Parathyroid hormone receptor 1 is a parathyroid hormone receptor It is encoded by the gene "PTHR1". It is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH).
Function
It is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.[cite journal | author = Mannstadt M, Jüppner H, Gardella TJ | title = Receptors for PTH and PTHrP: their biological importance and functional properties | journal = Am. J. Physiol. | volume = 277 | issue = 5 Pt 2 | pages = F665–75 | year = 1999 | pmid = 10564229 | doi = | issn = | url = http://ajprenal.physiology.org/cgi/content/abstract/277/5/F665 ] ][cite journal | author = Offermanns S, Iida-Klein A, Segre GV, Simon MI | title = G alpha q family members couple parathyroid hormone (PTH)/PTH-related peptide and calcitonin receptors to phospholipase C in COS-7 cells | journal = Mol. Endocrinol. | volume = 10 | issue = 5 | pages = 566–74 | year = 1996 | pmid = 8732687 | doi = 10.1210/me.10.5.566 | issn = ] ]Mechanism
It is a member of the secretin family of G protein-coupled receptors. The activity of this receptor is mediated by Gs G proteins which activate adenylyl cyclase. Besides, they also activate phosphatidylinositol-calcium second messenger system.
Pathology
Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis.[cite web | title = Entrez Gene: PTHR1 parathyroid hormone receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5745| accessdate = ] ]ee also
* Parathyroid hormone receptor
References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Bonaventure J, Silve C |title= [Hereditary skeletal dysplasias and FGFR3 and PTHR1 signaling pathways] |journal=Med Sci (Paris) |volume=21 |issue= 11 |pages= 954–61 |year= 2006 |pmid= 16274647 |doi=
*cite journal | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317–20 |year= 1992 |pmid= 1602151 |doi=
*cite journal | author=Schipani E, Kruse K, Jüppner H |title=A constitutively active mutant PTH-PTHrP receptor in Jansen-type metaphyseal chondrodysplasia. |journal=Science |volume=268 |issue= 5207 |pages= 98–100 |year= 1995 |pmid= 7701349 |doi=
*cite journal | author=Schipani E, Weinstein LS, Bergwitz C, "et al." |title=Pseudohypoparathyroidism type Ib is not caused by mutations in the coding exons of the human parathyroid hormone (PTH)/PTH-related peptide receptor gene. |journal=J. Clin. Endocrinol. Metab. |volume=80 |issue= 5 |pages= 1611–21 |year= 1995 |pmid= 7745008 |doi=
*cite journal | author=Pausova Z, Bourdon J, Clayton D, "et al." |title=Cloning of a parathyroid hormone/parathyroid hormone-related peptide receptor (PTHR) cDNA from a rat osteosarcoma (UMR 106) cell line: chromosomal assignment of the gene in the human, mouse, and rat genomes. |journal=Genomics |volume=20 |issue= 1 |pages= 20–6 |year= 1994 |pmid= 8020952 |doi=
*cite journal | author=McCuaig KA, Clarke JC, White JH |title=Molecular cloning of the gene encoding the mouse parathyroid hormone/parathyroid hormone-related peptide receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 11 |pages= 5051–5 |year= 1994 |pmid= 8197183 |doi=
*cite journal | author=Schipani E, Karga H, Karaplis AC, "et al." |title=Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor. |journal=Endocrinology |volume=132 |issue= 5 |pages= 2157–65 |year= 1993 |pmid= 8386612 |doi=
*cite journal | author=Schneider H, Feyen JH, Seuwen K, Movva NR |title=Cloning and functional expression of a human parathyroid hormone receptor. |journal=Eur. J. Pharmacol. |volume=246 |issue= 2 |pages= 149–55 |year= 1993 |pmid= 8397094 |doi=
*cite journal | author=Schipani E, Langman CB, Parfitt AM, "et al." |title=Constitutively activated receptors for parathyroid hormone and parathyroid hormone-related peptide in Jansen's metaphyseal chondrodysplasia. |journal=N. Engl. J. Med. |volume=335 |issue= 10 |pages= 708–14 |year= 1996 |pmid= 8703170 |doi=
