Parathyroid hormone receptor

Parathyroid hormone receptor

protein
Name = parathyroid hormone receptor 1
caption =


width =
HGNCid = 9608
Symbol = PTHR1
AltSymbols = PTHR
EntrezGene = 5745
OMIM = 168468
RefSeq = NM_000316
UniProt = Q03431
PDB =
ECnumber =
Chromosome = 3
Arm = p
Band = 22
LocusSupplementaryData = -p21.1
protein
Name = parathyroid hormone receptor 2
caption =


width =
HGNCid = 9609
Symbol = PTHR2
AltSymbols =
EntrezGene = 5746
OMIM = 601469
RefSeq = NM_005048
UniProt = P49190
PDB =
ECnumber =
Chromosome = 2
Arm = q
Band = 33
LocusSupplementaryData =
There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors are members of the 7 transmembrane G protein-coupled family of receptors.cite journal | author = Jüppner H | title = Molecular cloning and characterization of a parathyroid hormone/parathyroid hormone-related peptide receptor: a member of an ancient family of G protein-coupled receptors | journal = Curr. Opin. Nephrol. Hypertens. | volume = 3 | issue = 4 | pages = 371–8 | year = 1994 | pmid = 8076140 | doi = | issn = ]

* parathyroid hormone receptor 1 (PTH1R) is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.cite journal | author = Mannstadt M, Jüppner H, Gardella TJ | title = Receptors for PTH and PTHrP: their biological importance and functional properties | journal = Am. J. Physiol. | volume = 277 | issue = 5 Pt 2 | pages = F665–75 | year = 1999 | pmid = 10564229 | doi = | issn = | url = http://ajprenal.physiology.org/cgi/content/abstract/277/5/F665 ] cite journal | author = Offermanns S, Iida-Klein A, Segre GV, Simon MI | title = G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells | journal = Mol. Endocrinol. | volume = 10 | issue = 5 | pages = 566–74 | year = 1996 | pmid = 8732687 | doi = 10.1210/me.10.5.566 | issn = ]

* parathyroid hormone receptor 2 (PTH2R) is expressed primarily in the central nervous system, pancreas, testis, and placenta.cite journal | author = Usdin TB, Bonner TI, Hoare SR | title = The parathyroid hormone 2 (PTH2) receptor | journal = Recept. Channels | volume = 8 | issue = 3-4 | pages = 211–8 | year = 2002 | pmid = 12529938 | doi = | issn = ]

References

External links

*

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1327 IUPHAR GPCR Database - Parathyroid Hormone Receptors]


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  • Parathyroid hormone receptor 2 — Parathyroid hormone receptor 2, also known as PTHR2, is a human gene.cite web | title = Entrez Gene: PTHR2 parathyroid hormone receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=5746| accessdate = ] …   Wikipedia

  • Parathyroid hormone — (PTH), or parathormone, is secreted by the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calcium (Ca2+) in the blood, whereas calcitonin (a hormone produced by the parafollicular cells (C… …   Wikipedia

  • Parathyroid hormone-related protein — (or PTHrP) is a protein member of the parathyroid hormone family. It is occasionally secreted by cancer cells (breast cancer, certain types of lung cancer including squamous cell carcinoma). However, it also has normal functions.FunctionsPTHrP… …   Wikipedia

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