dehydrogenase
*: cholestanetetraol 26-dehydrogenase
*: erythrulose reductase
*: cyclopentanol dehydrogenase
*: hexadecanol dehydrogenase
*: 2-alkyn-1-ol dehydrogenase
*: hydroxycyclohexanecarboxylate dehydrogenase
*: hydroxymalonate dehydrogenase
*: 2-dehydropantolactone reductase (A-specific)
*: 2-dehydropantoate 2-reductase
*: 3b-hydroxy-4a-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)
*: now *EC 1.5.1.20
*: 2-oxoadipate reductase
*: L-rhamnose 1-dehydrogenase
*: cyclohexane-1,2-diol dehydrogenase
*: D-xylose 1-dehydrogenase
*: 12a-hydroxysteroid dehydrogenase
*: glycerol-3-phosphate 1-dehydrogenase (NADP+)
*: 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
*: D-xylose 1-dehydrogenase (NADP+)
*: deleted, included in *EC 1.1.1.131
*: cholest-5-ene-3b,7a-diol 3b-dehydrogenase
*: deleted, included in *EC 1.1.1.198, *EC 1.1.1.227 and *EC 1.1.1.228
*: geraniol dehydrogenase
*: carbonyl reductase (NADPH)
*: L-glycol dehydrogenase
*: dTDP-galactose 6-dehydrogenase
*: GDP-4-dehydro-D-rhamnose reductase
*: prostaglandin-F synthase
*: prostaglandin-E2 9-reductase
*: indole-3-acetaldehyde reductase (NADH)
*: indole-3-acetaldehyde reductase (NADPH)
*: long-chain-alcohol dehydrogenase
*: 5-amino-6-(5-phosphoribosylamino)uracil reductase
*: coniferyl-alcohol dehydrogenase
*: cinnamyl-alcohol dehydrogenase
*: 15-hydroxyprostaglandin-D dehydrogenase (NADP+)
*: 15-hydroxyprostaglandin dehydrogenase (NADP+)
*: (+)-borneol dehydrogenase
*: (S)-usnate reductase
*: aldose-6-phosphate reductase (NADPH)
*: 7b-hydroxysteroid dehydrogenase (NADP+)
*: 1,3-propanediol dehydrogenase
*: uronate dehydrogenase
*: now *EC 1.17.1.4
*: IMP dehydrogenase
*: tropine dehydrogenase
*: (-)-menthol dehydrogenase
*: (+)-neomenthol dehydrogenase
*: 3(or 17)a-hydroxysteroid dehydrogenase
*: 3b(or 20a)-hydroxysteroid dehydrogenase
*: long-chain-3-hydroxyacyl-CoA dehydrogenase
*: 3-oxoacyl-(acyl-carrier-protein) reductase (NADH)
*: 3a-hydroxysteroid dehydrogenase (A-specific)
*: 2-dehydropantolactone reductase (B-specific)
*: gluconate 2-dehydrogenase
*: farnesol dehydrogenase
*: benzyl-2-methyl-hydroxybutyrate dehydrogenase
*: morphine 6-dehydrogenase
*: dihydrokaempferol 4-reductase
*: 6-pyruvoyltetrahydropterin 2'-reductase
*: vomifoliol 4'-dehydrogenase
*: (R)-4-hydroxyphenyllactate dehydrogenase
*: isopiperitenol dehydrogenase
*: mannose-6-phosphate 6-reductase
*: chlordecone reductase
*: 4-hydroxycyclohexanecarboxylate dehydrogenase
*: (-)-borneol dehydrogenase
*: (+)-sabinol dehydrogenase
*: diethyl 2-methyl-3-oxosuccinate reductase
*: 3a-hydroxyglycyrrhetinate dehydrogenase
*: 15-hydroxyprostaglandin-I dehydrogenase (NADP+)
*: 15-hydroxyicosatetraenoate dehydrogenase
*: N-acylmannosamine 1-dehydrogenase
*: flavanone 4-reductase
*: 8-oxocoformycin reductase
*: tropinone reductase
*: hydroxyphenylpyruvate reductase
*: 12b-hydroxysteroid dehydrogenase
*: 3a(17b)-hydroxysteroid dehydrogenase (NAD+)
*: N-acetylhexosamine 1-dehydrogenase
*: 6-endo-hydroxycineole dehydrogenase
*: zeatin reductase — now *EC 1.3.1.69
*: carveol dehydrogenase
*: methanol dehydrogenase
*: cyclohexanol dehydrogenase
*: pterocarpin synthase
*: codeinone reductase (NADPH)
*: salutaridine reductase (NADPH)
*: reinstated as *EC 2.5.1.46
*: D-arabinitol 2-dehydrogenase
*: galactitol-1-phosphate 5-dehydrogenase
*: tetrahydroxynaphthalene reductase
*: now *EC 1.5.1.33
*: (S)-carnitine 3-dehydrogenase
*: mannitol dehydrogenase
*: fluoren-9-ol dehydrogenase
*: 4-(hydroxymethyl)benzenesulfonate dehydrogenase
*: 6-hydroxyhexanoate dehydrogenase
*: 3-hydroxypimeloyl-CoA dehydrogenase
*: sulcatone reductase
*: glycerol-1-phosphate dehydrogenase (NAD(P)+)
*: 4-hydroxythreonine-4-phosphate dehydrogenase
*: 1,5-anhydro-D-fructose reductase
*: L-idonate 5-dehydrogenase
*: 3-methylbutanal reductase
*: dTDP-4-dehydro-6-deoxyglucose reductase
*: 1-deoxy-D-xylulose-5-phosphate reductoisomerase
*: 2-(R)-hydroxypropyl-CoM dehydrogenase
*: 2-(S)-hydroxypropyl-CoM dehydrogenase
*: 3-keto-steroid reductase
*: GDP-L-fucose synthase
*: (R)-2-hydroxyacid dehydrogenase
*: vellosimine dehydrogenase
*: 2,5-didehydrogluconate reductase
*: (+)-trans-carveol dehydrogenase
*: serine 3-dehydrogenase
*: 3b-hydroxy-5b-steroid dehydrogenase
*: 3b-hydroxy-5a-steroid dehydrogenase
*: (R)-3-hydroxyacid ester dehydrogenase
*: (S)-3-hydroxyacid ester dehydrogenase
*: GDP-4-dehydro-6-deoxy-D-mannose reductase
*: quinate/shikimate dehydrogenase
*: methylglyoxal reductase (NADPH-dependent)
*: S-(hydroxymethyl)glutathione dehydrogenase
*: 3"-deamino-3"-oxonicotianamine reductase
*: isocitrate—homoisocitrate dehydrogenase
*: D-arabinitol dehydrogenase (NADP+)

EC 1.1.2 With a cytochrome as acceptor

*: now *EC 1.1.99.5
*: mannitol dehydrogenase (cytochrome)
*: L-lactate dehydrogenase (cytochrome)
*: D-lactate dehydrogenase (cytochrome)
*: D-lactate dehydrogenase (cytochrome c-553)

