EGF-like domain

EGF-like domain

Pfam_box
Symbol = EGF
Name = EGF-like domain


width =
caption =
Pfam= PF00008
InterPro= IPR006209
SMART=
PROSITE = PDOC00021
SCOP = 1apo
TCDB =
OPM family=
OPM protein= 1dan
PDB=PDB3|1tpg :86-119 PDB3|1haf :182-221 PDB3|1hae :182-221PDB3|1hrf :182-221 PDB3|1hre :182-221 PDB3|1tozA:456-487PDB3|1wv7L:110-141 PDB3|1j9cL:110-141 PDB3|1ff7A:110-141PDB3|1wqvL:110-141 PDB3|1bf9 :110-141 PDB3|1f7mA:110-141PDB3|1wssL:110-141 PDB3|1nl8M:110-141 PDB3|1w0yL:110-141PDB3|1dvaM:110-141 PDB3|1z6jL:110-141 PDB3|1fakL:110-141PDB3|1f7eA:110-141 PDB3|1wunL:110-141 PDB3|1wtgL:110-141PDB3|1qfkL:110-141 PDB3|1o5dL:110-141 PDB3|1ffmA:110-141PDB3|1danL:110-141 PDB3|1xkbB:90-121 PDB3|1xkaL:90-121PDB3|1apo :90-121 PDB3|1whf :90-121 PDB3|1whe :90-121PDB3|1ccf :90-121 PDB3|1edmC:97-128 PDB3|1ixa :97-128PDB3|1pfxL:52-83 PDB3|1x7aL:52-83 PDB3|1pz8C:1836-1869PDB3|1q56A:1836-1869 PDB3|1pz7B:1836-1869 PDB3|1pz9B:1836-1869PDB3|1pgfB:37-69 PDB3|1pthA:37-69 PDB3|1prhB:37-69PDB3|1q4gB:37-69 PDB3|1pggA:37-69 PDB3|1ebvA:37-69PDB3|1fe2A:37-69 PDB3|1ht5B:37-69 PDB3|1cqeB:37-69PDB3|1diyA:37-69 PDB3|2aylA:37-69 PDB3|1eqgA:37-69PDB3|1pgeA:37-69 PDB3|1igzA:37-69 PDB3|1ht8A:37-69PDB3|1eqhB:37-69 PDB3|1igxA:37-69 PDB3|1u67A:37-69PDB3|1djjA:37-69 PDB3|1pxxB:21-54 PDB3|5coxC:21-54PDB3|1ddxA:21-54 PDB3|1cvuA:21-54 PDB3|1dd0A:21-54PDB3|1cx2B:21-54 PDB3|3pghC:21-54 PDB3|4coxB:21-54PDB3|1dcxB:21-54 PDB3|6coxB:21-54 PDB3|1v0xA:22-54PDB3|1g1qA:163-194 PDB3|1g1sB:163-194 PDB3|1g1rB:163-194PDB3|1fsb :163-194 PDB3|1esl :143-174 PDB3|1g1tA:143-174PDB3|1nziA:135-171 PDB3|1k36A:68-103 PDB3|1k37A:68-103PDB3|1ivoD:976-1012 PDB3|1jl9B:976-1012 PDB3|1nqlB:976-1012PDB3|1a3p :982-1018 PDB3|1epj :982-1018 PDB3|1epg :982-1018PDB3|3egf :982-1018 PDB3|1egf :982-1018 PDB3|1eph :982-1018PDB3|1epi :982-1018 PDB3|1ioxA:69-104 PDB3|1ip0A:69-104PDB3|4tgf :47-82 PDB3|2tgf :47-82 PDB3|1moxD:47-82PDB3|1yug :47-82 PDB3|1yuf :47-82 PDB3|3tgf :47-82PDB3|1xdtR:108-143 PDB3|1ijqA:667-711 PDB3|1n7dA:667-711PDB3|1xfeA:318-352 PDB3|1i0uA:318-352 PDB3|1hj7A:318-352PDB3|1hz8A:318-352 PDB3|1rfnB:134-170 PDB3|1ezqB:129-164PDB3|1c5mF:129-164 PDB3|1ksnB:129-164 PDB3|1ioeL:129-164PDB3|2bokL:129-164 PDB3|1hcgB:129-164 PDB3|1iqjL:129-164PDB3|1iqlL:129-164 PDB3|1nfuB:129-164 PDB3|1faxL:129-164PDB3|1lpzA:129-164 PDB3|1f0rB:129-164 PDB3|1g2lB:129-164PDB3|1g2mB:129-164 PDB3|1nfwB:129-164 PDB3|1p0sL:129-164PDB3|1nfxB:129-164 PDB3|1v3xB:129-164 PDB3|1iqkL:129-164PDB3|1lqdA:129-164 PDB3|1lpkA:129-164 PDB3|1nfyB:129-164PDB3|1iqgL:129-164 PDB3|1wu1B:129-164 PDB3|1fjsL:129-164PDB3|1lpgA:129-164 PDB3|1iqhL:129-164 PDB3|1iqiL:129-164PDB3|1f0sB:129-164 PDB3|1mq5L:129-164 PDB3|1iqmL:129-164PDB3|1iqeL:129-164 PDB3|1iqfL:129-164 PDB3|1iqnL:129-164PDB3|1mq6L:129-164 PDB3|1kyeB:129-164 PDB3|1kigL:129-164PDB3|1yo8A:652-691 PDB3|1gl4A:388-423 PDB3|1h4uA:395-423PDB3|1cejA:1574-1617 PDB3|1ob1F:474-517

EGF-like domain is an evolutionary conserved protein domain, of about thirty to forty amino-acid residues long, which was found in a large number of mostly animal proteins. All these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (except in prostaglandin H/G synthase). The EGF domain includes six cysteine residues which have been shown (in EGF) to be involved in three disulfide bonds. The main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet.

