CELSR1

Cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila), also known as CELSR1, is a human gene.cite web | title = Entrez Gene: CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9620| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. This particular member is a developmentally regulated, neural-specific gene which plays an unspecified role in early embryogenesis.cite web | title = Entrez Gene: CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9620| accessdate = ]

ee also

* Flamingo (protein)

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nollet F, Kools P, van Roy F |title=Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. |journal=J. Mol. Biol. |volume=299 |issue= 3 |pages= 551–72 |year= 2000 |pmid= 10835267 |doi= 10.1006/jmbi.2000.3777
*cite journal | author=Hadjantonakis AK, Sheward WJ, Harmar AJ, "et al." |title=Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter. |journal=Genomics |volume=45 |issue= 1 |pages= 97–104 |year= 1997 |pmid= 9339365 |doi= 10.1006/geno.1997.4892
*cite journal | author=Wu Q, Maniatis T |title=A striking organization of a large family of human neural cadherin-like cell adhesion genes. |journal=Cell |volume=97 |issue= 6 |pages= 779–90 |year= 1999 |pmid= 10380929 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Wu Q, Maniatis T |title=Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3124–9 |year= 2000 |pmid= 10716726 |doi= 10.1073/pnas.060027397
*cite journal | author=Ghosh A |title=Dentritic growth: don't go says flamingo. |journal=Neuron |volume=28 |issue= 1 |pages= 3–4 |year= 2000 |pmid= 11086974 |doi=
*cite journal | author=Gross J, Grimm O, Ortega G, "et al." |title=Mutational analysis of the neuronal cadherin gene CELSR1 and exclusion as a candidate for catatonic schizophrenia in a large family. |journal=Psychiatr. Genet. |volume=11 |issue= 4 |pages= 197–200 |year= 2002 |pmid= 11807409 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Georgieva L, Nikolov I, Poriazova N, "et al." |title=Genetic variation in the seven-pass transmembrane cadherin CELSR1: lack of association with schizophrenia. |journal=Psychiatr. Genet. |volume=13 |issue= 2 |pages= 103–6 |year= 2004 |pmid= 12782967 |doi= 10.1097/01.ypg.0000057486.14812.03
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Carroll JS, Liu XS, Brodsky AS, "et al." |title=Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. |journal=Cell |volume=122 |issue= 1 |pages= 33–43 |year= 2005 |pmid= 16009131 |doi= 10.1016/j.cell.2005.05.008

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