Arginine vasopressin receptor 1A

Arginine vasopressin receptor 1A

Arginine vasopressin receptor 1A (AVPR1A) is a protein that acts as receptor for arginine vasopressin.cite journal | author = Thibonnier M, Auzan C, Madhun Z, Wilkins P, Berti-Mattera L, Clauser E | title = Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor | journal = J. Biol. Chem. | volume = 269 | issue = 5 | pages = 3304–10 | year = 1994 | pmid = 8106369 | doi = | issn = | url = ] AVPR1A belongs to the subfamily of G-protein coupled receptors.

Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system.

The activity / genetic variants of the AVPR1 gene might be related to generosity and altruistic behavior.cite journal | author = Knafo A, Israel S, Darvasi A, Bachner-Melman R, Uzefovsky F, Cohen L, Feldman E, Lerer E, Laiba E, Raz Y, Nemanov L, Gritsenko I, Dina C, Agam G, Dean B, Bornstein G, Ebstein RP | title = Individual differences in allocation of funds in the dictator game associated with length of the arginine vasopressin 1a receptor RS3 promoter region and correlation between RS3 length and hippocampal mRNA | journal = Genes Brain Behav | volume = | issue = | pages = | year = 2007 | pmid = 17696996 | doi = 10.1111/j.1601-183X.2007.00341.x | issn = ] NatureNews has referred to AVPR1a as the "ruthlessness gene".cite journal | author = | title = 'Ruthlessness gene' discovered | journal = Nature@News | volume = | issue = | pages = | year = 2008 | month = April | pmid = | doi = 10.1038/news.2008.738 | url = | issn = | quote = Dictatorial behaviour may be partly genetic, study suggests ]


Further reading

citations =
*cite journal | author=Thibonnier M, Coles P, Thibonnier A, Shoham M |title=Molecular pharmacology and modeling of vasopressin receptors. |journal=Prog. Brain Res. |volume=139 |issue= |pages= 179–96 |year= 2002 |pmid= 12436935 |doi=
*cite journal | author=Cross SH, Charlton JA, Nan X, Bird AP |title=Purification of CpG islands using a methylated DNA binding column. |journal=Nat. Genet. |volume=6 |issue= 3 |pages= 236–44 |year= 1994 |pmid= 8012384 |doi= 10.1038/ng0394-236
*cite journal | author=Hirasawa A, Shibata K, Kotosai K, Tsujimoto G |title=Cloning, functional expression and tissue distribution of human cDNA for the vascular-type vasopressin receptor. |journal=Biochem. Biophys. Res. Commun. |volume=203 |issue= 1 |pages= 72–9 |year= 1994 |pmid= 8074728 |doi= 10.1006/bbrc.1994.2150
*cite journal | author=Thibonnier M, Auzan C, Madhun Z, "et al." |title=Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor. |journal=J. Biol. Chem. |volume=269 |issue= 5 |pages= 3304–10 |year= 1994 |pmid= 8106369 |doi=
*cite journal | author=Young WS, Kovács K, Lolait SJ |title=The diurnal rhythm in vasopressin V1a receptor expression in the suprachiasmatic nucleus is not dependent on vasopressin. |journal=Endocrinology |volume=133 |issue= 2 |pages= 585–90 |year= 1993 |pmid= 8344200 |doi=
*cite journal | author=Thibonnier M, Graves MK, Wagner MS, "et al." |title=Structure, sequence, expression, and chromosomal localization of the human V1a vasopressin receptor gene. |journal=Genomics |volume=31 |issue= 3 |pages= 327–34 |year= 1997 |pmid= 8838314 |doi= 10.1006/geno.1996.0055
*cite journal | author=North WG, Fay MJ, Longo K, Du J |title=Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma. |journal=Peptides |volume=18 |issue= 7 |pages= 985–93 |year= 1998 |pmid= 9357056 |doi=
*cite journal | author=North WG, Fay MJ, Longo KA, Du J |title=Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide. |journal=Cancer Res. |volume=58 |issue= 9 |pages= 1866–71 |year= 1998 |pmid= 9581826 |doi=
*cite journal | author=North WG, Fay MJ, Du J |title=MCF-7 breast cancer cells express normal forms of all vasopressin receptors plus an abnormal V2R. |journal=Peptides |volume=20 |issue= 7 |pages= 837–42 |year= 1999 |pmid= 10477084 |doi=
*cite journal | author=Tahara A, Tsukada J, Ishii N, "et al." |title=Comparison of vasopressin binding sites in human uterine and vascular smooth muscle cells. |journal=Eur. J. Pharmacol. |volume=378 |issue= 1 |pages= 137–42 |year= 1999 |pmid= 10478574 |doi=
*cite journal | author=Thibonnier M, Graves MK, Wagner MS, "et al." |title=Study of V(1)-vascular vasopressin receptor gene microsatellite polymorphisms in human essential hypertension. |journal=J. Mol. Cell. Cardiol. |volume=32 |issue= 4 |pages= 557–64 |year= 2000 |pmid= 10756113 |doi= 10.1006/jmcc.2000.1108
*cite journal | author=Berrada K, Plesnicher CL, Luo X, Thibonnier M |title=Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27229–37 |year= 2000 |pmid= 10858434 |doi= 10.1074/jbc.M002288200
*cite journal | author=Kim SJ, Young LJ, Gonen D, "et al." |title=Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism. |journal=Mol. Psychiatry |volume=7 |issue= 5 |pages= 503–7 |year= 2002 |pmid= 12082568 |doi= 10.1038/
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tahtaoui C, Balestre MN, Klotz P, "et al." |title=Identification of the binding sites of the SR49059 nonpeptide antagonist into the V1a vasopressin receptor using sulfydryl-reactive ligands and cysteine mutants as chemical sensors. |journal=J. Biol. Chem. |volume=278 |issue= 41 |pages= 40010–9 |year= 2003 |pmid= 12869559 |doi= 10.1074/jbc.M301128200
*cite journal | author=Hawtin SR, Wesley VJ, Simms J, "et al." |title=An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist. |journal=Eur. J. Biochem. |volume=270 |issue= 23 |pages= 4681–8 |year= 2004 |pmid= 14622255 |doi=
*cite journal | author=Terrillon S, Barberis C, Bouvier M |title=Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 6 |pages= 1548–53 |year= 2004 |pmid= 14757828 |doi= 10.1073/pnas.0305322101
*cite journal | author=Wassink TH, Piven J, Vieland VJ, "et al." |title=Examination of AVPR1a as an autism susceptibility gene. |journal=Mol. Psychiatry |volume=9 |issue= 10 |pages= 968–72 |year= 2005 |pmid= 15098001 |doi= 10.1038/
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

External links

* [ IUPHAR GPCR Database - Arginine vasopressin receptor V1A]

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