Arginine vasopressin receptor 1B

Arginine vasopressin receptor 1B (AVPR1B, vasopressin 3 receptor) is a protein that acts as receptor for arginine vasopressin. AVPR1B belongs to the subfamily of G-protein coupled receptors. Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system.

Tissue distribution

AVPR1B was initially described as a novel vasopressin receptor located in the anterior pituitary, where it stimulates ACTH release.cite journal | author = Antoni FA, Holmes MC, Makara GB, Kárteszi M, László FA | title = Evidence that the effects of arginine-8-vasopressin (AVP) on pituitary corticotropin (ACTH) release are mediated by a novel type of receptor | journal = Peptides | volume = 5 | issue = 3 | pages = 519–22 | year = 1984 | pmid = 6089144 | doi = 10.1016/0196-9781(84)90080-9 | issn = ] Subsequent studies have shown its presence in the brain as well.cite journal | author = Hernando F, Schoots O, Lolait SJ, Burbach JP | title = Immunohistochemical localization of the vasopressin V_1b receptor in the rat brain and pituitary gland: anatomical support for its involvement in the central effects of vasopressin | journal = Endocrinology | volume = 142 | issue = 4 | pages = 1659–68 | year = 2001 | pmid = 11250948 | doi = 10.1210/en.142.4.1659 | issn = ] cite journal | author = Young WS, Li J, Wersinger SR, Palkovits M | title = The vasopressin 1b receptor is prominent in the hippocampal area CA2 where it is unaffected by restraint stress or adrenalectomy | journal = Neuroscience | volume = 143 | issue = 4 | pages = 1031–9 | year = 2006 | pmid = 17027167 | doi = 10.1016/j.neuroscience.2006.08.040 | issn = ]

Clinical significance

Behavioral

Inactivation of the Avpr1b in mice (knockout) produces mice with greatly reduced aggression and a reduced ability to recognize recently investigated mice.cite journal | author = Wersinger SR, Ginns EI, O'Carroll AM, Lolait SJ, Young WS | title = Vasopressin V_1b receptor knockout reduces aggressive behavior in male mice | journal = Mol. Psychiatry | volume = 7 | issue = 9 | pages = 975–84 | year = 2002 | pmid = 12399951 | doi = 10.1038/sj.mp.4001195 | issn = ] Interestingly, defensive behavior and predatory behaviors appear to normal in these knockout mice.cite journal | author = Wersinger SR, Caldwell HK, Christiansen M, Young WS | title = Disruption of the vasopressin 1b receptor gene impairs the attack component of aggressive behavior in mice | journal = Genes Brain Behav. | volume = 6 | issue = 7 | pages = 653–60 | year = 2007 | pmid = 17284170 | doi = 10.1111/j.1601-183X.2006.00294.x | issn = ] There is evidence that social motivation or awareness is reduced in these mice.cite journal | author = Wersinger SR, Kelliher KR, Zufall F, Lolait SJ, O'Carroll AM, Young WS | title = Social motivation is reduced in vasopressin 1b receptor null mice despite normal performance in an olfactory discrimination task | journal = Hormones and Behavior | volume = 46 | issue = 5 | pages = 638–45 | year = 2004 | pmid = 15555506 | doi = 10.1016/j.yhbeh.2004.07.004 | issn = ] The AVPR1B antagonist, SSR149415, has been shown to have anti-aggressive actions in hamsterscite journal | author = Blanchard RJ, Griebel G, Farrokhi C, Markham C, Yang M, Blanchard DC | title = AVP V_1b selective antagonist SSR149415 blocks aggressive behaviors in hamsters | journal = Pharmacol. Biochem. Behav. | volume = 80 | issue = 1 | pages = 189–94 | year = 2005 | pmid = 15652395 | doi = 10.1016/j.pbb.2004.10.024 | issn = ] and anti-depressant- and anxiety (anxiolytic)-like behaviors in rats.cite journal | author = Serradeil-Le Gal C, Wagnon J, Tonnerre B, Roux R, Garcia G, Griebel G, Aulombard A | title = An overview of SSR149415, a selective nonpeptide vasopressin V_1b receptor antagonist for the treatment of stress-related disorders | journal = CNS Drug Reviews | volume = 11 | issue = 1 | pages = 53–68 | year = 2005 | pmid = 15867952 | doi = 10.1111/j.1527-3458.2005.tb00035.x | issn = ] A single nucleotide polymorphism (SNP) has been associated with susceptiblility to depression in man.cite journal | author = van West D, Del-Favero J, Aulchenko Y, Oswald P, Souery D, Forsgren T, Sluijs S, Bel-Kacem S, Adolfsson R, Mendlewicz J, Van Duijn C, Deboutte D, Van Broeckhoven C, Claes S | title = A major SNP haplotype of the arginine vasopressin 1B receptor protects against recurrent major depression | journal = Mol. Psychiatry | volume = 9 | issue = 3 | pages = 287–92 | year = 2004 | pmid = 15094789 | doi = 10.1038/sj.mp.4001420 | issn = ]

