Neuropeptide Y receptor Y1

Neuropeptide Y receptor Y1
Rendering based on PDB 2F1U.
Available structures PDB 2F1U, 2IIL
Identifiers
Symbols	NPY1R; NPYR
External IDs	OMIM: 162641 MGI: 104963 HomoloGene: 700 IUPHAR: Y1 GeneCards: NPY1R Gene
Gene Ontology Molecular function • peptide YY receptor activity • pancreatic polypeptide receptor activity • receptor activity • G-protein coupled receptor activity • neuropeptide Y receptor activity • protein binding Cellular component • cytosol • plasma membrane • plasma membrane • integral to plasma membrane • synaptic vesicle • axon Biological process • outflow tract morphogenesis • glucose metabolic process • G-protein signaling, coupled to cyclic nucleotide second messenger • inhibition of adenylate cyclase activity by G-protein signaling pathway • locomotory behavior • feeding behavior • regulation of blood pressure • sensory perception of pain • response to estradiol stimulus • regulation of multicellular organism growth • positive regulation of vasoconstriction • negative regulation of hormone secretion • reduction of cytosolic calcium ion concentration Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4886	18166
Ensembl	ENSG00000164128	ENSMUSG00000036437
UniProt	P25929	Q3V1K5
RefSeq (mRNA)	NM_000909	NM_010934.4
RefSeq (protein)	NP_000900	NP_035064.1
Location (UCSC)	Chr 4: 164.25 – 164.27 Mb	Chr 8: 69.22 – 69.23 Mb
PubMed search	[1]	[2]

Neuropeptide Y receptor type 1 is a protein that in humans is encoded by the NPY1R gene.^[1][2]

Selective Ligands

Agonists

• Neuropeptide Y (endogenous agonist, non subtype selective)
• Peptide YY

Antagonists

Peptide

• BVD-10 (selective NPY₁ antagonist, CAS# 262418-00-8)
• GR-231,118 (mixed NPY₁ antagonist / NPY₄ agonist, CAS# 158859-98-4)

Non-peptide

• BIBO-3304 (CAS# 191868-14-1)
• BIBP-3226 (CAS# 159013-54-4)
• PD-160,170 (CAS# 181468-88-2)

See also

• Neuropeptide Y receptor

References

1. ^ Herzog H, Baumgartner M, Vivero C, Selbie LA, Auer B, Shine J (Apr 1993). "Genomic organization, localization, and allelic differences in the gene for the human neuropeptide Y Y1 receptor". J Biol Chem 268 (9): 6703–7. PMID 8095935. 
2. ^ "Entrez Gene: NPY1R neuropeptide Y receptor Y1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4886. 

External links

• "Neuropeptide Y Receptors: Y₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2366. 

Further reading

• Wan CP, Lau BH (1997). "Neuropeptide Y receptor subtypes.". Life Sci. 56 (13): 1055–64. doi:10.1016/0024-3205(95)00041-4. PMID 9001438. 
• Parker E, Van Heek M, Stamford A (2002). "Neuropeptide Y receptors as targets for anti-obesity drug development: perspective and current status.". Eur. J. Pharmacol. 440 (2–3): 173–87. doi:10.1016/S0014-2999(02)01427-9. PMID 12007534. 
• Bettio A, Beck-Sickinger AG (2002). "Biophysical methods to study ligand-receptor interactions of neuropeptide Y". Biopolymers 60 (6): 420–37. doi:10.1002/1097-0282(2001)60:6<420::AID-BIP10183>3.0.CO;2-W. PMID 12209475. 
• Larhammar D, Blomqvist AG, Yee F et al. (1992). "Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type". J. Biol. Chem. 267 (16): 10935–8. PMID 1317848. 
• Herzog H, Hort YJ, Ball HJ et al. (1992). "Cloned human neuropeptide Y receptor couples to two different second messenger systems". Proc. Natl. Acad. Sci. U.S.A. 89 (13): 5794–8. doi:10.1073/pnas.89.13.5794. PMC 402104. PMID 1321422. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=402104. 
• Rose PM, Fernandes P, Lynch JS et al. (1995). "Cloning and functional expression of a cDNA encoding a human type 2 neuropeptide Y receptor". J. Biol. Chem. 270 (39): 22661–4. doi:10.1074/jbc.270.39.22661. PMID 7559383. 
• Gicquiaux H, Lecat S, Gaire M et al. (2002). "Rapid internalization and recycling of the human neuropeptide Y Y(1) receptor". J. Biol. Chem. 277 (8): 6645–55. doi:10.1074/jbc.M107224200. PMID 11741903. 
• Sheriff S, F Qureshy A, T Chance W et al. (2002). "Predominant role by CaM kinase in NPY Y(1) receptor signaling: involvement of CREB [corrected]". Peptides 23 (1): 87–96. doi:10.1016/S0196-9781(01)00583-6. PMID 11814622. 
• Cox HM, Tough IR (2002). "Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa". Br. J. Pharmacol. 135 (6): 1505–12. doi:10.1038/sj.bjp.0704604. PMC 1573267. PMID 11906964. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1573267. 
• Uddman R, Möller S, Nilsson T et al. (2003). "Neuropeptide Y Y1 and neuropeptide Y Y2 receptors in human cardiovascular tissues". Peptides 23 (5): 927–34. doi:10.1016/S0196-9781(02)00003-7. PMID 12084524. 
• Cantó Soler MV, Gallo JE, Dodds RA et al. (2002). "Y1 receptor of neuropeptide Y as a glial marker in proliferative vitreoretinopathy and diseased human retina". Glia 39 (3): 320–4. doi:10.1002/glia.10107. PMID 12203398. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Berglund MM, Schober DA, Statnick MA et al. (2003). "The use of bioluminescence resonance energy transfer 2 to study neuropeptide Y receptor agonist-induced beta-arrestin 2 interaction". J. Pharmacol. Exp. Ther. 306 (1): 147–56. doi:10.1124/jpet.103.051227. PMID 12665544. 
• Lehner B, Sanderson CM (2004). "A Protein Interaction Framework for Human mRNA Degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=442147. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Körner M, Waser B, Reubi JC (2005). "High expression of neuropeptide y receptors in tumors of the human adrenal gland and extra-adrenal paraganglia". Clin. Cancer Res. 10 (24): 8426–33. doi:10.1158/1078-0432.CCR-04-0821. PMID 15623622. 

