Bombesin-like receptor 3

The bombesin-like receptor 3 (BRS-3) is a G protein-coupled receptor.cite journal | author = Fathi Z, Corjay MH, Shapira H, Wada E, Benya R, Jensen R, Viallet J, Sausville EA, Battey JF | title = BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells | journal = J. Biol. Chem. | volume = 268 | issue = 8 | pages = 5979–84 | year = 1993 | pmid = 8383682 | doi = | issn = | url = http://www.jbc.org/cgi/content/abstract/268/8/5979] As no endogenous ligand has been identified for BRS-3, it is classified as an orphan receptor.

PBB_Summary
section_title =
summary_text = Mammalian bombesin-like peptides (see MIM 137260) are widely distributed in the central nervous system as well as in the gastrointestinal tract, where they modulate smooth-muscle contraction, exocrine and endocrine processes, metabolism, and behavior. They bind to G protein-coupled receptors on the cell surface to elicit their effects. Bombesin-like peptide receptors include gastrin-releasing peptide receptor (MIM 305670), neuromedin B receptor (MIM 162341), and bombesin-like receptor-3 (BRS3) (Ohki-Hamazaki et al., 1997). [supplied by OMIM] cite web | title = Entrez Gene: BRS3 bombesin-like receptor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=680| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Gorbulev V, Akhundova A, Grzeschik KH, Fahrenholz F |title=Organization and chromosomal localization of the gene for the human bombesin receptor subtype expressed in pregnant uterus. |journal=FEBS Lett. |volume=340 |issue= 3 |pages= 260–4 |year= 1994 |pmid= 8131855 |doi=
*cite journal | author=Fathi Z, Corjay MH, Shapira H, "et al." |title=BRS-3: a novel bombesin receptor subtype selectively expressed in testis and lung carcinoma cells. |journal=J. Biol. Chem. |volume=268 |issue= 8 |pages= 5979–84 |year= 1993 |pmid= 8383682 |doi=
*cite journal | author=Kane MA, Toi-Scott M, Johnson GL, "et al." |title=Bombesin-like peptide receptors in human bronchial epithelial cells. |journal=Peptides |volume=17 |issue= 1 |pages= 111–8 |year= 1996 |pmid= 8822519 |doi=
*cite journal | author=Ohki-Hamazaki H, Watase K, Yamamoto K, "et al." |title=Mice lacking bombesin receptor subtype-3 develop metabolic defects and obesity. |journal=Nature |volume=390 |issue= 6656 |pages= 165–9 |year= 1997 |pmid= 9367152 |doi= 10.1038/36568
*cite journal | author=Ryan RR, Weber HC, Hou W, "et al." |title=Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3. |journal=J. Biol. Chem. |volume=273 |issue= 22 |pages= 13613–24 |year= 1998 |pmid= 9593699 |doi=
*cite journal | author=Liu J, Lao ZJ, Zhang J, "et al." |title=Molecular basis of the pharmacological difference between rat and human bombesin receptor subtype-3 (BRS-3). |journal=Biochemistry |volume=41 |issue= 28 |pages= 8954–60 |year= 2002 |pmid= 12102638 |doi=
*cite journal | author=Ross MT, Grafham DV, Coffey AJ, "et al." |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440
*cite journal | author=Hou X, Wei L, Harada A, Tatamoto K |title=Activation of bombesin receptor subtype-3 stimulates adhesion of lung cancer cells. |journal=Lung Cancer |volume=54 |issue= 2 |pages= 143–8 |year= 2007 |pmid= 16979789 |doi= 10.1016/j.lungcan.2006.08.005
*cite journal | author=Tan YR, Qin XQ, Xiang Y, "et al." |title=PPARalpha and AP-2alpha regulate bombesin receptor subtype 3 expression in ozone-stressed bronchial epithelial cells. |journal=Biochem. J. |volume=405 |issue= 1 |pages= 131–7 |year= 2007 |pmid= 17355223 |doi= 10.1042/BJ20061754

External links

* [http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2958 IUPHAR GPCR Database - BB₃ receptor]
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