Metabolic

Various stress-induced elevations of ACTH are blunted in the Avpr1b knockout mouse.cite journal | author = Lolait SJ, Stewart LQ, Jessop DS, Young WS, O'Carroll AM | title = The hypothalamic-pituitary-adrenal axis response to stress in mice lacking functional vasopressin V1b receptors | journal = Endocrinology | volume = 148 | issue = 2 | pages = 849–56 | year = 2007 | pmid = 17122081 | doi = 10.1210/en.2006-1309 | issn = ]

Oncology

AVPR1B is expressed at high levels in ACTH-secreting pituitary adenomas as well as in bronchial carcinoidscite journal | author = Arlt W, Dahia PL, Callies F, Nordmeyer JP, Allolio B, Grossman AB, Reincke M | title = Ectopic ACTH production by a bronchial carcinoid tumour responsive to desmopressin in vivo and in vitro | journal = Clin. Endocrinol. (Oxf) | volume = 47 | issue = 5 | pages = 623–7 | year = 1997 | pmid = 9425403 | doi = 10.1046/j.1365-2265.1997.3091129.x | issn = ] responsible for the ectopic ACTH syndrome.cite journal | author = de Keyzer Y, Lenne F, Auzan C, Jégou S, René P, Vaudry H, Kuhn JM, Luton JP, Clauser E, Bertagna X | title = The pituitary V3 vasopressin receptor and the corticotroph phenotype in ectopic ACTH syndrome | journal = J. Clin. Invest. | volume = 97 | issue = 5 | pages = 1311–8 | year = 1996 | pmid = 8636444 | doi = | issn = | url = http://www.jci.org/cgi/content/abstract/97/5/1311 ]

Ligands

SSR149415cite journal | author = Serradeil-Le Gal C, Wagnon J, Simiand J, Griebel G, Lacour C, Guillon G, Barberis C, Brossard G, Soubrié P, Nisato D, Pascal M, Pruss R, Scatton B, Maffrand JP, Le Fur G | title = Characterization of (2S,4R)-1- [5-chloro-1- [(2,4-dimethoxyphenyl)sulfonyl] -3-(2-methoxy-phenyl)-2-oxo-2,3-dihydro-1H-indol-3-yl] -4-hydroxy-N,N-dimethyl-2-pyrrolidine carboxamide (SSR149415), a selective and orally active vasopressin V_1b receptor antagonist | journal = J. Pharmacol. Exp. Ther. | volume = 300 | issue = 3 | pages = 1122–30 | year = 2002 | pmid = 11861823 | doi = 10.1124/jpet.300.3.1122 | issn = ] and D- [Leu⁴-Lys⁸] -vasopressincite journal | author = Pena A, Murat B, Trueba M, Ventura MA, Bertrand G, Cheng LL, Stoev S, Szeto HH, Wo N, Brossard G, Serradeil-Le Gal C, Manning M, Guillon G | title = Pharmacological and physiological characterization of d [Leu⁴, Lys⁸] vasopressin, the first V_1b-selective agonist for rat vasopressin/oxytocin receptors | journal = Endocrinology | volume = 148 | issue = 9 | pages = 4136–46 | year = 2007 | pmid = 17495006 | doi = 10.1210/en.2006-1633 | issn = ] are a specific antagonist and agonist for the vasopressin 1b receptor, respectively.

References

External links

* [http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2965 IUPHAR GPCR database - Arginine vasopressin receptor V_1B]
* MeshName|Receptors,+Vasopressin

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