EC 1.1.3 With oxygen as acceptor

*: deleted, included in *EC 1.1.3.15
*: now *EC 1.13.12.4
*: malate oxidase
*: glucose oxidase
*: hexose oxidase
*: cholesterol oxidase
*: aryl-alcohol oxidase
*: L-gulonolactone oxidase
*: galactose oxidase
*: pyranose oxidase
*: L-sorbose oxidase
*: pyridoxine 4-oxidase
*: alcohol oxidase
*: catechol oxidase (dimerizing)
*: (S)-2-hydroxy-acid oxidase
*: ecdysone oxidase
*: choline oxidase
*: Secondary-alcohol oxidase
*: 4-hydroxymandelate oxidase
*: long-chain-alcohol oxidase
*: glycerol-3-phosphate oxidase
*: now *EC 1.17.3.2
*: thiamin oxidase
*: L-galactonolactone oxidase
*: now included with *EC 1.1.99.18
*: now *EC 1.21.3.2
*: hydroxyphytanate oxidase
*: nucleoside oxidase
*: N-acylhexosamine oxidase
*: polyvinyl-alcohol oxidase
*: deleted
*: now *EC 1.14.21.1
*: now *EC 1.14.21.2
*: now *EC 1.14.21.3
*: now *EC 1.14.21.4
*: now *EC 1.14.21.5
*: D-arabinono-1,4-lactone oxidase
*: vanillyl-alcohol oxidase
*: nucleoside oxidase (H2O2-forming)
*: D-mannitol oxidase
*: xylitol oxidase

EC 1.1.4 With a disulfide as acceptor

*: vitamin-K-epoxide reductase (warfarin-sensitive)
*: vitamin-K-epoxide reductase (warfarin-insensitive)

EC 1.1.5 With a quinone or similar compound as acceptor

*: deleted, see EC 1.1.99.18 cellobiose dehydrogenase (acceptor)
*: quinoprotein glucose dehydrogenase

EC 1.1.99 With other acceptors

*: choline dehydrogenase
*: 2-hydroxyglutarate dehydrogenase
*: gluconate 2-dehydrogenase (acceptor)
*: dehydrogluconate dehydrogenase
*: glycerol-3-phosphate dehydrogenase
*: D-2-hydroxy-acid dehydrogenase
*: lactate—malate transhydrogenase
*: alcohol dehydrogenase (acceptor)
*: pyridoxine 5-dehydrogenase
*: glucose dehydrogenase (acceptor)
*: fructose 5-dehydrogenase
*: sorbose dehydrogenase
*: glucoside 3-dehydrogenase
*: glycolate dehydrogenase
*: now *EC 1.7.99.5
*: malate dehydrogenase (acceptor)
*: now *EC 1.1.5.2
*: cellobiose dehydrogenase (acceptor)
*: uracil dehydrogenase
*: alkan-1-ol dehydrogenase (acceptor)
*: D-sorbitol dehydrogenase (acceptor)
*: glycerol dehydrogenase (acceptor)
*: polyvinyl-alcohol dehydrogenase (acceptor)
*: hydroxyacid-oxoacid transhydrogenase
*: quinate dehydrogenase (pyrroloquinoline-quinone)
*: 3-hydroxycyclohexanone dehydrogenase
*: (R)-pantolactone dehydrogenase (flavin)
*: glucose-fructose oxidoreductase
*: pyranose dehydrogenase (acceptor)
*: 2-oxoacid reductase

EC 1.2 Acting on the aldehyde or oxo group of donors

EC 1.2.1 With NAD or NADP as acceptor

*: deleted, replaced by *EC 1.1.1.284 and *EC 4.4.1.22
*: formate dehydrogenase
*: aldehyde dehydrogenase (NAD+)
*: aldehyde dehydrogenase (NADP+)
*: aldehyde dehydrogenase (NAD(P)+)
*: deleted
*: benzaldehyde dehydrogenase (NADP+)
*: betaine-aldehyde dehydrogenase
*: glyceraldehyde-3-phosphate dehydrogenase (NADP+)
*: acetaldehyde dehydrogenase (acetylating)
*: aspartate-semialdehyde dehydrogenase
*: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating)
*: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating)
*: now *EC 1.1.1.205
*: malonate-semialdehyde dehydrogenase
*: succinate-semialdehyde dehydrogenase (NAD(P)+)
*: glyoxylate dehydrogenase (acylating)
*: malonate-semialdehyde dehydrogenase (acetylating)
*: aminobutyraldehyde dehydrogenase
*: glutarate-semialdehyde dehydrogenase
*: glycolaldehyde dehydrogenase
*: lactaldehyde dehydrogenase
*: 2-oxoaldehyde dehydrogenase (NAD+)
*: succinate-semialdehyde dehydrogenase
*: 2-oxoisovalerate dehydrogenase (acylating)
*: 2,5-dioxovalerate dehydrogenase
*: methylmalonate-semialdehyde dehydrogenase (acylating)
*: benzaldehyde dehydrogenase (NAD+)
*: aryl-aldehyde dehydrogenase
*: aryl-aldehyde dehydrogenase (NADP+)
*: L-aminoadipate-semialdehyde dehydrogenase
*: aminomuconate-semialdehyde dehydrogenase
*: (R)-dehydropantoate dehydrogenase
*: deleted, included in *EC 1.1.1.131
*: now *EC 1.1.1.203
*: retinal dehydrogenase
*: now *EC 1.1.1.204
*: N-acetyl-g-glutamyl-phosphate reductase
*: phenylacetaldehyde dehydrogenase
*: 3a,7a,12a-trihydroxycholestan-26-al 26-oxidoreductase
*: glutamate-5-semialdehyde dehydrogenase
*: hexadecanal dehydrogenase (acylating)
*: formate dehydrogenase (NADP+)
*: cinnamoyl-CoA reductase
*: 4-carboxy-2-hydroxymuconate-6-semialdehyde dehydrogenase
*: formaldehyde dehydrogenase
*: 4-trimethylammoniobutyraldehyde dehydrogenase
*: long-chain-aldehyde dehydrogenase
*: 2-oxoaldehyde dehydrogenase (NADP+)
*: long-chain-fatty-acyl-CoA reductase
*: pyruvate dehydrogenase (NADP+)
*: oxoglutarate dehydrogenase (NADP+)
*: 4-hydroxyphenylacetaldehyde dehydrogenase
*: g-guanidinobutyraldehyde dehydrogenase
*: now *EC 1.1.1.279
*: now *EC 1.1.1.280
*: butanal dehydrogenase
*: phenylglyoxylate dehydrogenase (acylating)
*: glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+)
*: 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase
*: 4-hydroxymuconic-semialdehyde dehydrogenase
*: 4-formylbenzenesulfonate dehydrogenase
*: 6-oxohexanoate dehydrogenase
*: 4-hydroxybenzaldehyde dehydrogenase
*: salicylaldehyde dehydrogenase
*: mycothiol-dependent formaldehyde dehydrogenase
*: vanillin dehydrogenase
*: coniferyl-aldehyde dehydrogenase
*: fluoroacetaldehyde dehydrogenase
*: glutamyl-tRNA reductase