*cite journal | author=Zhou AT, Bessalle R, Bisello A, "et al." |title=Direct mapping of an agonist-binding domain within the parathyroid hormone/parathyroid hormone-related protein receptor by photoaffinity crosslinking. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 8 |pages= 3644–9 |year= 1997 |pmid= 9108031 |doi=
*cite journal | author=Schipani E, Jensen GS, Pincus J, "et al." |title=Constitutive activation of the cyclic adenosine 3',5'-monophosphate signaling pathway by parathyroid hormone (PTH)/PTH-related peptide receptors mutated at the two loci for Jansen's metaphyseal chondrodysplasia. |journal=Mol. Endocrinol. |volume=11 |issue= 7 |pages= 851–8 |year= 1997 |pmid= 9178745 |doi=
*cite journal | author=Jobert AS, Zhang P, Couvineau A, "et al." |title=Absence of functional receptors for parathyroid hormone and parathyroid hormone-related peptide in Blomstrand chondrodysplasia. |journal=J. Clin. Invest. |volume=102 |issue= 1 |pages= 34–40 |year= 1998 |pmid= 9649554 |doi=
*cite journal | author=Pellegrini M, Bisello A, Rosenblatt M, "et al." |title=Binding domain of human parathyroid hormone receptor: from conformation to function. |journal=Biochemistry |volume=37 |issue= 37 |pages= 12737–43 |year= 1998 |pmid= 9737850 |doi= 10.1021/bi981265h
*cite journal | author=Zhang P, Jobert AS, Couvineau A, Silve C |title=A homozygous inactivating mutation in the parathyroid hormone/parathyroid hormone-related peptide receptor causing Blomstrand chondrodysplasia. |journal=J. Clin. Endocrinol. Metab. |volume=83 |issue= 9 |pages= 3365–8 |year= 1998 |pmid= 9745456 |doi=
*cite journal | author=Adams AE, Bisello A, Chorev M, "et al." |title=Arginine 186 in the extracellular N-terminal region of the human parathyroid hormone 1 receptor is essential for contact with position 13 of the hormone. |journal=Mol. Endocrinol. |volume=12 |issue= 11 |pages= 1673–83 |year= 1999 |pmid= 9817594 |doi=
*cite journal | author=Matsuzaki K, Katayama K, Takahashi Y, "et al." |title=Human osteoclast-like cells are formed from peripheral blood mononuclear cells in a coculture with SaOS-2 cells transfected with the parathyroid hormone (PTH)/PTH-related protein receptor gene. |journal=Endocrinology |volume=140 |issue= 2 |pages= 925–32 |year= 1999 |pmid= 9927325 |doi=
*cite journal | author=Schipani E, Langman C, Hunzelman J, "et al." |title=A novel parathyroid hormone (PTH)/PTH-related peptide receptor mutation in Jansen's metaphyseal chondrodysplasia. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 9 |pages= 3052–7 |year= 1999 |pmid= 10487664 |doi=
*cite journal | author=Karperien M, van der Harten HJ, van Schooten R, "et al." |title=A frame-shift mutation in the type I parathyroid hormone (PTH)/PTH-related peptide receptor causing Blomstrand lethal osteochondrodysplasia. |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 10 |pages= 3713–20 |year= 1999 |pmid= 10523019 |doi=
*cite journal | author=Watson PH, Fraher LJ, Natale BV, "et al." |title=Nuclear localization of the type 1 parathyroid hormone/parathyroid hormone-related peptide receptor in MC3T3-E1 cells: association with serum-induced cell proliferation. |journal=Bone |volume=26 |issue= 3 |pages= 221–5 |year= 2000 |pmid= 10709993 |doi=
*cite journal | author=Truneh A, Sharma S, Silverman C, "et al." |title=Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor. |journal=J. Biol. Chem. |volume=275 |issue= 30 |pages= 23319–25 |year= 2000 |pmid= 10770955 |doi= 10.1074/jbc.M910438199
External links
* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1327 IUPHAR GPCR Database - Parathyroid Hormone Receptors]
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