CP-154,526

CP-154,526

chembox new
ImageFile = CP154526.svg
ImageSize = 200px
IUPACName = N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)pyrrolo [3,2-e] pyrimidin-4-amine
OtherNames =
Section1 = Chembox Identifiers
CASNo=157286-86-7
PubChem=5311055
SMILES=CCCCN(CC)C1=NC(=NC2=C1C(=CN2C3=C(C=C(C=C3C)C)C)C)C
Section2 = Chembox Properties
Formula=C23H32N4
MolarMass=364.52698
Appearance=
Density=
MeltingPt=
BoilingPt=
Solubility=
Section3 = Chembox Hazards
MainHazards=
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CP-154,526 is a potent and selective antagonist of the corticotropin releasing hormone receptor 1 developed by Pfizer.cite journal | author = Schulz DW, Mansbach RS, Sprouse J, Braselton JP, Collins J, Corman M, Dunaiskis A, Faraci S, Schmidt AW, Seeger T, Seymour P, Tingley FD 3rd, Winston EN, Chen YL, Heym J | title = CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 19 | pages = 10477–82 | year = 1996 | month = September | pmid = 8816826 | pmc = 38410 | url = http://www.pnas.org/content/93/19/10477.abstract | issn = ]

CP-154,526 is under investigation for the potential treatment of alcoholism.cite web | url = http://www.sciencedaily.com/releases/2008/07/080730175518.htm | title = Drug Has Potential To Prevent Alcoholics From Relapsing | author = | authorlink = | coauthors = | date = 2008-08-02 | format = | work = Science News | publisher = ScienceDaily | pages = | language = | archiveurl = | archivedate = | quote = | accessdate = 2008-08-09] cite journal | author = Pastor R, McKinnon CS, Scibelli AC, Burkhart-Kasch S, Reed C, Ryabinin AE, Coste SC, Stenzel-Poore MP, Phillips TJ | title = Corticotropin-releasing factor-1 receptor involvement in behavioral neuroadaptation to ethanol: a urocortin1-independent mechanism | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 105 | issue = 26 | pages = 9070–5 | year = 2008 | month = July | pmid = 18591672 | doi = 10.1073/pnas.0710181105 | url = | issn = ]

ee also

* Antalarmin
* Pexacerfont
* Corticotropin releasing hormone antagonist

References

External links

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