EC 1.2.2 With a cytochrome as acceptor

*: formate dehydrogenase (cytochrome)
*: pyruvate dehydrogenase (cytochrome)
*: formate dehydrogenase (cytochrome-c-553)
*: carbon-monoxide dehydrogenase (cytochrome b-561)

EC 1.2.3 With oxygen as acceptor

*: aldehyde oxidase
*: now *EC 1.1.3.22
*: pyruvate oxidase
*: oxalate oxidase
*: glyoxylate oxidase
*: pyruvate oxidase (CoA-acetylating)
*: indole-3-acetaldehyde oxidase
*: pyridoxal oxidase
*: aryl-aldehyde oxidase
*: deleted
*: retinal oxidase
*: now *EC 1.14.13.82
*: 4-hydroxyphenylpyruvate oxidase

EC 1.2.4 With a disulfide as acceptor

*: pyruvate dehydrogenase (acetyl-transferring)
*: oxoglutarate dehydrogenase (succinyl-transferring)
*: deleted, included in EC 1.2.4.4
*: 3-methyl-2-oxobutanoate dehydrogenase

EC 1.2.7 With an iron-sulfur protein as acceptor

*: pyruvate synthase
*: 2-oxobutyrate synthase
*: 2-oxoglutarate synthase
*: carbon-monoxide dehydrogenase (ferredoxin)
*: aldehyde ferredoxin oxidoreductase
*: glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)
*: 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin)
*: indolepyruvate ferredoxin oxidoreductase
*: deleted, identical to *EC 1.2.7.3

EC 1.2.99 With other acceptors

*: now *EC 1.1.99.19
*: carbon-monoxide dehydrogenase (acceptor)
*: aldehyde dehydrogenase (pyrroloquinoline-quinone)
*: formaldehyde dismutase
*: formylmethanofuran dehydrogenase
*: carboxylate reductase
*: aldehyde dehydrogenase (FAD-independent)

EC 1.3 Acting on the CH-CH group of donors

EC 1.3.1 With NAD or NADP as acceptor

*: dihydrouracil dehydrogenase (NAD+)
*: dihydropyrimidine dehydrogenase (NADP+)
*: cortisone b-reductase
*: cortisone a-reductase
*: cucurbitacin D23-reductase
*: fumarate reductase (NADH)
*: meso-tartrate dehydrogenase
*: acyl-CoA dehydrogenase (NADP+)
*: enoyl-(acyl-carrier-protein) reductase (NADH)
*: enoyl-(acyl-carrier-protein) reductase (NADPH, B-specific)
*: 2-coumarate reductase
*: prephenate dehydrogenase
*: prephenate dehydrogenase (NADP+)
*: orotate reductase (NADH)
*: orotate reductase (NADPH)
*: b-nitroacrylate reductase
*: 3-methyleneoxindole reductase
*: kynurenate-7,8-dihydrodiol dehydrogenase
*: cis-1,2-dihydrobenzene-1,2-diol dehydrogenase
*: trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
*: 7-dehydrocholesterol reductase
*: cholestenone 5a-reductase
*: cholestenone 5b-reductase
*: biliverdin reductase
*: 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase
*: dihydrodipicolinate reductase
*: 2-hexadecenal reductase
*: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase
*: cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
*: progesterone 5a-reductase
*: 2-enoate reductase
*: maleylacetate reductase
*: protochlorophyllide reductase
*: 2,4-dienoyl-CoA reductase (NADPH)
*: phosphatidylcholine desaturase
*: geissoschizine dehydrogenase
*: cis-2-enoyl-CoA reductase (NADPH)
*: trans-2-enoyl-CoA reductase (NADPH)
*: enoyl-(acyl-carrier-protein) reductase (NADPH, A-specific)
*: 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate reductase
*: xanthommatin reductase
*: 12-oxophytodienoate reductase
*: arogenate dehydrogenase
*: trans-2-enoyl-CoA reductase (NAD+)
*: 2'-hydroxyisoflavone reductase
*: biochanin-A reductase
*: a-santonin 1,2-reductase
*: 15-oxoprostaglandin 13-oxidase
*: cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase
*: now *EC 1.1.1.252
*: 2'-hydroxydaidzein reductase
*: 2-methyl-branched-chain-enoyl-CoA reductase
*: (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate dehydrogenase
*: precorrin-6A reductase
*: now *EC 1.3.1.25
*: cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
*: phloroglucinol reductase
*: 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase
*: 1,2-dihydroxy-3-methyl-1,2-dihydrobenzoate dehydrogenase
*: dibenzothiophene dihydrodiol dehydrogenase
*: terephthalate 1,2-cis-dihydrodiol dehydrogenase
*: pimeloyl-CoA dehydrogenase
*: 2,4-dichlorobenzoyl-CoA reductase
*: phthalate 4,5-cis-dihydrodiol dehydrogenase
*: 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase
*: cis-dihydroethylcatechol dehydrogenase
*: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase
*: 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase
*: zeatin reductase
*: D14-sterol reductase
*: D24(241)-sterol reductase
*: D24-sterol reductase
*: 1,2-dihydrovomilenine reductase
*: 2-alkenal reductase
*: divinyl chlorophyllide a 8-vinyl-reductase
*: precorrin-2 dehydrogenase
*: anthocyanidin reductase
*: arogenate dehydrogenase (NADP+)
*: arogenate dehydrogenase (NAD(P)+)

EC 1.3.2 With a cytochrome as acceptor

*: now EC 1.3.99.2
*: now EC 1.3.99.3
*: galactonolactone dehydrogenase

EC 1.3.3 With oxygen as acceptor

*: dihydroorotate oxidase
*: lathosterol oxidase
*: coproporphyrinogen oxidase
*: protoporphyrinogen oxidase
*: bilirubin oxidase
*: acyl-CoA oxidase
*: dihydrouracil oxidase
*: tetrahydroberberine oxidase
*: secologanin synthase
*: tryptophan a,b-oxidase
*: pyrroloquinoline-quinone synthase

EC 1.3.5 With a quinone or related compound as acceptor

*: succinate dehydrogenase (ubiquinone)

EC 1.3.7 With an iron-sulfur protein as acceptor

*: 6-hydroxynicotinate reductase
*:
*:
*:
*:

EC 1.3.99 With other acceptors

*: succinate dehydrogenase
*: butyryl-CoA dehydrogenase
*: acyl-CoA dehydrogenase
*: 3-oxosteroid 1-dehydrogenase
*: 3-oxo-5a-steroid 4-dehydrogenase
*: 3-oxo-5b-steroid 4-dehydrogenase
*: glutaryl-CoA dehydrogenase
*: 2-furoyl-CoA dehydrogenase
*: now *EC 1.21.99.1
*: isovaleryl-CoA dehydrogenase
*: dihydroorotate dehydrogenase
*: 2-methylacyl-CoA dehydrogenase
*: long-chain-acyl-CoA dehydrogenase
*: cyclohexanone dehydrogenase
*: benzoyl-CoA reductase
*: isoquinoline 1-oxidoreductase
*: quinoline 2-oxidoreductase
*: quinaldate 4-oxidoreductase
*: quinoline-4-carboxylate 2-oxidoreductase
*: 4-hydroxybenzoyl-CoA reductase
*: (R)-benzylsuccinyl-CoA dehydrogenase
*: coproporphyrinogen dehydrogenase

