Somatostatin receptor 2

Somatostatin receptor 2, also known as SSTR2, is a human gene.

PBB_Summary
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summary_text = Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney.cite web | title = Entrez Gene: SSTR2 somatostatin receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6752| accessdate = ]

ee also

* Somatostatin receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yamada Y, Post SR, Wang K, "et al." |title=Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 1 |pages= 251–5 |year= 1992 |pmid= 1346068 |doi=
*cite journal | author=Reubi JC, Waser B, Schaer JC, Markwalder R |title=Somatostatin receptors in human prostate and prostate cancer. |journal=J. Clin. Endocrinol. Metab. |volume=80 |issue= 9 |pages= 2806–14 |year= 1995 |pmid= 7673428 |doi=
*cite journal | author=Kagimoto S, Yamada Y, Kubota A, "et al." |title=Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein. |journal=Biochem. Biophys. Res. Commun. |volume=202 |issue= 2 |pages= 1188–95 |year= 1994 |pmid= 7914078 |doi= 10.1006/bbrc.1994.2054
*cite journal | author=Fujita T, Yamaji Y, Sato M, "et al." |title=Gene expression of somatostatin receptor subtypes, SSTR1 and SSTR2, in human lung cancer cell lines. |journal=Life Sci. |volume=55 |issue= 23 |pages= 1797–806 |year= 1994 |pmid= 7968260 |doi=
*cite journal | author=Patel YC, Greenwood M, Kent G, "et al." |title=Multiple gene transcripts of the somatostatin receptor SSTR2: tissue selective distribution and cAMP regulation. |journal=Biochem. Biophys. Res. Commun. |volume=192 |issue= 1 |pages= 288–94 |year= 1993 |pmid= 8386508 |doi= 10.1006/bbrc.1993.1412
*cite journal | author=Yamada Y, Stoffel M, Espinosa R, "et al." |title=Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. |journal=Genomics |volume=15 |issue= 2 |pages= 449–52 |year= 1993 |pmid= 8449518 |doi= 10.1006/geno.1993.1088
*cite journal | author=Fukusumi S, Kitada C, Takekawa S, "et al." |title=Identification and characterization of a novel human cortistatin-like peptide. |journal=Biochem. Biophys. Res. Commun. |volume=232 |issue= 1 |pages= 157–63 |year= 1997 |pmid= 9125122 |doi= 10.1006/bbrc.1997.6252
*cite journal | author=Jaïs P, Terris B, Ruszniewski P, "et al." |title=Somatostatin receptor subtype gene expression in human endocrine gastroentero-pancreatic tumours. |journal=Eur. J. Clin. Invest. |volume=27 |issue= 8 |pages= 639–44 |year= 1997 |pmid= 9279525 |doi=
*cite journal | author=Lopez F, Estève JP, Buscail L, "et al." |title=The tyrosine phosphatase SHP-1 associates with the sst2 somatostatin receptor and is an essential component of sst2-mediated inhibitory growth signaling. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24448–54 |year= 1997 |pmid= 9305905 |doi=
*cite journal | author=Tsutsumi A, Takano H, Ichikawa K, "et al." |title=Expression of somatostatin receptor subtype 2 mRNA in human lymphoid cells. |journal=Cell. Immunol. |volume=181 |issue= 1 |pages= 44–9 |year= 1997 |pmid= 9344495 |doi= 10.1006/cimm.1997.1193
*cite journal | author=Sharma K, Patel YC, Srikant CB |title=C-terminal region of human somatostatin receptor 5 is required for induction of Rb and G1 cell cycle arrest. |journal=Mol. Endocrinol. |volume=13 |issue= 1 |pages= 82–90 |year= 1999 |pmid= 9892014 |doi=
*cite journal | author=Kumar U, Sasi R, Suresh S, "et al." |title=Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysis. |journal=Diabetes |volume=48 |issue= 1 |pages= 77–85 |year= 1999 |pmid= 9892225 |doi=
*cite journal | author=Zitzer H, Richter D, Kreienkamp HJ |title=Agonist-dependent interaction of the rat somatostatin receptor subtype 2 with cortactin-binding protein 1. |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18153–6 |year= 1999 |pmid= 10373412 |doi=
*cite journal | author=Zitzer H, Hönck HH, Bächner D, "et al." |title=Somatostatin receptor interacting protein defines a novel family of multidomain proteins present in human and rodent brain. |journal=J. Biol. Chem. |volume=274 |issue= 46 |pages= 32997–3001 |year= 2000 |pmid= 10551867 |doi=
*cite journal | author=Petersenn S, Rasch AC, Presch S, "et al." |title=Genomic structure and transcriptional regulation of the human somatostatin receptor type 2. |journal=Mol. Cell. Endocrinol. |volume=157 |issue= 1-2 |pages= 75–85 |year= 2000 |pmid= 10619399 |doi=
*cite journal | author=Kreienkamp HJ, Zitzer H, Richter D |title=Identification of proteins interacting with the rat somatostatin receptor subtype 2. |journal=J. Physiol. Paris |volume=94 |issue= 3-4 |pages= 193–8 |year= 2001 |pmid= 11087996 |doi=
*cite journal | author=Ho MK, Yung LY, Chan JS, "et al." |title=Galpha(14) links a variety of G(i)- and G(s)-coupled receptors to the stimulation of phospholipase C. |journal=Br. J. Pharmacol. |volume=132 |issue= 7 |pages= 1431–40 |year= 2001 |pmid= 11264236 |doi= 10.1038/sj.bjp.0703933
*cite journal | author=Zatelli MC, Tagliati F, Taylor JE, "et al." |title=Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 5 |pages= 2161–9 |year= 2001 |pmid= 11344221 |doi=
*cite journal | author=Talme T, Ivanoff J, Hägglund M, "et al." |title=Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3. |journal=Clin. Exp. Immunol. |volume=125 |issue= 1 |pages= 71–9 |year= 2001 |pmid= 11472428 |doi=
*cite journal | author=Klisovic DD, O'Dorisio MS, Katz SE, "et al." |title=Somatostatin receptor gene expression in human ocular tissues: RT-PCR and immunohistochemical study. |journal=Invest. Ophthalmol. Vis. Sci. |volume=42 |issue= 10 |pages= 2193–201 |year= 2001 |pmid= 11527930 |doi=

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1298 IUPHAR Receptor Database - Somatostatin Receptors]
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