Eicosanoid receptor

Eicosanoid receptor: An eicosanoid receptor is an integral membrane protein which detects the presence of eicosanoid signaling molecules. Most, though not all, are G protein-coupled receptors (GPCRs). An example of a non-GPCR receptor that binds eicosanoids is PPAR-γ.^[1]

The following is a list of the known human eicosanoid GPCRs grouped according to the type of eicosanoid ligand that each binds:^[2]^[3]

Contents

1 Leukotriene

2 Lipoxin

3 Oxoeicosanoid

4 Prostanoid

5 References

6 External links

Leukotriene

Leukotrienes:

CysLT₁ (Cysteinyl leukotriene receptor 1) - CYSLTR1

CysLT₂ (Cysteinyl leukotriene receptor 2) - CYSLTR2

BLT₁ (Leukotriene B₄ receptor) - LTB4R

BLT₂ (Leukotriene B₄ receptor 2) - LTB4R2

Lipoxin

Lipoxins:

LXA4R (Formyl peptide receptor-like 1) - FPRL1

Oxoeicosanoid

Oxoeicosanoid:^[4]

Oxoeicosanoid (OXE) receptor 1 - OXER1

Prostanoid

Prostanoids:

PGD₂: DP-(PGD₂)

DP₁ (Prostaglandin D2 receptor) - PTGDR

DP₂ (GPR44) - GPR44

PGE₂:

EP₁-(PGE₂) (PTGER1) - PTGER1

EP₂-(PGE₂) (PTGER2) - PTGER2

EP₃-(PGE₂) (PTGER3) - PTGER3

EP₄-(PGE₂) (PTGER4) - PTGER4

PGF_2α: FP-(PGF_2α) (PTGFR) - PTGFR

PGI₂ (prostacyclin): IP-(PGI₂) (PTGIR) - PTGIR

TXA₂ (thromboxane): TP-(TXA₂) (TBXA2R) - TBXA2R

References

^ DuBois RN, Gupta R, Brockman J, Reddy BS, Krakow SL, Lazar MA (1998). "The nuclear eicosanoid receptor, PPAR-γ, is aberrantly expressed in colonic cancers". Carcinogenesis 19 (1): 49–53. doi:10.1093/carcin/19.1.49. PMID 9472692.

^ Coleman RA, Smith WL, Narumiya S (1994). "International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes". Pharmacol. Rev. 46 (2): 205–29. PMID 7938166.

^ Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Nicosia S, Serhan CN, Shimizu T, Yokomizo T (2003). "International Union of Pharmacology XXXVII. Nomenclature for leukotriene and lipoxin receptors". Pharmacol. Rev. 55 (1): 195–227. doi:10.1124/pr.55.1.8. PMID 12615958.

^ Brink C, Dahlén SE, Drazen J, Evans JF, Hay DW, Rovati GE, Serhan CN, Shimizu T, Yokomizo T (2004). "International Union of Pharmacology XLIV. Nomenclature for the oxoeicosanoid receptor". Pharmacol. Rev. 56 (1): 149–57. doi:10.1124/pr.56.1.4. PMID 15001665.

External links

"Leukotriene Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1289.

"Prostanoid Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1297.

MeSH Eicosanoid+receptors

v · d · eCell surface receptor: G protein-coupled receptors

Class A:
Rhodopsin like

Neurotransmitter

Adrenergic

α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3

Purinergic

Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)

Serotonin

(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)

Other

Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)

Metabolites and
signaling molecules

Eicosanoid

CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane

Other

Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate · Lysophosphatidic acid (1, 2, 3, 4, 5, 6) · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate

Peptide

Neuropeptide

B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)

Other

Anaphylatoxin (C3a, C5a) · Angiotensin (1, 2) · Apelin · Bombesin (BRS3, GRPR, NMBR) · Bradykinin (B1, B2) · Chemokine · Cholecystokinin (A, B) · Endothelin (A, B) · Formyl peptide (1, 2, 3) · FSH · Galanin (1, 2, 3) · GHB receptor · Gonadotropin-releasing hormone (1, 2) · Ghrelin · Kisspeptin · Luteinizing hormone/choriogonadotropin · MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortin (1, 2, 3, 4, 5) · MCHR (1, 2) · Motilin · Opioid (Delta, Kappa, Mu, Nociceptin & Zeta, but not Sigma) · Orexin (1, 2) · Oxytocin · Prokineticin (1, 2) · Prolactin-releasing peptide · Relaxin (1, 2, 3, 4) · Somatostatin (1, 2, 3, 4, 5) · Tachykinin (1, 2, 3) · Thyrotropin · Thyrotropin-releasing hormone · Urotensin-II · Vasopressin (1A, 1B, 2)

