Gastrin-releasing peptide receptor

Gastrin-releasing peptide receptor

The gastrin-releasing peptide receptor (GRPR) is a G protein-coupled receptor whose endogenous ligand is gastrin releasing peptide.cite journal | author = Benya RV, Kusui T, Pradhan TK, Battey JF, Jensen RT | title = Expression and characterization of cloned human bombesin receptors | journal = Mol. Pharmacol. | volume = 47 | issue = 1 | pages = 10–20 | year = 1995 | pmid = 7838118 | doi = | issn = | url =]

section_title =
summary_text = Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.cite web | title = Entrez Gene: GRPR gastrin-releasing peptide receptor| url =| accessdate = ]

The transcription factor CREB is a regulator of human GRP-R expression in colon cancer.cite journal | author = Chinnappan D, Qu X, Xiao D, Ratnasari A, Weber HC | title = Human gastrin releasing peptide receptor gene regulation requires transcription factor binding at two distinct cre sites | journal = Am. J. Physiol. Gastrointest. Liver Physiol. | volume = 295| issue = | pages = G153| year = 2008 | month = May | pmid = 18483184 | doi = 10.1152/ajpgi.00036.2008 | url = ]


Further reading

citations =
*cite journal | author=Corjay MH, Dobrzanski DJ, Way JM, "et al." |title=Two distinct bombesin receptor subtypes are expressed and functional in human lung carcinoma cells. |journal=J. Biol. Chem. |volume=266 |issue= 28 |pages= 18771–9 |year= 1991 |pmid= 1655761 |doi=
*cite journal | author=Alitalo T, Francis F, Kere J, "et al." |title=A 6-Mb YAC contig in Xp22.1-p22.2 spanning the DXS69E, XE59, GLRA2, PIGA, GRPR, CALB3, and PHKA2 genes. |journal=Genomics |volume=25 |issue= 3 |pages= 691–700 |year= 1995 |pmid= 7759104 |doi=10.1016/0888-7543(95)80012-B
*cite journal | author=Benya RV, Kusui T, Pradhan TK, "et al." |title=Expression and characterization of cloned human bombesin receptors. |journal=Mol. Pharmacol. |volume=47 |issue= 1 |pages= 10–20 |year= 1995 |pmid= 7838118 |doi=
*cite journal | author=Giladi E, Nagalla SR, Spindel ER |title=Molecular cloning and characterization of receptors for the mammalian bombesin-like peptides. |journal=J. Mol. Neurosci. |volume=4 |issue= 1 |pages= 41–54 |year= 1993 |pmid= 8391296 |doi=10.1007/BF02736689
*cite journal | author=Maslen GL, Boyd Y |title=Comparative mapping of the Grpr locus on the X chromosomes of man and mouse. |journal=Genomics |volume=17 |issue= 1 |pages= 106–9 |year= 1993 |pmid= 8406441 |doi= 10.1006/geno.1993.1290
*cite journal | author=Ishikawa-Brush Y, Powell JF, Bolton P, "et al." |title=Autism and multiple exostoses associated with an X;8 translocation occurring within the GRPR gene and 3' to the SDC2 gene. |journal=Hum. Mol. Genet. |volume=6 |issue= 8 |pages= 1241–50 |year= 1997 |pmid= 9259269 |doi=10.1093/hmg/6.8.1241
*cite journal | author=Heidary G, Hampton LL, Schanen NC, "et al." |title=Exclusion of the gastrin-releasing peptide receptor (GRPR) locus as a candidate gene for Rett syndrome. |journal=Am. J. Med. Genet. |volume=78 |issue= 2 |pages= 173–5 |year= 1998 |pmid= 9674911 |doi=10.1002/(SICI)1096-8628(19980630)78:2<173::AID-AJMG15>3.0.CO;2-K
*cite journal | author=Shriver SP, Bourdeau HA, Gubish CT, "et al." |title=Sex-specific expression of gastrin-releasing peptide receptor: relationship to smoking history and risk of lung cancer. |journal=J. Natl. Cancer Inst. |volume=92 |issue= 1 |pages= 24–33 |year= 2000 |pmid= 10620630 |doi=10.1093/jnci/92.1.24