EC 1.4 Acting on the CH-NH2 group of donors

EC 1.4.1 With NAD or NADP as acceptor

*: alanine dehydrogenase
*: glutamate dehydrogenase
*: glutamate dehydrogenase (NAD(P)+)
*: glutamate dehydrogenase (NADP+)
*: L-amino-acid dehydrogenase
*: deleted, included in *EC 1.4.4.1
*: serine 2-dehydrogenase
*: valine dehydrogenase (NADP+)
*: leucine dehydrogenase
*: glycine dehydrogenase
*: L-erythro-3,5-diaminohexanoate dehydrogenase
*: 2,4-diaminopentanoate dehydrogenase
*: glutamate synthase (NADPH)
*: glutamate synthase (NADH)
*: lysine dehydrogenase
*: diaminopimelate dehydrogenase
*: N-methylalanine dehydrogenase
*: lysine 6-dehydrogenase
*: tryptophan dehydrogenase
*: phenylalanine dehydrogenase
*: aspartate dehydrogenase

EC 1.4.2 With a cytochrome as acceptor

*: glycine dehydrogenase (cytochrome)

EC 1.4.3 With oxygen as acceptor

*: D-aspartate oxidase
*: L-amino-acid oxidase
*: D-amino-acid oxidase
*: amine oxidase (flavin-containing)
*: pyridoxamine-phosphate oxidase
*: amine oxidase (copper-containing)
*: D-glutamate oxidase
*: ethanolamine oxidase
*: deleted, included in *EC 1.4.3.4
*: putrescine oxidase
*: L-glutamate oxidase
*: cyclohexylamine oxidase
*: protein-lysine 6-oxidase
*: L-lysine oxidase
*: D-glutamate(D-aspartate) oxidase
*: L-aspartate oxidase
*: now *EC 1.3.3.10
*: deleted, not approved
*: glycine oxidase

EC 1.4.4 With a disulfide as acceptor

*: now EC 1.21.4.1
*: glycine dehydrogenase (decarboxylating)

EC 1.4.7 With an iron-sulfur protein as acceptor

*: glutamate synthase (ferredoxin)

EC 1.4.99 With other acceptors

*: D-amino acid dehydrogenase
*: taurine dehydrogenase
*: amine dehydrogenase
*: aralkylamine dehydrogenase
*: glycine dehydrogenase (cyanide-forming)

=EC 1.5 Acting on the CH-NH group of donors=

=EC 1.5.1 With NAD or NADP as acceptor=

*: pyrroline-2-carboxylate reductase
*: pyrroline-5-carboxylate reductase
*: dihydrofolate reductase
*: deleted, included in *EC 1.5.1.3
*: methylenetetrahydrofolate dehydrogenase (NADP+)
*: formyltetrahydrofolate dehydrogenase
*: saccharopine dehydrogenase (NAD+, L-lysine-forming)
*: saccharopine dehydrogenase (NADP+, L-lysine-forming)
*: saccharopine dehydrogenase (NAD+, L-glutamate-forming)
*: saccharopine dehydrogenase (NADP+, L-glutamate-forming)
*: D-octopine dehydrogenase
*: 1-pyrroline-5-carboxylate dehydrogenase
*: now *EC 1.17.1.5
*: deleted, included in *EC 1.5.1.21
*: methylenetetrahydrofolate dehydrogenase (NAD+)
*: D-lysopine dehydrogenase
*: alanopine dehydrogenase
*: ephedrine dehydrogenase
*: D-nopaline dehydrogenase
*: methylenetetrahydrofolate reductase (NAD(P)H)
*: D1-piperideine-2-carboxylate reductase
*: strombine dehydrogenase
*: tauropine dehydrogenase
*: N5-(carboxyethyl)ornithine synthase
*: thiomorpholine-carboxylate dehydrogenase
*: b-alanopine dehydrogenase
*: 1,2-dehydroreticulinium reductase (NADPH)
*: opine dehydrogenase
*: FMN reductase
*: flavin reductase
*: berberine reductase
*: vomilenine reductase
*: pteridine reductase
*: 6,7-dihydropteridine reductase

EC 1.5.3 With oxygen as acceptor

*: sarcosine oxidase
*: N-methyl-L-amino-acid oxidase
*: deleted
*: N6-methyl-lysine oxidase
*: (S)-6-hydroxynicotine oxidase
*: (R)-6-hydroxynicotine oxidase
*: L-pipecolate oxidase
*: deleted, included in *EC 1.3.3.8
*: now *EC 1.21.3.3
*: dimethylglycine oxidase
*: polyamine oxidase
*: dihydrobenzophenanthridine oxidase

EC 1.5.4 With a disulfide as acceptor

*: pyrimidodiazepine synthase

EC 1.5.5 With a quinone or similar compound as acceptor

*: electron-transferring-flavoprotein dehydrogenase

EC 1.5.7 With an iron-sulfur protein as acceptor

*: methylenetetrahydrofolate reductase (ferredoxin)

EC 1.5.8 With a flavin as acceptor

*: dimethylamine dehydrogenase
*: trimethylamine dehydrogenase

EC 1.5.99 With other acceptors

*: sarcosine dehydrogenase
*: dimethylglycine dehydrogenase
*: L-pipecolate dehydrogenase
*: nicotine dehydrogenase
*: methylglutamate dehydrogenase
*: spermidine dehydrogenase
*: now *EC 1.5.8.2
*: proline dehydrogenase
*: methylenetetrahydromethanopterin dehydrogenase
*: now *EC 1.5.8.1
*: 5,10-methylenetetrahydromethanopterin reductase
*: cytokinin dehydrogenase

EC 1.6 Acting on NADH or NADPH

EC 1.6.1 With NAD or NADP as acceptor

*: NAD(P)+ transhydrogenase (B-specific)
*: NAD(P)+ transhydrogenase (AB-specific)

EC 1.6.2 With a heme protein as acceptor

*: now EC 1.6.99.3
*: cytochrome-b5 reductase
*: deleted
*: NADPH—hemoprotein reductase
*: NADPH—cytochrome-c2 reductase
*: leghemoglobin reductase

EC 1.6.3 With oxygen as acceptor

*: NAD(P)H oxidase

EC 1.6.4 With a disulfide as acceptor

*: now EC 1.8.1.6
*: now EC 1.8.1.7
*: now EC 1.8.1.4
*: now EC 1.8.1.8
*: now EC 1.8.1.9
*: now EC 1.8.1.10
*: now EC 1.8.1.11
*: now EC 1.8.1.12
*: now EC 1.8.1.13
*: now EC 1.8.1.14

EC 1.6.5 With a quinone or similar compound as acceptor

*: deleted
*: NAD(P)H dehydrogenase (quinone)
*: NADH dehydrogenase (ubiquinone)
*: monodehydroascorbate reductase (NADH)
*:
*: p-benzoquinone reductase (NADPH)
*: 2-hydroxy-1,4-benzoquinone reductase

