GABBR2

Gamma-aminobutyric acid (GABA) B receptor, 2, also known as GABBR2, is a human gene.cite web | title = Entrez Gene: GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9568| accessdate = ]

PBB_Summary
section_title =
summary_text = B-type receptors for the neurotransmitter GABA (gamma-aminobutyric acid) inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters and the activity of ion channels and adenylyl cyclase. See GABBR1 (MIM 603540) for additional background information on GABA-B receptors. [supplied by OMIM] cite web | title = Entrez Gene: GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9568| accessdate = ]

ee also

* GABAB receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=White JH, Wise A, Main MJ, "et al." |title=Heterodimerization is required for the formation of a functional GABA(B) receptor. |journal=Nature |volume=396 |issue= 6712 |pages= 679–82 |year= 1999 |pmid= 9872316 |doi= 10.1038/25354
*cite journal | author=Ng GY, Clark J, Coulombe N, "et al." |title=Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity. |journal=J. Biol. Chem. |volume=274 |issue= 12 |pages= 7607–10 |year= 1999 |pmid= 10075644 |doi=
*cite journal | author=Ng GY, McDonald T, Bonnert T, "et al." |title=Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9. |journal=Genomics |volume=56 |issue= 3 |pages= 288–95 |year= 1999 |pmid= 10087195 |doi= 10.1006/geno.1998.5706
*cite journal | author=Martin SC, Russek SJ, Farb DH |title=Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1. |journal=Mol. Cell. Neurosci. |volume=13 |issue= 3 |pages= 180–91 |year= 1999 |pmid= 10328880 |doi= 10.1006/mcne.1999.0741
*cite journal | author=Clark JA, Mezey E, Lam AS, Bonner TI |title=Distribution of the GABA(B) receptor subunit gb2 in rat CNS. |journal=Brain Res. |volume=860 |issue= 1-2 |pages= 41–52 |year= 2000 |pmid= 10727622 |doi=
*cite journal | author=Sullivan R, Chateauneuf A, Coulombe N, "et al." |title=Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor. |journal=J. Pharmacol. Exp. Ther. |volume=293 |issue= 2 |pages= 460–7 |year= 2000 |pmid= 10773016 |doi=
*cite journal | author=White JH, McIllhinney RA, Wise A, "et al." |title=The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 25 |pages= 13967–72 |year= 2001 |pmid= 11087824 |doi= 10.1073/pnas.240452197
*cite journal | author=Kitano J, Kimura K, Yamazaki Y, "et al." |title=Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins. |journal=J. Neurosci. |volume=22 |issue= 4 |pages= 1280–9 |year= 2002 |pmid= 11850456 |doi=
*cite journal | author=Salim K, Fenton T, Bacha J, "et al." |title=Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15482–5 |year= 2002 |pmid= 11854302 |doi= 10.1074/jbc.M201539200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Furtinger S, Pirker S, Czech T, "et al." |title=Increased expression of gamma-aminobutyric acid type B receptors in the hippocampus of patients with temporal lobe epilepsy. |journal=Neurosci. Lett. |volume=352 |issue= 2 |pages= 141–5 |year= 2004 |pmid= 14625043 |doi=
*cite journal | author=Waldvogel HJ, Billinton A, White JH, "et al." |title=Comparative cellular distribution of GABAA and GABAB receptors in the human basal ganglia: immunohistochemical colocalization of the alpha 1 subunit of the GABAA receptor, and the GABABR1 and GABABR2 receptor subunits. |journal=J. Comp. Neurol. |volume=470 |issue= 4 |pages= 339–56 |year= 2004 |pmid= 14961561 |doi= 10.1002/cne.20005
*cite journal | author=Balasubramanian S, Teissére JA, Raju DV, Hall RA |title=Hetero-oligomerization between GABAA and GABAB receptors regulates GABAB receptor trafficking. |journal=J. Biol. Chem. |volume=279 |issue= 18 |pages= 18840–50 |year= 2004 |pmid= 14966130 |doi= 10.1074/jbc.M313470200
*cite journal | author=Uezono Y, Kaibara M, Hayashi H, "et al." |title=Characterization of GABAB receptor in the human colon. |journal=J. Pharmacol. Sci. |volume=94 |issue= 2 |pages= 211–3 |year= 2004 |pmid= 14978362 |doi=
*cite journal | author=Humphray SJ, Oliver K, Hunt AR, "et al." |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Hlavackova V, Goudet C, Kniazeff J, "et al." |title=Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR. |journal=EMBO J. |volume=24 |issue= 3 |pages= 499–509 |year= 2005 |pmid= 15660124 |doi= 10.1038/sj.emboj.7600557
*cite journal | author=DeGiorgis JA, Jaffe H, Moreira JE, "et al." |title=Phosphoproteomic analysis of synaptosomes from human cerebral cortex. |journal=J. Proteome Res. |volume=4 |issue= 2 |pages= 306–15 |year= 2005 |pmid= 15822905 |doi= 10.1021/pr0498436
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Osawa Y, Xu D, Sternberg D, "et al." |title=Functional expression of the GABAB receptor in human airway smooth muscle. |journal=Am. J. Physiol. Lung Cell Mol. Physiol. |volume=291 |issue= 5 |pages= L923–31 |year= 2006 |pmid= 16829628 |doi= 10.1152/ajplung.00185.2006

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