Somatostatin receptor 3

Somatostatin receptor 3, also known as SSTR3, is a human gene.cite web | title = Entrez Gene: SSTR3 somatostatin receptor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6753| accessdate = ]

PBB_Summary
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summary_text = Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biological effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR3 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in brain and pancreatic islets. SSTR3 is functionally coupled to adenylyl cyclase.cite web | title = Entrez Gene: SSTR3 somatostatin receptor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6753| accessdate = ]

ee also

* Somatostatin receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yamada Y, Reisine T, Law SF, "et al." |title=Somatostatin receptors, an expanding gene family: cloning and functional characterization of human SSTR3, a protein coupled to adenylyl cyclase. |journal=Mol. Endocrinol. |volume=6 |issue= 12 |pages= 2136–42 |year= 1993 |pmid= 1337145 |doi=
*cite journal | author=Yamada Y, Post SR, Wang K, "et al." |title=Cloning and functional characterization of a family of human and mouse somatostatin receptors expressed in brain, gastrointestinal tract, and kidney. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 1 |pages= 251–5 |year= 1992 |pmid= 1346068 |doi=
*cite journal | author=Corness JD, Demchyshyn LL, Seeman P, "et al." |title=A human somatostatin receptor (SSTR3), located on chromosome 22, displays preferential affinity for somatostatin-14 like peptides. |journal=FEBS Lett. |volume=321 |issue= 2-3 |pages= 279–84 |year= 1993 |pmid= 8097479 |doi=
*cite journal | author=Law SF, Zaina S, Sweet R, "et al." |title=Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation. |journal=Mol. Pharmacol. |volume=45 |issue= 4 |pages= 587–90 |year= 1994 |pmid= 8183236 |doi=
*cite journal | author=Kaupmann K, Bruns C, Hoyer D, "et al." |title=Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain. |journal=FEBS Lett. |volume=331 |issue= 1-2 |pages= 53–9 |year= 1993 |pmid= 8405411 |doi=
*cite journal | author=Yamada Y, Stoffel M, Espinosa R, "et al." |title=Human somatostatin receptor genes: localization to human chromosomes 14, 17, and 22 and identification of simple tandem repeat polymorphisms. |journal=Genomics |volume=15 |issue= 2 |pages= 449–52 |year= 1993 |pmid= 8449518 |doi= 10.1006/geno.1993.1088
*cite journal | author=Sharma K, Patel YC, Srikant CB |title=Subtype-selective induction of wild-type p53 and apoptosis, but not cell cycle arrest, by human somatostatin receptor 3. |journal=Mol. Endocrinol. |volume=10 |issue= 12 |pages= 1688–96 |year= 1997 |pmid= 8961277 |doi=
*cite journal | author=Fukusumi S, Kitada C, Takekawa S, "et al." |title=Identification and characterization of a novel human cortistatin-like peptide. |journal=Biochem. Biophys. Res. Commun. |volume=232 |issue= 1 |pages= 157–63 |year= 1997 |pmid= 9125122 |doi= 10.1006/bbrc.1997.6252
*cite journal | author=Ain KB, Taylor KD, Tofiq S, Venkataraman G |title=Somatostatin receptor subtype expression in human thyroid and thyroid carcinoma cell lines. |journal=J. Clin. Endocrinol. Metab. |volume=82 |issue= 6 |pages= 1857–62 |year= 1997 |pmid= 9177396 |doi=
*cite journal | author=de Lecea L, Ruiz-Lozano P, Danielson PE, "et al." |title=Cloning, mRNA expression, and chromosomal mapping of mouse and human preprocortistatin. |journal=Genomics |volume=42 |issue= 3 |pages= 499–506 |year= 1997 |pmid= 9205124 |doi= 10.1006/geno.1997.4763
*cite journal | author=Roth A, Kreienkamp HJ, Meyerhof W, Richter D |title=Phosphorylation of four amino acid residues in the carboxyl terminus of the rat somatostatin receptor subtype 3 is crucial for its desensitization and internalization. |journal=J. Biol. Chem. |volume=272 |issue= 38 |pages= 23769–74 |year= 1997 |pmid= 9295322 |doi=
*cite journal | author=Dunham I, Shimizu N, Roe BA, "et al." |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031
*cite journal | author=Zatelli MC, Tagliati F, Taylor JE, "et al." |title=Somatostatin receptor subtypes 2 and 5 differentially affect proliferation in vitro of the human medullary thyroid carcinoma cell line tt. |journal=J. Clin. Endocrinol. Metab. |volume=86 |issue= 5 |pages= 2161–9 |year= 2001 |pmid= 11344221 |doi=
*cite journal | author=Talme T, Ivanoff J, Hägglund M, "et al." |title=Somatostatin receptor (SSTR) expression and function in normal and leukaemic T-cells. Evidence for selective effects on adhesion to extracellular matrix components via SSTR2 and/or 3. |journal=Clin. Exp. Immunol. |volume=125 |issue= 1 |pages= 71–9 |year= 2001 |pmid= 11472428 |doi=
*cite journal | author=Pasquali D, Notaro A, Esposito D, "et al." |title= [Somatostatin receptor genes expression and effects of octreotide on orbital fibroblasts from Graves' ophthalmopathy] |journal=Minerva Endocrinol. |volume=26 |issue= 3 |pages= 175–9 |year= 2002 |pmid= 11753241 |doi=
*cite journal | author=Papotti M, Bongiovanni M, Volante M, "et al." |title=Expression of somatostatin receptor types 1-5 in 81 cases of gastrointestinal and pancreatic endocrine tumors. A correlative immunohistochemical and reverse-transcriptase polymerase chain reaction analysis. |journal=Virchows Arch. |volume=440 |issue= 5 |pages= 461–75 |year= 2002 |pmid= 12021920 |doi= 10.1007/s00428-002-0609-x
*cite journal | author=Ferone D, Pivonello R, Van Hagen PM, "et al." |title=Quantitative and functional expression of somatostatin receptor subtypes in human thymocytes. |journal=Am. J. Physiol. Endocrinol. Metab. |volume=283 |issue= 5 |pages= E1056–66 |year= 2002 |pmid= 12376335 |doi= 10.1152/ajpendo.00205.2001
*cite journal | author=Pasquali D, Notaro A, Bonavolonta' G, "et al." |title=Somatostatin receptor genes are expressed in lymphocytes from retroorbital tissues in Graves' disease. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 11 |pages= 5125–9 |year= 2002 |pmid= 12414882 |doi=
*cite journal | author=Dizeyi N, Konrad L, Bjartell A, "et al." |title=Localization and mRNA expression of somatostatin receptor subtypes in human prostatic tissue and prostate cancer cell lines. |journal=Urol. Oncol. |volume=7 |issue= 3 |pages= 91–8 |year= 2002 |pmid= 12474541 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1298 IUPHAR Receptor Database - Somatostatin Receptors]
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