Melanin-concentrating hormone receptor

Melanin-concentrating hormone receptor: melanin-concentrating hormone receptor 1

Identifiers

Symbol MCHR1

Alt. symbols GPR24

Entrez 2847

HUGO 4479

OMIM 601751

RefSeq NM_005297

UniProt Q99705

Other data

Locus Chr. 22 q13.3

melanin-concentrating hormone receptor 2

Identifiers

Symbol MCHR2

Alt. symbols GPR145

Entrez 84539

HUGO 20867

OMIM 606111

RefSeq NM_032503

UniProt Q969V1

Other data

Locus Chr. 6 q16

Two Melanin-concentrating hormone receptors (MCHR) have recently been characterized: MCH-R1 and MCH-R2. These two receptors share approximately 38% homology.

MCH-R1 is expressed in all mammals.

MCH-R2 is only found in some primates and carnivores including dogs, ferrets and man.

Contents

1 Clinical significance

2 References

3 See also

4 External links

Clinical significance

Antagonists might be useful in the treatment of obesity^[1]^[2] and anxiety and depression.^[3] An agonist might have possible utility as a treatment for osteoporosis.^[4]

Research is ongoing for antagonists affecting MCH receptors R1 and R2.^[5]^[6]

References

^ Handlon AL, Zhou H (2006). "Melanin-concentrating hormone-1 receptor antagonists for the treatment of obesity". J. Med. Chem. 49 (14): 4017–22. doi:10.1021/jm058239j. PMID 16821761.

^ Luthin DR (2007). "Anti-obesity effects of small molecule melanin-concentrating hormone receptor 1 (MCHR1) antagonists". Life Sci. 81 (6): 423–40. doi:10.1016/j.lfs.2007.05.029. PMID 17655875.

^ Shimazaki T, Yoshimizu T, Chaki S (2006). "Melanin-concentrating hormone MCH1 receptor antagonists: a potential new approach to the treatment of depression and anxiety disorders". CNS drugs 20 (10): 801–11. PMID 16999451.

^ Bohlooly-Y M, Mahlapuu M, Andersén H, Astrand A, Hjorth S, Svensson L, Törnell J, Snaith MR, Morgan DG, Ohlsson C (2004). "Osteoporosis in MCHR1-deficient mice". Biochem. Biophys. Res. Commun. 318 (4): 964–9. doi:10.1016/j.bbrc.2004.04.122. PMID 15147966.

^ Saito Y, Maruyama K (2006). "Identification of melanin-concentrating hormone receptor and its impact on drug discovery". J. Exp. Zoolog. Part a Comp. Exp. Biol. 305 (9): 761–8. doi:10.1002/jez.a.311. PMID 16902961.

^ McBriar MD (2006). "Recent advances in the discovery of melanin-concentrating hormone receptor antagonists". Current opinion in drug discovery & development 9 (4): 496–508. PMID 16889232.

See also

Melanin concentrating hormone

Melanin

External links

"Melanin-Concentrating Hormone Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1339.

MeSH melanin-concentrating+hormone+receptor

MeSH MCHR1+protein,+human

MeSH MCHR2+protein,+human

v · d · eCell surface receptor: G protein-coupled receptors

Class A:
Rhodopsin like

Neurotransmitter

Adrenergic

α1 (A, B, D) · α2 (A, B, C) · β1 · β2 · β3

Purinergic

Adenosine (A1, A2A, A2B, A3) · P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)

Serotonin

(all but 5-HT3) 5-HT1 (A, B, D, E, F) · 5-HT2 (A, B, C) · 5-HT (4, 5A, 6, 7)

Other

Acetylcholine (M1, M2, M3, M4, M5) · Dopamine (D1, D2, D3, D4, D5) · Histamine (H1, H2, H3, H4) · Melatonin (1A, 1B, 1C) · TAAR (1, 2, 3, 5, 6, 8, 9)

Metabolites and
signaling molecules

Eicosanoid

CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane

Other

Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate · Lysophosphatidic acid (1, 2, 3, 4, 5, 6) · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate

Peptide

Neuropeptide

B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)

Other

Anaphylatoxin (C3a, C5a) · Angiotensin (1, 2) · Apelin · Bombesin (BRS3, GRPR, NMBR) · Bradykinin (B1, B2) · Chemokine · Cholecystokinin (A, B) · Endothelin (A, B) · Formyl peptide (1, 2, 3) · FSH · Galanin (1, 2, 3) · GHB receptor · Gonadotropin-releasing hormone (1, 2) · Ghrelin · Kisspeptin · Luteinizing hormone/choriogonadotropin · MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortin (1, 2, 3, 4, 5) · MCHR (1, 2) · Motilin · Opioid (Delta, Kappa, Mu, Nociceptin & Zeta, but not Sigma) · Orexin (1, 2) · Oxytocin · Prokineticin (1, 2) · Prolactin-releasing peptide · Relaxin (1, 2, 3, 4) · Somatostatin (1, 2, 3, 4, 5) · Tachykinin (1, 2, 3) · Thyrotropin · Thyrotropin-releasing hormone · Urotensin-II · Vasopressin (1A, 1B, 2)

Miscellaneous

Orphan

GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)

Other

Adrenomedullin · Olfactory · Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Protease-activated (1, 2, 3, 4) · SREB (1, 2, 3)

Class B: Secretin like

Orphan

GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)

Other

Brain-specific angiogenesis inhibitor (1, 2, 3) · Cadherin (1, 2, 3) · Calcitonin · CALCRL · CD97 · Corticotropin-releasing hormone (1, 2) · EMR (1, 2, 3) · Glucagon (GR, GIPR, GLP1R, GLP2R) · Growth hormone releasing hormone · PACAPR1 · GPR · Latrophilin (1, 2, 3, ELTD1) · Methuselah-like proteins · Parathyroid hormone (1, 2) · Secretin · Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic
glutamate / pheromone

