CD97

CD97

CD97 molecule, also known as CD97, is a human gene.cite web | title = Entrez Gene: CD97 CD97 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=976| accessdate = ]

PBB_Summary
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summary_text = This gene is a member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) molecules, likely encoded by a gene cluster on the short arm of chromosome 19. The encoded product is a glycoprotein that is present on the surface of most activated leukocytes and spans the membrane seven times, which is a defining feature of G protein-coupled receptors. The protein has an extended extracellular region with several N-terminal epidermal growth factor (EGF)-like domains, which mediate binding to its cellular ligand, decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The presence of structural features characteristic of extracellular matrix proteins and transmembrane proteins suggests that this protein is a receptor involved in both cell adhesion and signaling processes early after leukocyte activation. Alternative splicing has been observed for this gene and three variants have been found.cite web | title = Entrez Gene: CD97 CD97 molecule| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=976| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kwakkenbos MJ, Kop EN, Stacey M, "et al." |title=The EGF-TM7 family: a postgenomic view. |journal=Immunogenetics |volume=55 |issue= 10 |pages= 655–66 |year= 2004 |pmid= 14647991 |doi= 10.1007/s00251-003-0625-2
*cite journal | author=Hamann J, Eichler W, Hamann D, "et al." |title=Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain. |journal=J. Immunol. |volume=155 |issue= 4 |pages= 1942–50 |year= 1995 |pmid= 7636245 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Hamann J, Hartmann E, van Lier RA |title=Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily. |journal=Genomics |volume=32 |issue= 1 |pages= 144–7 |year= 1996 |pmid= 8786105 |doi= 10.1006/geno.1996.0092
*cite journal | author=Gray JX, Haino M, Roth MJ, "et al." |title=CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation. |journal=J. Immunol. |volume=157 |issue= 12 |pages= 5438–47 |year= 1997 |pmid= 8955192 |doi=
*cite journal | author=Hamann J, Vogel B, van Schijndel GM, van Lier RA |title=The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF). |journal=J. Exp. Med. |volume=184 |issue= 3 |pages= 1185–9 |year= 1997 |pmid= 9064337 |doi=
*cite journal | author=Aust G, Eichler W, Laue S, "et al." |title=CD97: a dedifferentiation marker in human thyroid carcinomas. |journal=Cancer Res. |volume=57 |issue= 9 |pages= 1798–806 |year= 1997 |pmid= 9135025 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Ghannadan M, Baghestanian M, Wimazal F, "et al." |title=Phenotypic characterization of human skin mast cells by combined staining with toluidine blue and CD antibodies. |journal=J. Invest. Dermatol. |volume=111 |issue= 4 |pages= 689–95 |year= 1998 |pmid= 9764855 |doi= 10.1046/j.1523-1747.1998.00359.x
*cite journal | author=Qian YM, Haino M, Kelly K, Song WC |title=Structural characterization of mouse CD97 and study of its specific interaction with the murine decay-accelerating factor (DAF, CD55). |journal=Immunology |volume=98 |issue= 2 |pages= 303–11 |year= 1999 |pmid= 10540231 |doi=
*cite journal | author=Eichler W |title=CD97 isoform expression in leukocytes. |journal=J. Leukoc. Biol. |volume=68 |issue= 4 |pages= 561–7 |year= 2000 |pmid= 11037979 |doi=
*cite journal | author=Lin HH, Stacey M, Saxby C, "et al." |title=Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24160–9 |year= 2001 |pmid= 11297558 |doi= 10.1074/jbc.M101770200
*cite journal | author=Jaspars LH, Vos W, Aust G, "et al." |title=Tissue distribution of the human CD97 EGF-TM7 receptor. |journal=Tissue Antigens |volume=57 |issue= 4 |pages= 325–31 |year= 2001 |pmid= 11380941 |doi=
*cite journal | author=Steinert M, Wobus M, Boltze C, "et al." |title=Expression and regulation of CD97 in colorectal carcinoma cell lines and tumor tissues. |journal=Am. J. Pathol. |volume=161 |issue= 5 |pages= 1657–67 |year= 2002 |pmid= 12414513 |doi=
*cite journal | author=Visser L, de Vos AF, Hamann J, "et al." |title=Expression of the EGF-TM7 receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis. |journal=J. Neuroimmunol. |volume=132 |issue= 1-2 |pages= 156–63 |year= 2003 |pmid= 12417446 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Stacey M, Chang GW, Davies JQ, "et al." |title=The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans. |journal=Blood |volume=102 |issue= 8 |pages= 2916–24 |year= 2003 |pmid= 12829604 |doi= 10.1182/blood-2002-11-3540
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399

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