- Nicotinamide adenine dinucleotide phosphate
Nicotinamide adenine dinucleotide phosphate Identifiers CAS number PubChem ChemSpider MeSH ChEBI ChEMBL Jmol-3D images Image 1 Properties Molecular formula C21H29N7O17P3 Molar mass 744.413 (what is: /?)
Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Nicotinamide adenine dinucleotide phosphate, abbreviated NADP+ or TPN in older notation (triphosphopyridine nucleotide), is a coenzyme used in anabolic reactions, such as lipid and nucleic acid synthesis, which require NADPH as a reducing agent.
In chlorophyll, NADP− is added by ferredoxin-NADP+ reductase in the last step of the electron chain of the light reactions of Photosynthesis. The NADPH produced is then used as reducing power for the biosynthetic reactions in the Calvin Cycle of photosynthesis. In its energized state, it is NADPH, now holding an extra electron. It is used primarily to create the proton gradient in chloroplasts during the light-dependent reactions.
The oxidative phase of the pentose phosphate pathway is the major source of NADPH in cells, producing approximately 60% of the NADPH required.
NADPH provides the reducing equivalents for biosynthetic reactions and the oxidation-reduction involved in protecting against the toxicity of ROS (reactive oxygen species), allowing the regeneration of GSH (reduced glutathione). NADPH is also used for anabolic pathways, such as lipid synthesis, cholesterol synthesis, and fatty acid chain elongation.
Ball-and-stick models of NADP+ and NADPH
Enzyme cofactors Active forms Base formsvitamins: see vitamins
cof, enz, met
noco, nuvi, sysi/epon, met
Wikimedia Foundation. 2010.