EC 1.6.6 With a nitrogenous group as acceptor

*: now *EC 1.7.1.1
*: now *EC 1.7.1.2
*: now *EC 1.7.1.3
*: now *EC 1.7.1.4
*: now *EC 1.7.99.3
*: now *EC 1.7.1.5
*: now *EC 1.7.1.6
*: now *EC 1.7.1.7
*: trimethylamine-N-oxide reductase
*: now *EC 1.7.1.9
*: now *EC 1.7.1.10
*: now *EC 1.7.1.11
*: now *EC 1.7.1.12

EC 1.6.7 With an iron-sulfur protein as acceptor

*: now EC 1.18.1.2
*: now EC 1.18.1.1

EC 1.6.8 With a flavin as acceptor

*: now EC 1.5.1.29
*: now EC 1.5.1.30

EC 1.6.99 With other acceptors

*: NADPH dehydrogenase
*: now *EC 1.6.5.2
*: NADH dehydrogenase
*: now *EC 1.18.1.2
*: NADH dehydrogenase (quinone)
*: NADPH dehydrogenase (quinone)
*: now *EC 1.5.1.34
*: now *EC 1.16.1.3
*: now *EC 1.16.1.4
*: deleted, included in *EC 1.6.99.7
*: now *EC 1.16.1.5
*: now *EC 1.16.1.6
*: now *EC 1.16.1.7

EC 1.7 Acting on other nitrogenous compounds as donors

EC 1.7.1 With NAD+ or NADP+ as acceptor

*: nitrate reductase (NADH)
*: nitrate reductase (NAD(P)H)
*: nitrate reductase (NADPH)
*: nitrite reductase (NAD(P)H)
*: hyponitrite reductase
*: azobenzene reductase
*: GMP reductase
*: deleted entry
*: nitroquinoline-N-oxide reductase
*: hydroxylamine reductase (NADH)
*: 4-(dimethylamino)phenylazoxybenzene reductase
*: N-hydroxy-2-acetamidofluorene reductase

EC 1.7.2 With a cytochrome as acceptor

*: nitrite reductase (NO-forming)
*: nitrite reductase (cytochrome; ammonia-forming)
*: trimethylamine-N-oxide reductase (cytochrome c)

EC 1.7.3 With oxygen as acceptor

*: nitroalkane oxidase
*: acetylindoxyl oxidase
*: urate oxidase
*: hydroxylamine oxidase
*: 3-aci-nitropropanoate oxidase

EC 1.7.7 With an iron-sulfur protein as acceptor

*: ferredoxin—nitrite reductase
*: ferredoxin—nitrate reductase

EC 1.7.99 With other acceptors

*: hydroxylamine reductase
*: deleted
*: included with *EC 1.7.2.1
*: nitrate reductase
*: deleted, now included with *EC 1.5.1.20
*: nitrous-oxide reductase
*: nitric-oxide reductase
*: hydroxylamine oxidoreductase

EC 1.8 Acting on a sulfur group of donors

EC 1.8.1 With NAD or NADP as acceptor

*: deleted
*: sulfite reductase (NADPH)
*: hypotaurine dehydrogenase
*: dihydrolipoyl dehydrogenase
*: 2-oxopropyl-CoM reductase (carboxylating)
*: cystine reductase
*: glutathione-disulfide reductase
*: protein-disulfide reductase
*: thioredoxin-disulfide reductase
*: CoA-glutathione reductase
*: asparagusate reductase
*: trypanothione-disulfide reductase
*: bis-g-glutamylcystine reductase
*: CoA-disulfide reductase
*: mycothione reductase

EC 1.8.2 With a cytochrome as acceptor

*: sulfite dehydrogenase
*: thiosulfate dehydrogenase

EC 1.8.3 With oxygen as acceptor

*: sulfite oxidase
*: thiol oxidase
*: glutathione oxidase
*: methanethiol oxidase
*: prenylcysteine oxidase

EC 1.8.4 With a disulfide as acceptor

*: glutathione—homocystine transhydrogenase
*: protein-disulfide reductase (glutathione)
*: glutathione—CoA-glutathione transhydrogenase
*: glutathione—cystine transhydrogenase
*: methionine-S-oxide reductase
*: protein-methionine-S-oxide reductase
*: enzyme-thiol transhydrogenase (glutathione-disulfide)
*: phosphoadenylyl-sulfate reductase (thioredoxin)
*: adenylyl-sulfate reductase (glutathione)
*: adenylyl-sulfate reductase (thioredoxin)

EC 1.8.5 With a quinone or similar compound as acceptor

*: glutathione dehydrogenase (ascorbate)
*: thiosulfate dehydrogenase (quinone)

EC 1.8.6 With a nitrogenous group as acceptor

*: deleted, included in EC 2.5.1.18

EC 1.8.7 With an iron-sulfur protein as acceptor

*: sulfite reductase (ferredoxin)

EC 1.8.98 With other, known, acceptors

*: CoB—CoM heterodisulfide reductase
*: sulfiredoxin

EC 1.8.99 With other acceptors

*: sulfite reductase
*: adenylyl-sulfate reductase
*: hydrogensulfite reductase
*: now EC 1.8.4.8

EC 1.9 Acting on a heme group of donors

EC 1.9.3 With oxygen as acceptor

*: cytochrome-c oxidase
*: included with EC 1.7.2.1

EC 1.9.6 With a nitrogenous group as acceptor

*: nitrate reductase (cytochrome)

EC 1.9.99 With other acceptors

*: iron—cytochrome-c reductase

EC 1.10 Acting on diphenols and related substances as donors

EC 1.10.1 With NAD or NADP as acceptor

*: trans-acenaphthene-1,2-diol dehydrogenase

EC 1.10.2 With a cytochrome as acceptor

*: L-ascorbate—cytochrome-b5 reductase
*: ubiquinol—cytochrome-c reductase

EC 1.10.3 With oxygen as acceptor

*: catechol oxidase
*: laccase
*: L-ascorbate oxidase
*: o-aminophenol oxidase
*: 3-hydroxyanthranilate oxidase
*: rifamycin-B oxidase
*: now *EC 1.21.3.4
*: now *EC 1.21.3.5

EC 1.10.99 With other acceptors

*: plastoquinol—plastocyanin reductase
*: ribosyldihydronicotinamide dehydrogenase (quinone)
*: violaxanthin de-epoxidase

EC 1.11 Acting on a peroxide as acceptor

EC 1.11.1 Peroxidases

*: NADH peroxidase
*: NADPH peroxidase
*: fatty-acid peroxidase
*: now *EC 1.13.11.11
*: cytochrome-c peroxidase
*: catalase
*: peroxidase
*: iodide peroxidase
*: glutathione peroxidase
*: chloride peroxidase
*: L-ascorbate peroxidase
*: phospholipid-hydroperoxide glutathione peroxidase
*: manganese peroxidase
*: diarylpropane peroxidase
*: peroxiredoxin

EC 1.12 Acting on hydrogen as donor

EC 1.12.1 With NAD or NADP as acceptor

*: now EC 1.18.99.1
*: hydrogen dehydrogenase
*: hydrogen dehydrogenase (NADP+)