*cite journal | author=Xiao D, Wang J, Hampton LL, Weber HC |title=The human gastrin-releasing peptide receptor gene structure, its tissue expression and promoter. |journal=Gene |volume=264 |issue= 1 |pages= 95–103 |year= 2001 |pmid= 11245983 |doi=10.1016/S0378-1119(00)00596-5
*cite journal | author=Carroll RE, Matkowskyj K, Saunthararajah Y, "et al." |title=Contribution of gastrin-releasing peptide and its receptor to villus development in the murine and human gastrointestinal tract. |journal=Mech. Dev. |volume=113 |issue= 2 |pages= 121–30 |year= 2002 |pmid= 11960700 |doi=10.1016/S0925-4773(02)00032-1
*cite journal | author=Qu X, Xiao D, Weber HC |title=Human gastrin-releasing peptide receptor mediates sustained CREB phosphorylation and transactivation in HuTu 80 duodenal cancer cells. |journal=FEBS Lett. |volume=527 |issue= 1-3 |pages= 109–13 |year= 2002 |pmid= 12220644 |doi=10.1016/S0014-5793(02)03177-0
*cite journal | author=Xiao D, Qu X, Weber HC |title=GRP receptor-mediated immediate early gene expression and transcription factor Elk-1 activation in prostate cancer cells. |journal=Regul. Pept. |volume=109 |issue= 1-3 |pages= 141–8 |year= 2003 |pmid= 12409226 |doi=10.1016/S0167-0115(02)00197-0
*cite journal | author=Uchida K, Kojima A, Morokawa N, "et al." |title=Expression of progastrin-releasing peptide and gastrin-releasing peptide receptor mRNA transcripts in tumor cells of patients with small cell lung cancer. |journal=J. Cancer Res. Clin. Oncol. |volume=128 |issue= 12 |pages= 633–40 |year= 2003 |pmid= 12474049 |doi= 10.1007/s00432-002-0392-8
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Shumyatsky GP, Tsvetkov E, Malleret G, "et al." |title=Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. |journal=Cell |volume=111 |issue= 6 |pages= 905–18 |year= 2003 |pmid= 12526815 |doi=10.1016/S0092-8674(02)01116-9
*cite journal | author=Glover SC, Tretiakova MS, Carroll RE, Benya RV |title=Increased frequency of gastrin-releasing peptide receptor gene mutations during colon-adenocarcinoma progression. |journal=Mol. Carcinog. |volume=37 |issue= 1 |pages= 5–15 |year= 2003 |pmid= 12720295 |doi= 10.1002/mc.10117
*cite journal | author=Waters CM, MacKinnon AC, Cummings J, "et al." |title=Increased gastrin-releasing peptide (GRP) receptor expression in tumour cells confers sensitivity to [Arg6,D-Trp7,9,NmePhe8] -substance P (6-11)-induced growth inhibition. |journal=Br. J. Cancer |volume=88 |issue= 11 |pages= 1808–16 |year= 2003 |pmid= 12771999 |doi= 10.1038/sj.bjc.6600957
*cite journal | author=Scott N, Millward E, Cartwright EJ, "et al." |title=Gastrin releasing peptide and gastrin releasing peptide receptor expression in gastrointestinal carcinoid tumours. |journal=J. Clin. Pathol. |volume=57 |issue= 2 |pages= 189–92 |year= 2004 |pmid= 14747448 |doi=10.1136/jcp.2003.10660
*cite journal | author=Chen PW, Kroog GS |title=Alterations in receptor expression or agonist concentration change the pathways gastrin-releasing peptide receptor uses to regulate extracellular signal-regulated kinase. |journal=Mol. Pharmacol. |volume=66 |issue= 6 |pages= 1625–34 |year= 2005 |pmid= 15361544 |doi= 10.1124/mol.104.001206
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

External links

* [ IUPHAR GPCR Database - BB2 receptor]

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