LPHN1

Latrophilin 1, also known as LPHN1, is a human gene.cite web | title = Entrez Gene: LPHN1 latrophilin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22859| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the latrophilin subfamily of G-protein coupled receptors (GPCR). Latrophilins may function in both cell adhesion and signal transduction. In experiments with non-human species, endogenous proteolytic cleavage within a cysteine-rich GPS (G-protein-coupled-receptor proteolysis site) domain resulted in two subunits (a large extracellular N-terminal cell adhesion subunit and a subunit with substantial similarity to the secretin/calcitonin family of GPCRs) being non-covalently bound at the cell membrane. Latrophilin-1 has been shown to recruit the neurotoxin from black widow spider venom, alpha-latrotoxin, to the synapse plasma membrane.cite web | title = Entrez Gene: LPHN1 latrophilin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22859| accessdate = ]

ee also

* Latrophilin receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Hayflick JS |title=A family of heptahelical receptors with adhesion-like domains: a marriage between two super families. |journal=J. Recept. Signal Transduct. Res. |volume=20 |issue= 2-3 |pages= 119–31 |year= 2001 |pmid= 10994649 |doi=
*cite journal | author=Südhof TC |title=alpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins. |journal=Annu. Rev. Neurosci. |volume=24 |issue= |pages= 933–62 |year= 2001 |pmid= 11520923 |doi= 10.1146/annurev.neuro.24.1.933
*cite journal | author=Ushkaryov YA, Volynski KE, Ashton AC |title=The multiple actions of black widow spider toxins and their selective use in neurosecretion studies. |journal=Toxicon |volume=43 |issue= 5 |pages= 527–42 |year= 2004 |pmid= 15066411 |doi= 10.1016/j.toxicon.2004.02.008
*cite journal | author=Nagase T, Ishikawa K, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355–64 |year= 1999 |pmid= 10048485 |doi=
*cite journal | author=Kreienkamp HJ, Zitzer H, Gundelfinger ED, "et al." |title=The calcium-independent receptor for alpha-latrotoxin from human and rodent brains interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins. |journal=J. Biol. Chem. |volume=275 |issue= 42 |pages= 32387–90 |year= 2000 |pmid= 10964907 |doi= 10.1074/jbc.C000490200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Brill LM, Salomon AR, Ficarro SB, "et al." |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d
*cite journal | author=Bjarnadóttir TK, Fredriksson R, Höglund PJ, "et al." |title=The human and mouse repertoire of the adhesion family of G-protein-coupled receptors. |journal=Genomics |volume=84 |issue= 1 |pages= 23–33 |year= 2005 |pmid= 15203201 |doi= 10.1016/j.ygeno.2003.12.004
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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