EC 1.12.2 With a cytochrome as acceptor

*: cytochrome-c3 hydrogenase

EC 1.12.5 With a quinone or similar compound as acceptor

*:

EC 1.12.7 With an iron-sulfur protein as acceptor

*: now EC 1.18.99.1
*: ferredoxin hydrogenase

EC 1.12.98 With other known acceptors

*: coenzyme F420 hydrogenase
*: 5,10-methenyltetrahydromethanopterin hydrogenase
*: Methanosarcina-phenazine hydrogenase

EC 1.12.99 With other acceptors

*: now *EC 1.12.98.1
*: deleted, composed of *EC 1.12.98.3 and *EC 1.8.98.1
*: now *EC 1.12.5.1
*: now *EC 1.12.98.2
*: identical to *EC 1.13.11.47
*: hydrogenase (acceptor)

EC 1.13 Acting on single donors with incorporation of molecular oxygen (oxygenases)

EC 1.13.1 (transferred to EC 1.13.11)

*: now *EC 1.13.11.1
*: now *EC 1.13.11.2
*: now *EC 1.13.11.3
*: now *EC 1.13.11.4
*: now *EC 1.13.11.5
*: now *EC 1.13.11.6
*: now *EC 1.13.11.7
*: now *EC 1.13.11.8
*: now *EC 1.13.11.9
*: now *EC 1.13.11.10
*: now *EC 1.13.99.1
*: now *EC 1.13.11.11
*: now *EC 1.13.11.12

EC 1.13.11 With incorporation of two atoms of oxygen

*: catechol 1,2-dioxygenase
*: catechol 2,3-dioxygenase
*: protocatechuate 3,4-dioxygenase
*: gentisate 1,2-dioxygenase
*: homogentisate 1,2-dioxygenase
*: 3-hydroxyanthranilate 3,4-dioxygenase
*: deleted
*: protocatechuate 4,5-dioxygenase
*: 2,5-dihydroxypyridine 5,6-dioxygenase
*: 7,8-dihydroxykynurenate 8,8a-dioxygenase
*: tryptophan 2,3-dioxygenase
*: lipoxygenase
*: ascorbate 2,3-dioxygenase
*: 2,3-dihydroxybenzoate 3,4-dioxygenase
*: 3,4-dihydroxyphenylacetate 2,3-dioxygenase
*: 3-carboxyethylcatechol 2,3-dioxygenase
*: indole 2,3-dioxygenase
*: sulfur dioxygenase
*: cysteamine dioxygenase
*: cysteine dioxygenase
*: now *EC 1.14.99.36
*: caffeate 3,4-dioxygenase
*: 2,3-dihydroxyindole 2,3-dioxygenase
*: quercetin 2,3-dioxygenase
*: 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
*: peptide-tryptophan 2,3-dioxygenase
*: 4-hydroxyphenylpyruvate dioxygenase
*: 2,3-dihydroxybenzoate 2,3-dioxygenase
*: stizolobate synthase
*: stizolobinate synthase
*: arachidonate 12-lipoxygenase
*: 2-nitropropane dioxygenase
*: arachidonate 15-lipoxygenase
*: arachidonate 5-lipoxygenase
*: pyrogallol 1,2-oxygenase
*: chloridazon-catechol dioxygenase
*: hydroxyquinol 1,2-dioxygenase
*: 1-hydroxy-2-naphthoate 1,2-dioxygenase
*: biphenyl-2,3-diol 1,2-dioxygenase
*: arachidonate 8-lipoxygenase
*: 2,4'-dihydroxyacetophenone dioxygenase
*: indoleamine-pyrrole 2,3-dioxygenase
*: lignostilbene ab-dioxygenase
*: linoleate diol synthase
*: linoleate 11-lipoxygenase
*: 4-hydroxymandelate synthase
*: 3-hydroxy-4-oxoquinoline 2,4-dioxygenase
*: 3-hydroxy-2-methyl-quinolin-4-one 2,4-dioxygenase
*: chlorite O2-lyase
*: acetylacetone-cleaving enzyme

EC 1.13.12 With incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

*: arginine 2-monooxygenase
*: lysine 2-monooxygenase
*: tryptophan 2-monooxygenase
*: lactate 2-monooxygenase
*: Renilla-luciferin 2-monooxygenase
*: Cypridina-luciferin 2-monooxygenase
*: Photinus-luciferin 4-monooxygenase (ATP-hydrolysing)
*: Watasenia-luciferin 2-monooxygenase
*: phenylalanine 2-monooxygenase
*: covered by *EC 1.14.13.59
*: methylphenyltetrahydropyridine N-monooxygenase
*: apo-b-carotenoid-14',13'-dioxygenase
*: Oplophorus-luciferin 2-monooxygenase

EC 1.13.99 Miscellaneous

*: inositol oxygenase
*: now EC 1.14.12.10
*: tryptophan 2'-dioxygenase
*: now EC 1.14.12.9
*: now EC 1.13.11.47

EC 1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen

EC 1.14.1 With NADH or NADPH as one donor (deleted sub-subclass)

*: now *EC 1.14.14.1
*: now *EC 1.14.13.9
*: deleted, covered by *EC 1.14.99.7, *EC 5.4.99.7
*: now *EC 1.14.99.2
*: now *EC 1.14.13.5
*: now *EC 1.14.15.4
*: now *EC 1.14.99.9
*: now *EC 1.14.99.10
*: deleted
*: now *EC 1.14.99.11
*: deleted

EC 1.14.2 With ascorbate as one donor (deleted sub-subclass)

*: now EC 1.14.17.1
*: now EC 1.13.11.27

EC 1.14.3 With reduced pteridine as one donor (deleted sub-subclass)

*: now EC 1.14.16.1

EC 1.14.11 With 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

*: g-butyrobetaine dioxygenase
*: procollagen-proline dioxygenase
*: pyrimidine-deoxynucleoside 2'-dioxygenase
*: procollagen-lysine 5-dioxygenase
*: deleted, included in *EC 1.14.11.6
*: thymine dioxygenase
*: procollagen-proline 3-dioxygenase
*: trimethyllysine dioxygenase
*: flavanone 3-dioxygenase
*: pyrimidine-deoxynucleoside 1'-dioxygenase
*: hyoscyamine (6S)-dioxygenase
*: gibberellin-44 dioxygenase
*: gibberellin 2b-dioxygenase
*: 6b-hydroxyhyoscyamine epoxidase
*: gibberellin 3b-dioxygenase
*: peptide-aspartate b-dioxygenase
*: taurine dioxygenase
*: phytanoyl-CoA dioxygenase
*: leucocyanidin oxygenase
*: deacetoxyvindoline 4-hydroxylase
*: clavaminate synthase
*: flavone synthase
*: flavonol synthase
*: 2'-deoxymugineic-acid 2'-dioxygenase
*: mugineic-acid 3-dioxygenase