Metabolites and
signaling molecules

Eicosanoid	CysLT (1, 2) · LTB4 (1, 2) · FPRL1 · OXE · Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) · Prostacyclin · Thromboxane
Other	Bile acid · Cannabinoid (CB1, CB2, GPR (18, 55, 119)) · EBI2 · Estrogen · Free fatty acid (1, 2, 3, 4) · Lactate  · Lysophosphatidic acid (1, 2, 3, 4, 5, 6)  · Lysophospholipid (1, 2, 3, 4, 5, 6, 7, 8) · Niacin (1, 2) · Oxoglutarate · PAF · Sphingosine-1-phosphate (1, 2, 3, 4, 5) · Succinate

Peptide

Neuropeptide	B/W (1, 2) · FF (1, 2) · S · Y (1, 2, 4, 5) · Neuromedin (B, U (1, 2)) · Neurotensin (1, 2)
Other	Anaphylatoxin (C3a, C5a) · Angiotensin (1, 2) · Apelin · Bombesin (BRS3, GRPR, NMBR) · Bradykinin (B1, B2) · Chemokine · Cholecystokinin (A, B) · Endothelin (A, B) · Formyl peptide (1, 2, 3) · FSH · Galanin (1, 2, 3) · GHB receptor · Gonadotropin-releasing hormone (1, 2) · Ghrelin · Kisspeptin · Luteinizing hormone/choriogonadotropin · MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) · Melanocortin (1, 2, 3, 4, 5) · MCHR (1, 2) · Motilin · Opioid (Delta, Kappa, Mu, Nociceptin & Zeta, but not Sigma) · Orexin (1, 2) · Oxytocin · Prokineticin (1, 2) · Prolactin-releasing peptide · Relaxin (1, 2, 3, 4) · Somatostatin (1, 2, 3, 4, 5) · Tachykinin (1, 2, 3) · Thyrotropin · Thyrotropin-releasing hormone · Urotensin-II · Vasopressin (1A, 1B, 2)

Miscellaneous

Orphan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Other	Adrenomedullin · Olfactory · Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) · Protease-activated (1, 2, 3, 4) · SREB (1, 2, 3)

Class B: Secretin like

Orphan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Other	Brain-specific angiogenesis inhibitor (1, 2, 3) · Cadherin (1, 2, 3) · Calcitonin · CALCRL · CD97 · Corticotropin-releasing hormone (1, 2) · EMR (1, 2, 3) · Glucagon (GR, GIPR, GLP1R, GLP2R) · Growth hormone releasing hormone · PACAPR1 · GPR · Latrophilin (1, 2, 3, ELTD1) · Methuselah-like proteins · Parathyroid hormone (1, 2) · Secretin · Vasoactive intestinal peptide (1, 2)

Class C: Metabotropic
glutamate / pheromone

Taste	TAS1R (1, 2, 3) · TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Other	Calcium-sensing receptor · GABA B (1, 2) · Glutamate receptor (Metabotropic glutamate (1, 2, 3, 4, 5, 6, 7, 8)) · GPRC6A · GPR (156, 158, 179) · RAIG (1, 2, 3, 4)

Class F:
Frizzled / Smoothened

Frizzled	Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Smoothened	Smoothened

B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)