Corticotropin releasing hormone receptor 2

Corticotropin releasing hormone receptor 2
Identifiers
Symbols	CRHR2; CRF2; CRFR2
External IDs	OMIM: 602034 MGI: 894312 HomoloGene: 55612 GeneCards: CRHR2 Gene
Gene Ontology Molecular function • protein binding • corticotrophin-releasing factor receptor activity Cellular component • plasma membrane • plasma membrane • integral to plasma membrane Biological process • G-protein signaling, coupled to cAMP nucleotide second messenger Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	1395	12922
Ensembl	ENSG00000106113	ENSMUSG00000003476
UniProt	Q13324	Q3UQP0
RefSeq (mRNA)	NM_001202475.1	NM_009953.3
RefSeq (protein)	NP_001189404.1	NP_034083.2
Location (UCSC)	Chr 7: 30.69 – 30.74 Mb	Chr 6: 55.04 – 55.08 Mb
PubMed search	[1]	[2]

Corticotropin releasing hormone receptor 2 (CRHR2) is a human protein, also known as CRF₂, with CRF₂ now being the IUPHAR-recommended name.^[1]

See also

• Corticotropin releasing hormone receptor

References

1. ^ "Entrez Gene: CRHR2 corticotropin releasing hormone receptor 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1395. 

Further reading

• Perrin MH, Donaldson CJ, Chen R, et al. (1994). "Cloning and functional expression of a rat brain corticotropin releasing factor (CRF) receptor.". Endocrinology 133 (6): 3058–61. doi:10.1210/en.133.6.3058. PMID 8243338. 
• Liaw CW, Lovenberg TW, Barry G, et al. (1996). "Cloning and characterization of the human corticotropin-releasing factor-2 receptor complementary deoxyribonucleic acid.". Endocrinology 137 (1): 72–7. doi:10.1210/en.137.1.72. PMID 8536644. 
• Donaldson CJ, Sutton SW, Perrin MH, et al. (1996). "Cloning and characterization of human urocortin.". Endocrinology 137 (5): 2167–70. doi:10.1210/en.137.5.2167. PMID 8612563. 
• Meyer AH, Ullmer C, Schmuck K, et al. (1997). "Localization of the human CRF2 receptor to 7p21-p15 by radiation hybrid mapping and FISH analysis.". Genomics 40 (1): 189–90. doi:10.1006/geno.1996.4521. PMID 9070940. 
• Valdenaire O, Giller T, Breu V, et al. (1997). "A new functional isoform of the human CRF2 receptor for corticotropin-releasing factor.". Biochim. Biophys. Acta 1352 (2): 129–32. PMID 9199241. 
• Gottowik J, Goetschy V, Henriot S, et al. (1998). "Labelling of CRF1 and CRF2 receptors using the novel radioligand, [3H]-urocortin.". Neuropharmacology 36 (10): 1439–46. doi:10.1016/S0028-3908(97)00098-1. PMID 9423932. 
• Kostich WA, Chen A, Sperle K, Largent BL (1998). "Molecular identification and analysis of a novel human corticotropin-releasing factor (CRF) receptor: the CRF2gamma receptor.". Mol. Endocrinol. 12 (8): 1077–85. doi:10.1210/me.12.8.1077. PMID 9717834. 
• Willenberg HS, Bornstein SR, Hiroi N, et al. (2000). "Effects of a novel corticotropin-releasing-hormone receptor type I antagonist on human adrenal function.". Mol. Psychiatry 5 (2): 137–41. doi:10.1038/sj.mp.4000720. PMID 10822340. 
• Reyes TM, Lewis K, Perrin MH, et al. (2001). "Urocortin II: a member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors.". Proc. Natl. Acad. Sci. U.S.A. 98 (5): 2843–8. doi:10.1073/pnas.051626398. PMC 30227. PMID 11226328. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=30227. 
• Hsu SY, Hsueh AJ (2001). "Human stresscopin and stresscopin-related peptide are selective ligands for the type 2 corticotropin-releasing hormone receptor.". Nat. Med. 7 (5): 605–11. doi:10.1038/87936. PMID 11329063. 
• Lewis K, Li C, Perrin MH, et al. (2001). "Identification of urocortin III, an additional member of the corticotropin-releasing factor (CRF) family with high affinity for the CRF2 receptor.". Proc. Natl. Acad. Sci. U.S.A. 98 (13): 7570–5. doi:10.1073/pnas.121165198. PMC 34709. PMID 11416224. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=34709. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961. 
• Wetzka B, Sehringer B, Schäfer WR, et al. (2004). "Expression patterns of CRH, CRH receptors, and CRH binding protein in human gestational tissue at term.". Exp. Clin. Endocrinol. Diabetes 111 (3): 154–61. doi:10.1055/s-2003-39778. PMID 12784189. 
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
• Karteris E, Hillhouse EW, Grammatopoulos D (2004). "Urocortin II is expressed in human pregnant myometrial cells and regulates myosin light chain phosphorylation: potential role of the type-2 corticotropin-releasing hormone receptor in the control of myometrial contractility.". Endocrinology 145 (2): 890–900. doi:10.1210/en.2003-1210. PMID 14592950. 
• Seres J, Bornstein SR, Seres P, et al. (2004). "Corticotropin-releasing hormone system in human adipose tissue.". J. Clin. Endocrinol. Metab. 89 (2): 965–70. doi:10.1210/jc.2003-031299. PMID 14764822. 
• Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. 
• Nanda SA, Roseboom PH, Nash GA, et al. (2004). "Characterization of the human corticotropin-releasing factor2(a) receptor promoter: regulation by glucocorticoids and the cyclic adenosine 5'-monophosphate pathway.". Endocrinology 145 (12): 5605–15. doi:10.1210/en.2004-0907. PMID 15331578. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 

