Methuselah-like proteins

Methuselah-like proteins
Methuselah N-terminus
PDB 1fjr EBI.jpg
Structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan.[1]
Identifiers
Symbol Methuselah_N
Pfam PF06652
InterPro IPR010596
SCOP 1fjr

The Methuselah-like proteins are a family of G protein-coupled receptors found in insects that play a role in aging and reproduction. Antagonizing these receptors can extend the life span of the animal and make it more resistant to free radicals and starvation, but also reduce reproduction and increase cold sensitivity. The age dependent decline in olfaction and motor function is unaffected.[2]

Methuselah-like proteins are related to G protein-coupled receptors of the secretin receptor family.[1]

References

  1. ^ a b West AP, Llamas LL, Snow PM, Benzer S, Bjorkman PJ (March 2001). "Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan". Proc. Natl. Acad. Sci. U.S.A. 98 (7): 3744–9. doi:10.1073/pnas.051625298. PMC 31123. PMID 11274391. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=31123. 
  2. ^ Alic N, Partridge L (2007). "Antagonizing Methuselah to extend life span". Genome Biology 8 (8): 222. doi:10.1186/gb-2007-8-8-222. PMC 2374980. PMID 17764591. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2374980. 
Metabolites and
signaling molecules
CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other
Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate
Peptide
B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other
Miscellaneous
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other
Adrenomedullin · Olfactory · Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Protease-activated (1, 2, 3, 4) · SREB (1, 2, 3)
Class B: Secretin like
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other
Class C: Metabotropic
glutamate / pheromone
TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other
Class F:
Frizzled / Smoothened
Frizzled
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)

Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • Methuselah (disambiguation) — Methuselah, a Biblical figure, was known for living a long time. Methuselah may also refer to: Long lived organisms: Methuselah (tree), a bristlecone pine in the White Mountains of California, the oldest known living organism Methuselah (Judean… …   Wikipedia

  • D1-like receptor — The D1 like receptors are a subfamily of dopamine receptors that bind the endogenous neurotransmitter dopamine. The D1 like subfamily consists of two G protein coupled receptors which are coupled to Gs and mediate excitatory neurotransmission,… …   Wikipedia

  • D2-like receptor — The D2 like receptors are a subfamily of dopamine receptors that bind the endogenous neurotransmitter dopamine. The D2 like subfamily consists of three G protein coupled receptors which are coupled to Gi/Go and mediate inhibitory… …   Wikipedia

  • Cell surface receptor — The seven transmembrane α helix structure of a G protein coupled receptor Cell surface receptors (membrane receptors, transmembrane receptors) are specialized integral membrane proteins that take part in communication between the cell and the… …   Wikipedia

  • Muscarinic acetylcholine receptor — Amanita muscaria, the mushroom from which muscarine was isolated …   Wikipedia

  • Neurotransmitter receptor — Figure 1. The seven transmembrane α helix structure of a G protein coupled receptor. A Neurotransmitter receptor is a membrane receptor protein[1] that is activated by a Neurotransmitter …   Wikipedia

  • Opsin — Three dimensional structure of bovine rhodopsin. The seven transmembrane domains are shown in varying colors. The chromophore is shown in red. Opsins are a group of light sensitive 35–55 kDa membrane bound G protein coupled receptors of the… …   Wikipedia

  • Metabotropic glutamate receptor — fluorescent micrographs of cells expressing mGluR1 labeled with green fluorescent protein[1] The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are active through an indirect metabotropic process. They are… …   Wikipedia

  • FSH-receptor — Follicle stimulating hormone receptor PDB rendering based on 1xwd …   Wikipedia

  • Olfactory receptor — Olfactory receptors expressed in the cell membranes of olfactory receptor neurons are responsible for the detection of odor molecules. Activated olfactory receptors are the initial player in a signal transduction cascade which ultimately produces …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”