Brain-specific angiogenesis inhibitor 1

Brain-specific angiogenesis inhibitor 1

Brain-specific angiogenesis inhibitor 1, also known as BAI1, is a human gene.cite web | title = Entrez Gene: BAI1 brain-specific angiogenesis inhibitor 1| url =| accessdate = ]

section_title =
summary_text = Angiogenesis is controlled by a local balance between stimulators and inhibitors of new vessel growth and is suppressed under normal physiologic conditions. Angiogenesis has been shown to be essential for growth and metastasis of solid tumors. In order to obtain blood supply for their growth, tumor cells are potently angiogenic and attract new vessels as results of increased secretion of inducers and decreased production of endogenous negative regulators. BAI1 contains at least one 'functional' p53-binding site within an intron, and its expression has been shown to be induced by wildtype p53. There are two other brain-specific angiogenesis inhibitor genes, designated BAI2 and BAI3 which along with BAI1 have similar tissue specificities and structures, however only BAI1 is transcriptionally regulated by p53. BAI1 is postulated to be a member of the secretin receptor family, an inhibitor of angiogenesis and a growth suppressor of glioblastomascite web | title = Entrez Gene: BAI1 brain-specific angiogenesis inhibitor 1| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Van Meir EG, Polverini PJ, Chazin VR, "et al." |title=Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. |journal=Nat. Genet. |volume=8 |issue= 2 |pages= 171–6 |year= 1995 |pmid= 7531056 |doi= 10.1038/ng1094-171
*cite journal | author=Nishimori H, Shiratsuchi T, Urano T, "et al." |title=A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis. |journal=Oncogene |volume=15 |issue= 18 |pages= 2145–50 |year= 1997 |pmid= 9393972 |doi=
*cite journal | author=Shiratsuchi T, Nishimori H, Ichise H, "et al." |title=Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). |journal=Cytogenet. Cell Genet. |volume=79 |issue= 1-2 |pages= 103–8 |year= 1998 |pmid= 9533023 |doi=
*cite journal | author=Shiratsuchi T, Futamura M, Oda K, "et al." |title=Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1. |journal=Biochem. Biophys. Res. Commun. |volume=247 |issue= 3 |pages= 597–604 |year= 1998 |pmid= 9647739 |doi= 10.1006/bbrc.1998.8603
*cite journal | author=Fukushima Y, Oshika Y, Tsuchida T, "et al." |title=Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer. |journal=Int. J. Oncol. |volume=13 |issue= 5 |pages= 967–70 |year= 1998 |pmid= 9772287 |doi=
*cite journal | author=Shiratsuchi T, Oda K, Nishimori H, "et al." |title=Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1. |journal=Biochem. Biophys. Res. Commun. |volume=251 |issue= 1 |pages= 158–65 |year= 1998 |pmid= 9790924 |doi= 10.1006/bbrc.1998.9408
*cite journal | author=Oda K, Shiratsuchi T, Nishimori H, "et al." |title=Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 1-2 |pages= 75–82 |year= 1999 |pmid= 10343108 |doi=
*cite journal | author=Wu Y, Dowbenko D, Spencer S, "et al." |title=Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase. |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21477–85 |year= 2000 |pmid= 10748157 |doi= 10.1074/jbc.M909741199
*cite journal | author=Koh JT, Lee ZH, Ahn KY, "et al." |title=Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein. |journal=Brain Res. Mol. Brain Res. |volume=87 |issue= 2 |pages= 223–37 |year= 2001 |pmid= 11245925 |doi=
*cite journal | author=Duda DG, Sunamura M, Lozonschi L, "et al." |title=Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis. |journal=Br. J. Cancer |volume=86 |issue= 3 |pages= 490–6 |year= 2002 |pmid= 11875720 |doi= 10.1038/sj.bjc.6600067
*cite journal | author=Lim IA, Hall DD, Hell JW |title=Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 21697–711 |year= 2002 |pmid= 11937501 |doi= 10.1074/jbc.M112339200
*cite journal | author=Mori K, Kanemura Y, Fujikawa H, "et al." |title=Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells. |journal=Neurosci. Res. |volume=43 |issue= 1 |pages= 69–74 |year= 2002 |pmid= 12074842 |doi=
*cite journal | author=Kaur B, Brat DJ, Calkins CC, Van Meir EG |title=Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. |journal=Am. J. Pathol. |volume=162 |issue= 1 |pages= 19–27 |year= 2003 |pmid= 12507886 |doi=
*cite journal | author=Adkins JN, Varnum SM, Auberry KJ, "et al." |title=Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry. |journal=Mol. Cell Proteomics |volume=1 |issue= 12 |pages= 947–55 |year= 2003 |pmid= 12543931 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Koh JT, Kook H, Kee HJ, "et al." |title=Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin. |journal=Exp. Cell Res. |volume=294 |issue= 1 |pages= 172–84 |year= 2004 |pmid= 14980512 |doi= 10.1016/j.yexcr.2003.11.008
*cite journal | author=Bjarnadóttir TK, Fredriksson R, Höglund PJ, "et al." |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23–33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004

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