EGF-like domain

EGF-like domain is an evolutionary conserved protein domain, of about thirty to forty amino-acid residues long, which was found in a large number of mostly animal proteins. All these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (except in prostaglandin H/G synthase). The EGF domain includes six cysteine residues which have been shown (in EGF) to be involved in three disulfide bonds. The main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet.

Pfam|PF00053 family is very similar, but has 8 instead of 6conserved cysteines.

This family includes some cytokine receptors.

Human proteins containing this domain

AGC1; AGRIN; AREG; ATRN; ATRNL1; BCAN; BMP1; BTC;
C1S; CASPR4; CD248; CD93; CELSR1; CELSR2; CELSR3; CNTNAP1;
CNTNAP2; CNTNAP3; CNTNAP4; CNTNAP5; COMP; COX-2; CRB1; CRB2;
CSPG3; CUBN; DLK1; DLL1; DLL3; DLL4; DNER; EDIL3;
EGF; EGFL11; EGFL8; EGFL9; EGFLAM; EPGN; EREG; F10;
F12; F7; F9; FAT; FAT2; FAT4; FBN1; FBN2;
FBN3; GAS6; HABP2; HBEGF; HEG1; HGFAC; HMCN1; HSPG2;
ITGB5; JAG1; JAG2; LDLR; LRP1; LRP10; LRP1B; LRP2;
LRP4; LRP5; LRP6; LRP8; LTBP1; LTBP2; LTBP3; LTBP4;
MATN1; MATN2; MATN3; MATN4; MEGF12; MEGF6; MEP1A; MEP1B;
MFGE8; MMRN; MMRN1; MUC4; NAGPA; NID1; NID2; NOTCH1;
NOTCH2; NOTCH2NL; NOTCH3; NOTCH4; NRG1; NRG2; NRG3; NRG4;
NRXN1; NRXN2; NRXN3; NTNG2; ODZ1; ODZ2; ODZ3; OIT3;
PLAT; PP187; PROC; PROS1; PROZ; PTGS1; PTGS2; RAMP;
RESDA1; SCUBE1; SCUBE2; SCUBE3; SEL-OB; SELE; SELL; SELP;
SLIT1; SLIT2; SLIT3; SNED1; STAB1; STAB2; SVEP1; TECTA;
TGFA; THBD; THBS1; THBS2; THBS4; TIE1; TLL1; TLL2;
TMEFF1; TMEFF2; TNC; TNXB; UMOD; VASN; VCAN; VLDLR;
VWA2; WIF1; ZAN; dJ34F7.1;

References

* [1] . Solution structure of a pair of calcium-binding epidermal growth factor-like domains: implications for the Marfan syndrome and other genetic disorders. Downing AK, Knott V, Werner JM, Cardy CM, Campbell ID, Handford PA; Cell 1996;85:597-605. PMID|8653794
* [2] . Structure and distribution of modules in extracellular proteins. Bork P, Downing AK, Kieffer B, Campbell ID; Q Rev Biophys 1996;29:119-167. PMID|8870072

ee also

*Epidermal growth factor

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EGF-like domain

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