5-HT1B receptor

5-hydroxytryptamine (serotonin) receptor 1B, also known as HTR1B, is a human 5-HT receptor, but also denotes the gene encoding it.cite web | title = Entrez Gene: HTR1B 5-hydroxytryptamine (serotonin) receptor 1B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3351| accessdate = ]

Tissue distribution and function

5-HT_1B acts on the CNS, where it induces presynaptic inhibition and behavioural effects. It also has vascular effects, such as pulmonary vasoconstriction.

5-HT_1B receptors are present in many parts of the human brain. The highest concentrations are found in the basal ganglia, striatum and the frontal cortex. The function of the receptor differs between the areas: in the frontal lobes it is believed to act as an terminal receptor, inhibiting the release of dopamine. In the striatum and the basal ganglia, the 5-HT_1B receptor is thought to act as an autoreceptor, inhibiting the release of serotonin.

Knockout mice lacking the 5-HT_1B gene has shown an increase of aggression and a higher preference for alcohol.cite journal | author = Hoyer D, Hannon JP, Martin GR | title = Molecular, pharmacological and functional diversity of 5-HT receptors | journal = Pharmacol. Biochem. Behav. | volume = 71 | issue = 4 | pages = 533–54 | year = 2002 | pmid = 11888546 | doi = 10.1016/S0091-3057(01)00746-8 | issn = ]

Ligands

Genetics

In humans the protein is coded by the gene "HTR1B".

A genetic variant in the promotor region, "A-161T", has been examined with respect to personality traits and showed no major effect. [Cite journal
author = Shih-Jen Tsai, Ying-Chieh Wang, Jen-Yeu Chen & Chen-Jee Hong
title = Allelic variants of the tryptophan hydroxylase (A218C) and serotonin 1B receptor (A-161T) and personality traits
journal = Neuropsychobiology
volume = 48
issue = 2
pages = 68–61
year = 2003
month =
doi = 10.1159/000072879
pmid = 14504413]

