EMR2

Egf-like module containing, mucin-like, hormone receptor-like 2, also known as EMR2, is a human gene. EMR2 has also been designated as CD312 (cluster of differentiation 312).

PBB_Summary
section_title =
summary_text = This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 3 on chromosome 19. This protein does not interact with the ligand decay accelerating factor for complement, unlike the related CD97 antigen, and indicates that these very closely related proteins likely have nonredundant functions. This gene results in multiple transcripts encoding distinct isoforms.cite web | title = Entrez Gene: EMR2 egf-like module containing, mucin-like, hormone receptor-like 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30817| accessdate = ]

ee also

* EGF module-containing mucin-like hormone receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3
*cite journal | author=Lin HH, Stacey M, Hamann J, "et al." |title=Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97. |journal=Genomics |volume=67 |issue= 2 |pages= 188–200 |year= 2000 |pmid= 10903844 |doi= 10.1006/geno.2000.6238
*cite journal | author=Lin HH, Stacey M, Saxby C, "et al." |title=Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 24160–9 |year= 2001 |pmid= 11297558 |doi= 10.1074/jbc.M101770200
*cite journal | author=Kwakkenbos MJ, Chang GW, Lin HH, "et al." |title=The human EGF-TM7 family member EMR2 is a heterodimeric receptor expressed on myeloid cells. |journal=J. Leukoc. Biol. |volume=71 |issue= 5 |pages= 854–62 |year= 2002 |pmid= 11994511 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Stacey M, Chang GW, Davies JQ, "et al." |title=The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans. |journal=Blood |volume=102 |issue= 8 |pages= 2916–24 |year= 2003 |pmid= 12829604 |doi= 10.1182/blood-2002-11-3540
*cite journal | author=Chang GW, Stacey M, Kwakkenbos MJ, "et al." |title=Proteolytic cleavage of the EMR2 receptor requires both the extracellular stalk and the GPS motif. |journal=FEBS Lett. |volume=547 |issue= 1-3 |pages= 145–50 |year= 2003 |pmid= 12860403 |doi=10.1016/S0014-5793(03)00695-1
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399
*cite journal | author=Lin HH, Chang GW, Davies JQ, "et al." |title=Autocatalytic cleavage of the EMR2 receptor occurs at a conserved G protein-coupled receptor proteolytic site motif. |journal=J. Biol. Chem. |volume=279 |issue= 30 |pages= 31823–32 |year= 2004 |pmid= 15150276 |doi= 10.1074/jbc.M402974200
*cite journal | author=Bjarnadóttir TK, Fredriksson R, Höglund PJ, "et al." |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23–33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004
*cite journal | author=Chang GW, Davies JQ, Stacey M, "et al." |title=CD312, the human adhesion-GPCR EMR2, is differentially expressed during differentiation, maturation, and activation of myeloid cells. |journal=Biochem. Biophys. Res. Commun. |volume=353 |issue= 1 |pages= 133–8 |year= 2007 |pmid= 17174274 |doi= 10.1016/j.bbrc.2006.11.148

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