EC 1.14.12 With NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor

*: anthranilate 1,2-dioxygenase (deaminating, decarboxylating)
*: now *EC 1.14.13.35
*: benzene 1,2-dioxygenase
*: 3-hydroxy-2-methylpyridinecarboxylate dioxygenase
*: 5-pyridoxate dioxygenase
*: now *EC 1.14.13.66
*: phthalate 4,5-dioxygenase
*: 4-sulfobenzoate 3,4-dioxygenase
*: 4-chlorophenylacetate 3,4-dioxygenase
*: benzoate 1,2-dioxygenase
*: toluene dioxygenase
*: naphthalene 1,2-dioxygenase
*: 2-chlorobenzoate 1,2-dioxygenase
*: 2-aminobenzenesulfonate 2,3-dioxygenase
*: terephthalate 1,2-dioxygenase
*: 2-hydroxyquinoline 5,6-dioxygenase
*: nitric oxide dioxygenase
*: biphenyl 2,3-dioxygenase
*: 3-phenylpropionate dioxygenase

EC 1.14.13 With NADH or NADPH as one donor, and incorporation of one atom of oxygen

*: salicylate 1-monooxygenase
*: 4-hydroxybenzoate 3-monooxygenase
*: 4-hydroxyphenylacetate 3-monooxygenase
*: melilotate 3-monooxygenase
*: imidazoleacetate 4-monooxygenase
*: orcinol 2-monooxygenase
*: phenol 2-monooxygenase
*: dimethylaniline monooxygenase (N-oxide-forming)
*: kynurenine 3-monooxygenase
*: 2,6-dihydroxypyridine 3-monooxygenase
*: trans-cinnamate 4-monooxygenase
*: benzoate 4-monooxygenase
*: calcidiol 1-monooxygenase
*: trans-cinnamate 2-monooxygenase
*: cholestanetriol 26-monooxygenase
*: cyclopentanone monooxygenase
*: cholesterol 7a-monooxygenase
*: 4-hydroxyphenylacetate 1-monooxygenase
*: taxifolin 8-monooxygenase
*: 2,4-dichlorophenol 6-monooxygenase
*: flavonoid 3'-monooxygenase
*: cyclohexanone monooxygenase
*: 3-hydroxybenzoate 4-monooxygenase
*: 3-hydroxybenzoate 6-monooxygenase
*: methane monooxygenase
*: phosphatidylcholine 12-monooxygenase
*: 4-aminobenzoate 1-monooxygenase
*: 3,9-dihydroxypterocarpan 6a-monooxygenase
*: 4-nitrophenol 2-monooxygenase
*: leukotriene-B4 20-monooxygenase
*: 2-nitrophenol 2-monooxygenase
*: albendazole monooxygenase
*: 4-hydroxybenzoate 3-monooxygenase (NAD(P)H)
*: leukotriene-E4 20-monooxygenase
*: anthranilate 3-monooxygenase (deaminating)
*: 5-O-(4-coumaroyl)-D-quinate 3'-monooxygenase
*: methyltetrahydroprotoberberine 14-monooxygenase
*: anhydrotetracycline monooxygenase
*: nitric-oxide synthase
*: anthraniloyl-CoA monooxygenase
*: tyrosine N-monooxygenase
*: hydroxyphenylacetonitrile 2-monooxygenase
*: questin monooxygenase
*: 2-hydroxybiphenyl 3-monooxygenase
*: now *EC 1.14.18.2
*: (-)-menthol monooxygenase
*: (S)-limonene 3-monooxygenase
*: (S)-limonene 6-monooxygenase
*: (S)-limonene 7-monooxygenase
*: pentachlorophenol monooxygenase
*: 6-oxocineole dehydrogenase
*: isoflavone 3'-hydroxylase
*: 4'-methoxyisoflavone 2'-hydroxylase
*: ketosteroid monooxygenase
*: protopine 6-monooxygenase
*: dihydrosanguinarine 10-monooxygenase
*: dihydrochelirubine 12-monooxygenase
*: benzoyl-CoA 3-monooxygenase
*: L-lysine 6-monooxygenase (NADPH)
*: 27-hydroxycholesterol 7a-monooxygenase
*: 2-hydroxyquinoline 8-monooxygenase
*: 4-hydroxyquinoline 3-monooxygenase
*: 3-hydroxyphenylacetate 6-hydroxylase
*: 4-hydroxybenzoate 1-hydroxylase
*: 2-hydroxyquinoline 8-monooxygenase
*: 2-hydroxycyclohexanone 2-monooxygenase
*: quinine 3-monooxygenase
*: 4-hydroxyphenylacetaldehyde oxime monooxygenase
*: alkene monooxygenase
*: sterol 14-demethylase
*: N-methylcoclaurine 3'-monooxygenase
*: methylsterol monooxygenase
*: tabersonine 16-hydroxylase
*: 7-deoxyloganin 7-hydroxylase
*: vinorine hydroxylase
*: taxane 10b-hydroxylase
*: taxane 13a-hydroxylase
*: ent-kaurene oxidase
*: ent-kaurenoic acid oxidase
*: (R)-limonene 6-monooxygenase
*: magnesium-protoporphyrin IX monomethyl ester (oxidative) cyclase
*: vanillate monooxygenase
*: precorrin-3B synthase
*: 4-hydroxyacetophenone monooxygenase
*: glyceollin synthase
*: 2-hydroxyisoflavanone synthase
*: licodione synthase
*: flavonoid 3',5'-hydroxylase
*: isoflavone 2'-hydroxylase
*: zeaxanthin epoxidase
*: deoxysarpagine hydroxylase
*: phenylacetone monooxygenase

EC 1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

*: unspecific monooxygenase
*: deleted, included in EC 1.14.14.1
*: alkanal monooxygenase (FMN-linked)
*: deleted, identical to EC 1.14.15.7
*: alkanesulfonate monooxygenase

EC 1.14.15 With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

*: camphor 5-monooxygenase
*: camphor 1,2-monooxygenase
*: alkane 1-monooxygenase
*: steroid 11b-monooxygenase
*: corticosterone 18-monooxygenase
*: cholesterol monooxygenase (side-chain-cleaving)
*: choline monooxygenase

EC 1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen

*: phenylalanine 4-monooxygenase
*: tyrosine 3-monooxygenase
*: anthranilate 3-monooxygenase
*: tryptophan 5-monooxygenase
*: glyceryl-ether monooxygenase
*: mandelate 4-monooxygenase

EC 1.14.17 With reduced ascorbate as one donor, and incorporation of one atom of oxygen

*: dopamine b-monooxygenase
*: deleted, included in EC 1.14.18.1
*: peptidylglycine monooxygenase
*: aminocyclopropanecarboxylate oxidase

EC 1.14.18 With another compound as one donor, and incorporation of one atom of oxygen

*: monophenol monooxygenase
*: CMP-N-acetylneuraminate monooxygenase

EC 1.14.19 With oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

*: stearoyl-CoA 9-desaturase
*: acyl-(acyl-carrier-protein) desaturase
*: linoleoyl-CoA desaturase

EC 1.14.20 With 2-oxoglutarate as one donor, and the other dehydrogenated

*: deacetoxycephalosporin-C synthase

EC 1.14.21 With NADH or NADPH as one donor, and the other dehydrogenated

*: (S)-stylopine synthase
*: (S)-cheilanthifoline synthase
*: berbamunine synthase
*: salutaridine synthase
*: (S)-canadine synthase