Taste

TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)

Other

Calcium-sensing receptor · GABA B (1, 2) · Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) · GPRC6A · GPR (156, 158, 179) · RAIG (1, 2, 3, 4)

Class F:
Frizzled / Smoothened

Frizzled

Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)

Smoothened

Smoothened

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

v · d · eNeuropeptidergics

Cholecystokinin

CCK_A

Agonists: Cholecystokinin • CCK-4
Antagonists: Asperlicin • Proglumide • Lorglumide • Devazepide • Dexloxiglumide

CCK_B

Agonists: Cholecystokinin • CCK-4 • Gastrin
Antagonists: Proglumide • CI-988

CRH

CRF₁

Agonists: Corticotropin releasing hormone
Antagonists: Antalarmin • CP-154,526 • Pexacerfont

CRF₂

Agonists: Corticotropin releasing hormone

Galanin

GAL₁

Agonists: Galanin • Galanin-like peptide • Galmic • Galnon

GAL₂

Agonists: Galanin • Galanin-like peptide • Galmic • Galnon

GAL₃

Agonists: Galanin • Galmic • Galnon

Ghrelin
Agonists: Ghrelin • Capromorelin • MK-677 • Sermorelin • SM-130,686 • Tabimorelin

MCH

MCH₁

Agonists: Melanin concentrating hormone
Antagonists: ATC-0175 • GW-803,430 • NGD-4715 • SNAP-7941 • SNAP-94847

MCH₂

Agonists: Melanin concentrating hormone

Melanocortin

MC₁

Agonists: alpha-MSH • Afamelanotide • Bremelanotide • Melanotan II
Antagonists: Agouti signalling peptide

MC₂

Agonists: ACTH • Cosyntropin • Tetracosactide

MC₃

Agonists: alpha-MSH • Bremelanotide • Melanotan II

MC₄

Agonists: alpha-MSH • Bremelanotide • Melanotan II • THIQ
Antagonists: Agouti-related peptide

MC₅

Agonists: alpha-MSH • Melanotan II

Neuropeptide S
Agonists: Neuropeptide S
Antagonists: SHA-68

Neuropeptide Y

Y₁

Agonists: Neuropeptide Y • Peptide YY
Antagonists: BIBP-3226

Y₂

Agonists: Neuropeptide Y • Peptide YY
Antagonists: BIIE-0246

Y₄

Agonists: Neuropeptide Y • Pancreatic polypeptide • Peptide YY
Antagonists: UR-AK49

Y₅

Agonists: Neuropeptide Y • Peptide YY
Antagonists: Lu AA-33810

Neurotensin

NTS₁

Agonists: Neurotensin • Neuromedin N
Antagonists: SR-48692 • SR-142,948

NTS₂

Agonists: Neurotensin
Antagonists: Levocabastine • SR-142,948

Opioid
see Template:Opioids

Orexin

OX₁

Agonists: Orexin-A
Antagonists: Almorexant • SB-334,867 • SB-408,124 • SB-649,868 • Suvorexant

OX₂

Agonists: Orexin-A
Antagonists: Almorexant • SB-649,868 • Suvorexant • TCS-OX2-29

Oxytocin
Agonists: Carbetocin • Demoxytocin • Oxytocin • WAY-267,464
Antagonists: Atosiban • Epelsiban • L-371,257 • L-368,899

Tachykinin

NK₁

Agonists: Substance P
Antagonists: Aprepitant • Befetupitant • Casopitant • CI-1021 • CP-96,345 • CP-99,994 • CP-122,721 • Dapitant • Ezlopitant • FK-888 • Fosaprepitant • GR-203,040 • GW-597,599 • HSP-117 • L-733,060 • L-741,671 • L-743,310 • L-758,298 • Lanepitant • LY-306,740 • Maropitant • Netupitant • NKP-608 • Nolpitantium • Orvepitant • RP-67,580 • SDZ NKT 343 • Vestipitant • Vofopitant

NK₂

Agonists: Neurokinin A
Antagonists: GR-159,897 • Ibodutant • Saredutant

NK₃

Agonists: Neurokinin B
Antagonists: Osanetant • Talnetant

Vasopressin

V_1A

Agonists: Desmopressin • Felypressin • Ornipressin • Terlipressin • Vasopressin
Antagonists: Conivaptan • Demeclocycline • Relcovaptan

V_1B

Agonists: Felypressin • Ornipressin • Terlipressin • Vasopressin
Antagonists: Demeclocycline • Nelivaptan

V₂

Agonists: Desmopressin • Ornipressin • Vasopressin
Antagonists: Conivaptan • Demeclocycline • Lixivaptan • Mozavaptan • Satavaptan • Tolvaptan

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Academic Dictionaries and Encyclopedias

Melanin-concentrating hormone receptor

Contents

Clinical significance

References

See also

External links

Look at other dictionaries:

Share the article and excerpts

melanin-concentrating hormone receptor 1
Identifiers
Symbol	MCHR1
Alt. symbols	GPR24
Entrez	2847
HUGO	4479
OMIM	601751
RefSeq	NM_005297
UniProt	Q99705
Other data
Locus	Chr. 22 q13.3

melanin-concentrating hormone receptor 2
Identifiers
Symbol	MCHR2
Alt. symbols	GPR145
Entrez	84539
HUGO	20867
OMIM	606111
RefSeq	NM_032503
UniProt	Q969V1
Other data
Locus	Chr. 6 q16

Academic Dictionaries and Encyclopedias

Wikipedia

Melanin-concentrating hormone receptor

Contents

Clinical significance

References

See also

External links

Look at other dictionaries:

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