Miscellaneous

Orphan

GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)

Other

Adrenomedullin · Olfactory · Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Protease-activated (1, 2, 3, 4) · SREB (1, 2, 3)

Class B: Secretin like

Orphan

GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)

Other

Brain-specific angiogenesis inhibitor (1, 2, 3) · Cadherin (1, 2, 3) · Calcitonin · CALCRL · CD97 · Corticotropin-releasing hormone (1, 2) · EMR (1, 2, 3) · Glucagon (GR, GIPR, GLP1R, GLP2R) · Growth hormone releasing hormone · PACAPR1 · GPR · Latrophilin (1, 2, 3, ELTD1) · Methuselah-like proteins · Parathyroid hormone (1, 2) · Secretin · Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic
glutamate / pheromone

Taste

TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)

Other

Calcium-sensing receptor · GABA B (1, 2) · Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) · GPRC6A · GPR (156, 158, 179) · RAIG (1, 2, 3, 4)

Class F:
Frizzled / Smoothened

Frizzled

Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)

Smoothened

Smoothened

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

v · d · eMembrane proteins, receptors: cell surface receptors

G protein-coupled receptor

Class A

Eicosanoid receptor (Prostaglandin receptor) · Protease-activated receptor · Neurotransmitter receptor · Purinergic receptor · Biogenic amine receptor · Olfactory receptor

Class B

Secretin receptor

Class C

Metabotropic glutamate receptor

Class D

Pheromone receptor

Class E

cAMP receptor

Class F

Frizzled/smoothened

Ligand-gated ion channel
Purinergic receptor

Enzyme-linked receptor
Serine/threonine-specific protein kinase · Receptor tyrosine kinase · Guanylate cyclase

Other/ungrouped
Asialoglycoprotein receptor · Tumor necrosis factor receptor · Immunoglobulin superfamily · N-Acetylglucosamine receptor · Neuropilins · Transferrin receptor · EDAR · Lipoprotein receptor-related protein

see also cell surface receptor deficiencies
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

Categories:
G protein coupled receptors
Biochemistry stubs

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Oxoeicosanoid receptor 1 — Oxoeicosanoid (OXE) receptor 1 Identifiers Symbols OXER1; GPCR; GPR170; TG1019 External IDs … Wikipedia
Cell surface receptor — The seven transmembrane α helix structure of a G protein coupled receptor Cell surface receptors (membrane receptors, transmembrane receptors) are specialized integral membrane proteins that take part in communication between the cell and the… … Wikipedia
Olfactory receptor — Olfactory receptors expressed in the cell membranes of olfactory receptor neurons are responsible for the detection of odor molecules. Activated olfactory receptors are the initial player in a signal transduction cascade which ultimately produces … Wikipedia
Neurotransmitter receptor — Figure 1. The seven transmembrane α helix structure of a G protein coupled receptor. A Neurotransmitter receptor is a membrane receptor protein[1] that is activated by a Neurotransmitter … Wikipedia
Cysteinyl leukotriene receptor 1 — Identifiers Symbols CYSLTR1; CYSLT1; CYSLT1R; CYSLTR; HG55; HMTMF81; MGC46139 External IDs … Wikipedia
Cysteinyl leukotriene receptor 2 — Identifiers Symbols CYSLTR2; CYSLT2; CYSLT2R; HG57; HPN321; KPG 011; hGPCR21 External IDs … Wikipedia
Thromboxane receptor — The thromboxane receptor is a protein on the surface of cells in the endothelium of blood vessels and in the placenta which interacts with the eicosanoid lipid thromboxane. It is a G protein coupled receptors coupled to the G protein Gq.cite… … Wikipedia
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Academic Dictionaries and Encyclopedias

Eicosanoid receptor

Contents

Leukotriene

Lipoxin

Oxoeicosanoid

Prostanoid

References

External links

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Eicosanoid receptor

Contents

Leukotriene

Lipoxin

Oxoeicosanoid

Prostanoid

References

External links

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