External links

• "Corticotropin-releasing Factor Receptors: CRF₂". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2919. 
• MeSH Corticotropin-releasing+hormone+receptors

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.v · United States National Library of Medicine, which is in the public domain. Wikimedia Foundation. 2010. Игры ⚽ Поможем написать реферат Youth Anthems for the New Order San Francisco Board of Education Look at other dictionaries: Corticotropin releasing hormone receptor 1 — Rendering based on PDB 3EHS …   Wikipedia Corticotropin-releasing hormone receptor — 1 Identifiers Symbol CRHR1 Alt. symbols CRHR Entrez 1394 …   Wikipedia Corticotropin-releasing hormone — PDB rendering based on 1go9 …   Wikipedia Corticotropin releasing hormone antagonist — A Corticotropin releasing hormone antagonist is a specific type of receptor antagonist which blocks the receptor sites for Corticotropin releasing hormone (also known as Corticotropin releasing factor (CRF)), blocking therefore the consequent… …   Wikipedia Melanin-concentrating hormone receptor 1 — Identifiers Symbols MCHR1; GPR24; MCH1R; MGC32129; SLC1 External IDs …   Wikipedia Melanin-concentrating hormone receptor 2 — Identifiers Symbols MCHR2; GPR145; GPRv17; MCH 2R; MCH R2; MCH2; MCH2R; MCHR 2; SLT External IDs …   Wikipedia Melanin-concentrating hormone receptor — 1 Identifiers Symbol MCHR1 Alt. symbols GPR24 Entrez 2847 …   Wikipedia Secretin receptor family — Pfam box Symbol = 7tm 2 Name = Secretin family of 7 transmembrane receptors width = caption = Pfam= PF00002 InterPro= IPR000832 SMART= PROSITE = PDOC00559 SCOP = 1bl1 TCDB = OPM family = 6 OPM protein = 1fjr PDB= PDB|1bl1 ; 17 30; PDB|1et2 S 184… …   Wikipedia Beta adrenergic receptor kinase-2 — Adrenergic, beta, receptor kinase 2, also known as ADRBK2, is a human gene. PBB Summary section title = summary text = The beta adrenergic receptor kinase specifically phosphorylates the agonist occupied form of the beta adrenergic and related G… …   Wikipedia Melanocortin receptor — Melanocortin receptors are members of the rhodopsin family of 7 transmembrane, G protein coupled receptors. There are five known members of the melanocortin receptor system[1] each with differing specificities for melanocortins:[2][3][4] …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”