Pfam|PF00053 family is very similar, but has 8 instead of 6conserved cysteines.

This family includes some cytokine receptors.

Human proteins containing this domain

AGC1; AGRIN; AREG; ATRN; ATRNL1; BCAN; BMP1; BTC;
C1S; CASPR4; CD248; CD93; CELSR1; CELSR2; CELSR3; CNTNAP1;
CNTNAP2; CNTNAP3; CNTNAP4; CNTNAP5; COMP; COX-2; CRB1; CRB2;
CSPG3; CUBN; DLK1; DLL1; DLL3; DLL4; DNER; EDIL3;
EGF; EGFL11; EGFL8; EGFL9; EGFLAM; EPGN; EREG; F10;
F12; F7; F9; FAT; FAT2; FAT4; FBN1; FBN2;
FBN3; GAS6; HABP2; HBEGF; HEG1; HGFAC; HMCN1; HSPG2;
ITGB5; JAG1; JAG2; LDLR; LRP1; LRP10; LRP1B; LRP2;
LRP4; LRP5; LRP6; LRP8; LTBP1; LTBP2; LTBP3; LTBP4;
MATN1; MATN2; MATN3; MATN4; MEGF12; MEGF6; MEP1A; MEP1B;
MFGE8; MMRN; MMRN1; MUC4; NAGPA; NID1; NID2; NOTCH1;
NOTCH2; NOTCH2NL; NOTCH3; NOTCH4; NRG1; NRG2; NRG3; NRG4;
NRXN1; NRXN2; NRXN3; NTNG2; ODZ1; ODZ2; ODZ3; OIT3;
PLAT; PP187; PROC; PROS1; PROZ; PTGS1; PTGS2; RAMP;
RESDA1; SCUBE1; SCUBE2; SCUBE3; SEL-OB; SELE; SELL; SELP;
SLIT1; SLIT2; SLIT3; SNED1; STAB1; STAB2; SVEP1; TECTA;
TGFA; THBD; THBS1; THBS2; THBS4; TIE1; TLL1; TLL2;
TMEFF1; TMEFF2; TNC; TNXB; UMOD; VASN; VCAN; VLDLR;
VWA2; WIF1; ZAN; dJ34F7.1;

References

* [1] . Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders. Downing AK, Knott V, Werner JM, Cardy CM, Campbell ID, Handford PA; Cell 1996;85:597-605. PMID|8653794
* [2] . Structure and distribution of modules in extracellular proteins. Bork P, Downing AK, Kieffer B, Campbell ID; Q Rev Biophys 1996;29:119-167. PMID|8870072

ee also

*Epidermal growth factor


Wikimedia Foundation. 2010.

Игры ⚽ Нужна курсовая?

Look at other dictionaries:

  • EGF-like domain — Region of 30 40 amino acids containing 6 cysteines found originally in EGF, and also in a range of proteins involved in cell signalling. Examples: TGF a, amphiregulin, urokinase, tissue plasminogen activator, complement C6 C9, fibronectin,… …   Dictionary of molecular biology

  • Heparin-binding EGF-like growth factor — PDB rendering based on 1xdt …   Wikipedia

  • EGF module-containing mucin-like hormone receptor — protein Name = egf like module containing, mucin like, hormone receptor like 1 caption = width = HGNCid = 3336 Symbol = EMR1 AltSymbols = TM7LN3 EntrezGene = 2015 OMIM = 600493 RefSeq = NM 001974 UniProt = Q14246 PDB = ECnumber = Chromosome = 19… …   Wikipedia

  • EGF — See epidermal growth factor, EGF like domain …   Dictionary of molecular biology

  • EGFL7 — EGF like domain, multiple 7, also known as EGFL7, is a human gene.cite web | title = Entrez Gene: EGFL7 EGF like domain, multiple 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=51162| accessdate = ] PBB… …   Wikipedia

  • Factor VII — Coagulation factor VII (serum prothrombin conversion accelerator) Anchoring of coagulation factor VIIa to the membrane through its Gla domain …   Wikipedia

  • Neuregulin 1 — PDB rendering based on 1hae …   Wikipedia

  • PDGFC — Platelet derived growth factor C Identifiers Symbols PDGFC; FALLOTEIN; SCDGF External IDs …   Wikipedia

  • Platelet-derived growth factor — (PDGF) Identifiers Symbol PDGF Pfam PF00341 InterPro …   Wikipedia

  • Mitogen-activated protein kinase — Identifiers EC number 2.7.11.24 CAS number 142243 02 5 …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”