Secretin receptor family

Secretin receptor family

Symbol = 7tm_2
Name = Secretin family of 7 transmembrane receptors

width =
caption =
Pfam= PF00002
InterPro= IPR000832
SCOP = 1bl1
OPM family = 6
OPM protein = 1fjr
PDB= PDB|1bl1 ; 17-30; PDB|1et2 S 184-46 PDB|1et3 S 184-46

Secretin family of 7 transmembrane receptors is a family of evolutionarily related proteins.cite journal | author = Harmar AJ | title = Family-B G-protein-coupled receptors | journal = Genome Biol. | volume = 2 | issue = 12 | pages = REVIEWS3013 | year = 2001 | pmid = 11790261 | doi = 10.1186/gb-2001-2-12-reviews3013 | issn = ]

This family is known as Family B, the secretin-receptor family or family 2 of the G-protein-coupled receptors.They have been described in many animal species, but not in plants, fungi or prokaryotes. Three distinct sub-families (B1-B3) are recognized. Many secretin receptors are regulated by peptide hormones from the glucagon hormone family.

The secretin-like GPCRs include secretin, calcitonin, parathyroid hormone/parathyroid hormone-related peptides and vasoactive intestinal peptide receptors, all of which activate adenylyl cyclase and the phosphatidyl-inositol-calcium pathway. These receptors have 7 transmembrane helices, like rhodopsin-like GPCRs. However,there is no significant sequence identity between these families: the secretin-like receptors thus bear their own unique '7TM' signature.

Subfamily B1

Subfamily B1 contains classical hormone receptors, such as receptors for secretin and glucagon, that are all involved in cAMP-mediated signalling pathways.

*Pituitary adenylate cyclase-activating polypeptide type 1 receptor InterPro|IPR002285
*Calcitonin receptor InterPro|IPR003287
*Corticotropin-releasing hormone receptor InterPro|IPR003051
*Glucose-dependent insulinotropic polypeptide receptor/Gastric inhibitory polypeptide receptor InterPro|IPR001749
*Glucagon receptor-related InterPro|IPR003290
** GLP1R; GLP2R;
*Growth hormone releasing hormone receptor InterPro|IPR003288
*Parathyroid hormone receptor InterPro|IPR002170
*Secretin receptor InterPro|IPR002144
*Vasoactive intestinal peptide receptor InterPro|IPR001571

Subfamily B2

Subfamily B2 contains receptors with long extracellular N-termini, such as the leukocyte cell-surface antigen CD97; calcium-independent receptors for latrotoxin (such as UniProt|O94910, and brain-specific angiogenesis inhibitor receptors (such as UniProt|O14514) amongst others.

*Brain-specific angiogenesis inhibitor InterPro|IPR008077
** BAI1; BAI2; BAI3
*CD97 antigen InterPro|IPR003056
** CD97
*EMR hormone receptor InterPro|IPR001740
*GPR56 orphan receptor InterPro|IPR003910
** GPR56; GPR64; GPR97; GPR110; GPR111; GPR112; GPR113; GPR114; GPR115; GPR123; GPR125; GPR126; GPR128; GPR133; GPR144; GPR157
*Latrophilin receptor InterPro|IPR003924

Subfamily B3

Subfamily B3 includes Methuselah and other Drosophila proteins. Other than the typical seven-transmembrane region, characteristic structural features include an amino-terminal extracellular domain involved in ligand binding, and an intracellular loop (IC3) required for specific G-protein coupling.

*Diuretic hormone receptor InterPro|IPR002001

Unclassified subfamilies

*Ig-hepta receptor InterPro|IPR008078
** GPR116

Unclassified members

DREG; HCTR-5; HCTR-6; KPG_003; KPG_006; KPG_008; KPG_009; RESDA1


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