Somatostatin receptor 1

Somatostatin receptor 1, also known as SSTR1, is a human gene.cite web | title = Entrez Gene: SSTR1 somatostatin receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6751| accessdate = ]

PBB_Summary
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summary_text = Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. The encoded protein is a member of the superfamily of somatostatin receptors having seven transmembrane segments, and is expressed in highest levels in jejunum and stomach.cite web | title = Entrez Gene: SSTR1 somatostatin receptor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6751| accessdate = ]

ee also

* Somatostatin receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yamada Y, Post SR, Wang K, "et al." |title=Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 1 |pages= 251–5 |year= 1992 |pmid= 1346068 |doi=
*cite journal | author=Fujita T, Yamaji Y, Sato M, "et al." |title=Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines. |journal=Life Sci. |volume=55 |issue= 23 |pages= 1797–806 |year= 1994 |pmid= 7968260 |doi=
*cite journal | author=Kaupmann K, Bruns C, Hoyer D, "et al." |title=Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain. |journal=FEBS Lett. |volume=331 |issue= 1-2 |pages= 53–9 |year= 1993 |pmid= 8405411 |doi=
*cite journal | author=Yamada Y, Stoffel M, Espinosa R, "et al." |title=Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. |journal=Genomics |volume=15 |issue= 2 |pages= 449–52 |year= 1993 |pmid= 8449518 |doi= 10.1006/geno.1993.1088
*cite journal | author=Le Romancer M, Cherifi Y, Levasseur S, "et al." |title=Messenger RNA expression of somatostatin receptor subtypes in human and rat gastric mucosae. |journal=Life Sci. |volume=58 |issue= 13 |pages= 1091–8 |year= 1996 |pmid= 8622562 |doi=
*cite journal | author=Fukusumi S, Kitada C, Takekawa S, "et al." |title=Identification and characterization of a novel human cortistatin-like peptide. |journal=Biochem. Biophys. Res. Commun. |volume=232 |issue= 1 |pages= 157–63 |year= 1997 |pmid= 9125122 |doi= 10.1006/bbrc.1997.6252
*cite journal | author=de Lecea L, Ruiz-Lozano P, Danielson PE, "et al." |title=Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin. |journal=Genomics |volume=42 |issue= 3 |pages= 499–506 |year= 1997 |pmid= 9205124 |doi= 10.1006/geno.1997.4763
*cite journal | author=Jaïs P, Terris B, Ruszniewski P, "et al." |title=Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours. |journal=Eur. J. Clin. Invest. |volume=27 |issue= 8 |pages= 639–44 |year= 1997 |pmid= 9279525 |doi=
*cite journal | author=Ferone D, van Hagen PM, van Koetsveld PM, "et al." |title=In vitro characterization of somatostatin receptors in the human thymus and effects of somatostatin and octreotide on cultured thymic epithelial cells. |journal=Endocrinology |volume=140 |issue= 1 |pages= 373–80 |year= 1999 |pmid= 9886848 |doi=
*cite journal | author=Kumar U, Sasi R, Suresh S, "et al." |title=Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis. |journal=Diabetes |volume=48 |issue= 1 |pages= 77–85 |year= 1999 |pmid= 9892225 |doi=
*cite journal | author=Rocheville M, Lange DC, Kumar U, "et al." |title=Subtypes of the somatostatin receptor assemble as functional homo- and heterodimers. |journal=J. Biol. Chem. |volume=275 |issue= 11 |pages= 7862–9 |year= 2000 |pmid= 10713101 |doi=
*cite journal | author=Schwärzler A, Kreienkamp HJ, Richter D |title=Interaction of the somatostatin receptor subtype 1 with the human homolog of the Shk1 kinase-binding protein from yeast. |journal=J. Biol. Chem. |volume=275 |issue= 13 |pages= 9557–62 |year= 2000 |pmid= 10734105 |doi=
*cite journal | author=Zatelli MC, Tagliati F, Taylor JE, "et al." |title=Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 5 |pages= 2161–9 |year= 2001 |pmid= 11344221 |doi=
*cite journal | author=Klisovic DD, O'Dorisio MS, Katz SE, "et al." |title=Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study. |journal=Invest. Ophthalmol. Vis. Sci. |volume=42 |issue= 10 |pages= 2193–201 |year= 2001 |pmid= 11527930 |doi=
*cite journal | author=Pasquali D, Notaro A, Esposito D, "et al." |title= [Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy] |journal=Minerva Endocrinol. |volume=26 |issue= 3 |pages= 175–9 |year= 2002 |pmid= 11753241 |doi=
*cite journal | author=Papotti M, Bongiovanni M, Volante M, "et al." |title=Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis. |journal=Virchows Arch. |volume=440 |issue= 5 |pages= 461–75 |year= 2002 |pmid= 12021920 |doi= 10.1007/s00428-002-0609-x
*cite journal | author=Zatelli MC, Tagliati F, Piccin D, "et al." |title=Somatostatin receptor subtype 1-selective activation reduces cell growth and calcitonin secretion in a human medullary thyroid carcinoma cell line. |journal=Biochem. Biophys. Res. Commun. |volume=297 |issue= 4 |pages= 828–34 |year= 2002 |pmid= 12359227 |doi=
*cite journal | author=Ferone D, Pivonello R, Van Hagen PM, "et al." |title=Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes. |journal=Am. J. Physiol. Endocrinol. Metab. |volume=283 |issue= 5 |pages= E1056–66 |year= 2002 |pmid= 12376335 |doi= 10.1152/ajpendo.00205.2001
*cite journal | author=Pasquali D, Notaro A, Bonavolonta' G, "et al." |title=Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 11 |pages= 5125–9 |year= 2002 |pmid= 12414882 |doi=
*cite journal | author=Dizeyi N, Konrad L, Bjartell A, "et al." |title=Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines. |journal=Urol. Oncol. |volume=7 |issue= 3 |pages= 91–8 |year= 2002 |pmid= 12474541 |doi=

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1298 IUPHAR Receptor Database - Somatostatin Receptors]
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