Histamine receptor

Histamine receptor

The histamine receptors are a class of G-protein coupled receptors with histamine as their endogenous ligand.cite journal | author = Hill SJ, Ganellin CR, Timmerman H, Schwartz JC, Shankley NP, Young JM, Schunack W, Levi R, Haas HL | title = International Union of Pharmacology. XIII. Classification of histamine receptors | journal = Pharmacol. Rev. | volume = 49 | issue = 3 | pages = 253–78 | year = 1997 | pmid = 9311023 | doi = | issn = | url = http://pharmrev.aspetjournals.org/cgi/content/abstract/49/3/253 ]

There are four known histamine receptors:
*H1 receptor
*H2 receptor
*H3 receptor
*H4 receptor


There are several splice variants of H3 present in various species. Though all of the receptors are 7-transmembrane g protein coupled receptors, H1 and H2 are quite different from H3 and H4 in their activities. H1 causes an increase in phosphoinositol hydrolysis, H2 stimulates gastric acid secretion, and H3 mediates feedback inhibition of histamine.


External links

* [http://www.biotrend.com/download/5BT%20Histamine%20Review11_07.pdf Holger Stark: Histamine Receptors, BIOTREND Reviews No. 01, November 2007]
* [http://macromoleculeinsights.com/histaminerec.php The Histamine Receptor]
* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1287 IUPHAR GPCR Database - Histamine Receptors]

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • H2 histamine receptor — noun see H2 receptor …   Useful english dictionary

  • Histamine H3 receptor — Histamine H3 receptors are expressed in the central nervous system and to a lesser extent the peripheral nervous system, where they act as autoreceptors in presynaptic histaminergic neurons, and also control histamine turnover by feedback… …   Wikipedia

  • Histamine H1 receptor — The H1 receptor is a histamine receptor, and thus an important target for clinically important drugs, and is likely one of the most important receptors for modulating mammalian circadian cycles. Histamine H1 receptor are metabotropic G protein… …   Wikipedia

  • Histamine H2 receptor — H2 receptors positively coupled to adenylate cyclase via Gs. It is a potent stimulant of cAMP production. It increases the intracellular Ca2+ concentrations and release Ca2+ from intracellular stores. The drug betazole is an example of a… …   Wikipedia

  • Histamine antagonist — A histamine antagonist, commonly referred to as antihistamine, is a pharmaceutical drug that inhibits action of histamine by blocking it from attaching to histamine receptors. Contents 1 Clinical effects 2 Clinical: H1 and H2 receptor antagonists …   Wikipedia

  • Histamine H4 receptor — protein Name=histamine receptor H4 caption= width= HGNCid=17383 Symbol=HRH4 AltSymbols= EntrezGene=59340 OMIM=606792 RefSeq=NM 021624 UniProt=Q9H3N8 PDB= ECnumber= Chromosome=18 Arm=q Band=11.2 LocusSupplementaryData=The histamine H4 receptor is …   Wikipedia

  • Receptor antagonist — This article is about the biochemistry term. For other uses, see Antagonist (disambiguation). Antagonists will block the binding of an agonist at a receptor molecule, inhibiting the signal produced by a receptor agonist coupling. A receptor… …   Wikipedia

  • Histamine — Chembox new ImageFile=Histamin Histamine.svg ImageSize= ImageFile2=Histamine3d.png ImageSize2=200px IUPACName=2 (3H imidazol 4 yl)ethanamine OtherNames= Section1= Chembox Identifiers CASNo=51 45 6 PubChem=774 ChemSpiderID = 753… …   Wikipedia

  • Histamine agonist — A histamine agonist is a drug which causes increased activity at one or more of the four histamine receptor subtypes.Betahistine is an example used to treat vertigo.Betazole and impromidine are examples used in diagnostics.ee also* histamine… …   Wikipedia

  • Receptor (biochemistry) — For other uses, see Receptor (disambiguation). In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism. These signals… …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”