ee also

* 5-HT₁ receptor
* 5-HT receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Olivier B, van Oorschot R |title=5-HT1B receptors and aggression: a review. |journal=Eur. J. Pharmacol. |volume=526 |issue= 1-3 |pages= 207–17 |year= 2006 |pmid= 16310769 |doi= 10.1016/j.ejphar.2005.09.066
*cite journal | author=Hamblin MW, Metcalf MA, McGuffin RW, Karpells S |title=Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity. |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 2 |pages= 752–9 |year= 1992 |pmid= 1315531 |doi=
*cite journal | author=Veldman SA, Bienkowski MJ |title=Cloning and pharmacological characterization of a novel human 5-hydroxytryptamine1D receptor subtype. |journal=Mol. Pharmacol. |volume=42 |issue= 3 |pages= 439–44 |year= 1992 |pmid= 1328844 |doi=
*cite journal | author=Jin H, Oksenberg D, Ashkenazi A, "et al." |title=Characterization of the human 5-hydroxytryptamine1B receptor. |journal=J. Biol. Chem. |volume=267 |issue= 9 |pages= 5735–8 |year= 1992 |pmid= 1348246 |doi=
*cite journal | author=Demchyshyn L, Sunahara RK, Miller K, "et al." |title=A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 12 |pages= 5522–6 |year= 1992 |pmid= 1351684 |doi=
*cite journal | author=Levy FO, Gudermann T, Perez-Reyes E, "et al." |title=Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype. |journal=J. Biol. Chem. |volume=267 |issue= 11 |pages= 7553–62 |year= 1992 |pmid= 1559993 |doi=
*cite journal | author=Weinshank RL, Zgombick JM, Macchi MJ, "et al." |title=Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 8 |pages= 3630–4 |year= 1992 |pmid= 1565658 |doi=
*cite journal | author=Mochizuki D, Yuyama Y, Tsujita R, "et al." |title=Cloning and expression of the human 5-HT1B-type receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=185 |issue= 2 |pages= 517–23 |year= 1992 |pmid= 1610347 |doi=
*cite journal | author=Nöthen MM, Erdmann J, Shimron-Abarbanell D, Propping P |title=Identification of genetic variation in the human serotonin 1D beta receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=205 |issue= 2 |pages= 1194–200 |year= 1995 |pmid= 7802650 |doi=
*cite journal | author=Ng GY, George SR, Zastawny RL, "et al." |title=Human serotonin1B receptor expression in Sf9 cells: phosphorylation, palmitoylation, and adenylyl cyclase inhibition. |journal=Biochemistry |volume=32 |issue= 43 |pages= 11727–33 |year= 1993 |pmid= 8218242 |doi=
*cite journal | author=Bouchelet I, Cohen Z, Case B, "et al." |title=Differential expression of sumatriptan-sensitive 5-hydroxytryptamine receptors in human trigeminal ganglia and cerebral blood vessels. |journal=Mol. Pharmacol. |volume=50 |issue= 2 |pages= 219–23 |year= 1996 |pmid= 8700126 |doi=
*cite journal | author=Sanders AR, Cao Q, Taylor J, "et al." |title=Genetic diversity of the human serotonin receptor 1B (HTR1B) gene. |journal=Genomics |volume=72 |issue= 1 |pages= 1–14 |year= 2001 |pmid= 11247661 |doi= 10.1006/geno.2000.6411
*cite journal | author=Varnäs K, Hall H, Bonaventure P, Sedvall G |title=Autoradiographic mapping of 5-HT(1B) and 5-HT(1D) receptors in the post mortem human brain using [(3)H] GR 125743. |journal=Brain Res. |volume=915 |issue= 1 |pages= 47–57 |year= 2001 |pmid= 11578619 |doi=
*cite journal | author=Salim K, Fenton T, Bacha J, "et al." |title=Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation. |journal=J. Biol. Chem. |volume=277 |issue= 18 |pages= 15482–5 |year= 2002 |pmid= 11854302 |doi= 10.1074/jbc.M201539200
*cite journal | author=Hasegawa Y, Higuchi S, Matsushita S, Miyaoka H |title=Association of a polymorphism of the serotonin 1B receptor gene and alcohol dependence with inactive aldehyde dehydrogenase-2. |journal=Journal of neural transmission (Vienna, Austria : 1996) |volume=109 |issue= 4 |pages= 513–21 |year= 2002 |pmid= 11956970 |doi= 10.1007/s007020200042
*cite journal | author=Hawi Z, Dring M, Kirley A, "et al." |title=Serotonergic system and attention deficit hyperactivity disorder (ADHD): a potential susceptibility locus at the 5-HT(1B) receptor gene in 273 nuclear families from a multi-centre sample. |journal=Mol. Psychiatry |volume=7 |issue= 7 |pages= 718–25 |year= 2003 |pmid= 12192616 |doi= 10.1038/sj.mp.4001048
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Huang YY, Oquendo MA, Friedman JM, "et al." |title=Substance abuse disorder and major depression are associated with the human 5-HT1B receptor gene (HTR1B) G861C polymorphism. |journal=Neuropsychopharmacology |volume=28 |issue= 1 |pages= 163–9 |year= 2003 |pmid= 12496953 |doi= 10.1038/sj.npp.1300000
*cite journal | author=Quist JF, Barr CL, Schachar R, "et al." |title=The serotonin 5-HT1B receptor gene and attention deficit hyperactivity disorder. |journal=Mol. Psychiatry |volume=8 |issue= 1 |pages= 98–102 |year= 2003 |pmid= 12556913 |doi= 10.1038/sj.mp.4001244
*cite journal | author=Sinha R, Cloninger CR, Parsian A |title=Linkage disequilibrium and haplotype analysis between serotonin receptor 1B gene variations and subtypes of alcoholism. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=121 |issue= 1 |pages= 83–8 |year= 2003 |pmid= 12898580 |doi= 10.1002/ajmg.b.20064

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