- Histamine receptor
The histamine receptors are a class of
G-protein coupled receptors with histamineas their endogenous ligand.cite journal | author = Hill SJ, Ganellin CR, Timmerman H, Schwartz JC, Shankley NP, Young JM, Schunack W, Levi R, Haas HL | title = International Union of Pharmacology. XIII. Classification of histamine receptors | journal = Pharmacol. Rev. | volume = 49 | issue = 3 | pages = 253–78 | year = 1997 | pmid = 9311023 | doi = | issn = | url = http://pharmrev.aspetjournals.org/cgi/content/abstract/49/3/253 ]
There are several
splice variants of H3 present in various species. Though all of the receptors are 7-transmembrane g protein coupled receptors, H1 and H2 are quite different from H3 and H4 in their activities. H1 causes an increase in phosphoinositol hydrolysis, H2 stimulates gastric acidsecretion, and H3 mediates feedback inhibitionof histamine.
* [http://www.biotrend.com/download/5BT%20Histamine%20Review11_07.pdf Holger Stark: Histamine Receptors, BIOTREND Reviews No. 01, November 2007]
* [http://macromoleculeinsights.com/histaminerec.php The Histamine Receptor]
* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1287 IUPHAR GPCR Database - Histamine Receptors]
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