EC 1.14.99 Miscellaneous

*: prostaglandin-endoperoxide synthase
*: kynurenine 7,8-hydroxylase
*: heme oxygenase (decyclizing)
*: progesterone monooxygenase
*: now *EC 1.14.19.1
*: now *EC 1.14.19.2
*: squalene monooxygenase
*: deleted, included in *EC 1.14.14.1
*: steroid 17a-monooxygenase
*: steroid 21-monooxygenase
*: estradiol 6b-monooxygenase
*: 4-androstene-3,17-dione monooxygenase
*: now *EC 1.14.13.23
*: progesterone 11a-monooxygenase
*: 4-methoxybenzoate monooxygenase (O-demethylating)
*: now *EC 1.14.13.72
*: now *EC 1.14.16.5
*: deleted
*: plasmanylethanolamine desaturase
*: phylloquinone monooxygenase (2,3-epoxidizing)
*: Latia-luciferin monooxygenase (demethylating)
*: ecdysone 20-monooxygenase
*: 3-hydroxybenzoate 2-monooxygenase
*: steroid 9a-monooxygenase
*: now *EC 1.14.19.3
*: 2-hydroxypyridine 5-monooxygenase
*: juglone 3-monooxygenase
*: linalool 8-monooxygenase
*: deoxyhypusine monooxygenase
*: carotene 7,8-desaturase
*: myristoyl-CoA 11-(E) desaturase
*: myristoyl-CoA 11-(Z) desaturase
*: D12-fatty acid dehydrogenase
*: monoprenyl isoflavone epoxidase
*: thiophene-2-carbonyl-CoA monooxygenase
*: b-carotene 15,15'-monooxygenase
*: taxadiene 5a-hydroxylase

EC 1.15 Acting on superoxide as acceptor

EC 1.15.1

*: superoxide dismutase
*: superoxide reductase

EC 1.16 Oxidizing metal ions

EC 1.16.1 With NAD or NADP as acceptor

*: mercury(II) reductase
*: diferric-transferrin reductase
*: aquacobalamin reductase
*: cob(II)alamin reductase
*: aquacobalamin reductase (NADPH)
*: cyanocobalamin reductase (cyanide-eliminating)
*: ferric-chelate reductase
*: (methionine synthase) reductase

EC 1.16.3 With oxygen as acceptor

*: ferroxidase

EC 1.16.8 With flavin as acceptor

*: cob(II)yrinic acid a,c-diamide reductase

EC 1.17 Acting on CH or CH2 groups

EC 1.17.1 With NAD or NADP as acceptor

*: CDP-4-dehydro-6-deoxyglucose reductase
*: 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
*: leucoanthocyanidin reductase
*: xanthine dehydrogenase
*: nicotinate dehydrogenase

EC 1.17.3 With oxygen as acceptor

*: pteridine oxidase
*: xanthine oxidase
*: 6-hydroxynicotinate dehydrogenase

EC 1.17.4 With a disulfide as acceptor

*: ribonucleoside-diphosphate reductase
*: ribonucleoside-triphosphate reductase
*: 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase

EC 1.17.5 With a quinone or similar compound as acceptor

*: phenylacetyl-CoA dehydrogenase

EC 1.17.99 With other acceptors

*: 4-cresol dehydrogenase (hydroxylating)
*: ethylbenzene hydroxylase
*: 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase

EC 1.18 Acting on iron-sulfur proteins as donors

EC 1.18.1 With NAD⁺ or NADP⁺ as acceptor

*: rubredoxin—NAD+ reductase
*: ferredoxin—NADP+ reductase
*: ferredoxin—NAD+ reductase
*: rubredoxin—NAD(P)+ reductase

EC 1.18.2 With dinitrogen as acceptor (transferred to EC 1.18.6)

*: now EC 1.18.6.1

EC 1.18.3 With H⁺ as acceptor

*: now EC 1.18.99.1

EC 1.18.6 With dinitrogen as acceptor

*: nitrogenase

EC 1.18.96 With other, known, acceptors

*: now EC 1.15.1.2

EC 1.18.99 With H⁺ as acceptor

*: now EC 1.12.7.2

EC 1.19 Acting on reduced flavodoxin as donor

EC 1.19.6 With dinitrogen as acceptor

*: nitrogenase (flavodoxin)

EC 1.20 Acting on phosphorus or arsenic in donors

EC 1.20.1 Acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor

*: phosphonate dehydrogenase

EC 1.20.4 Acting on phosphorus or arsenic in donors, with disulfide as acceptor

*: arsenate reductase (glutaredoxin)
*: methylarsonate reductase

EC 1.20.98 Acting on phosphorus or arsenic in donors, with other, known acceptors

*: arsenate reductase (azurin)

EC 1.20.99 Acting on phosphorus or arsenic in donors, with other acceptors

*: arsenate reductase (donor)

EC 1.21 Acting on X-H and Y-H to form an X-Y bond

EC 1.21.3 With oxygen as acceptor

*: isopenicillin-N synthase
*: columbamine oxidase
*: reticuline oxidase
*: sulochrin oxidase ((+)-bisdechlorogeodin-forming)
*: sulochrin oxidase ((-)-bisdechlorogeodin-forming)
*: aureusidin synthase

EC 1.21.4 With a disulfide as acceptor

*: D-proline reductase (dithiol)
*: glycine reductase
*: sarcosine reductase
*: betaine reductase

EC 1.21.99 With other acceptors

*: b-cyclopiazonate dehydrogenase

EC 1.97 Other oxidoreductases

EC 1.97.1

*: chlorate reductase
*: pyrogallol hydroxytransferase
*: sulfur reductase
*: (formate-C-acetyltransferase)-activating enzyme
*: now *EC 1.20.4.1
*: now *EC 1.20.99.1
*: now *EC 1.20.4.2
*: tetrachloroethene reductive dehalogenase
*: selenate reductase
*: thyroxine 5'-deiodinase
*: thyroxine 5-deiodinase

EC 1.98 Enzymes using H2 as reductant

EC 1.98.1

*: now EC 1.18.99.1

EC 1.99 Other enzymes using O2 as oxidant

EC 1.99.1 Hydroxylases (now covered by EC 1.14)

*: deleted, now *EC 1.14.14.1
*: deleted, now *EC 1.14.16.1
*: deleted
*: deleted
*: deleted, now *EC 1.14.13.9
*: deleted
*: deleted, now *EC 1.14.15.4
*: deleted
*: deleted, now *EC 1.14.99.9
*: deleted
*: deleted, now *EC 1.14.99.10
*: deleted
*: deleted, covered by *EC 1.14.99.7 and *EC 5.4.99.7
*: deleted, now *EC 1.13.11.27

EC 1.99.2 Oxygenases (now covered by EC 1.13)

*: deleted, now *EC 1.13.11.12
*: deleted, now *EC 1.13.11.1
*: deleted, now *EC 1.13.11.3
*: deleted, now *EC 1.13.11.4
*: deleted, now *EC 1.13.11.5
*: deleted, now *EC 1.13.99.1