Metabotropic glutamate receptor 8

Glutamate receptor, metabotropic 8
Identifiers
Symbols	GRM8; FLJ41058; GLUR8; GPRC1H; MGC126724; MGLUR8; mGlu8
External IDs	OMIM: 601116 MGI: 1351345 HomoloGene: 654 GeneCards: GRM8 Gene
Gene Ontology Molecular function • group III metabotropic glutamate receptor activity • receptor activity • G-protein coupled receptor activity • glutamate receptor activity Cellular component • plasma membrane • integral to plasma membrane • presynaptic membrane • neuron projection • neuronal cell body Biological process • G-protein coupled receptor protein signaling pathway • negative regulation of adenylate cyclase activity • visual perception • sensory perception of smell • negative regulation of cAMP biosynthetic process • synaptic transmission, glutamatergic • regulation of neurotransmitter secretion • response to stimulus Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2918	14823
Ensembl	ENSG00000179603	ENSMUSG00000024211
UniProt	O00222	Q05BD6
RefSeq (mRNA)	NM_000845.2	NM_008174.2
RefSeq (protein)	NP_000836.2	NP_032200.2
Location (UCSC)	Chr 7: 126.08 – 126.89 Mb	Chr 6: 27.23 – 28.09 Mb
PubMed search	[1]	[2]

Metabotropic glutamate receptor 8 is a protein that in humans is encoded by the GRM8 gene.^[1][2]

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.^[2]

Ligands

• (S)-3,4-DCPG: agonist^[3]

See also

• Metabotropic glutamate receptor

References

1. ^ Scherer SW, Duvoisin RM, Kuhn R, Heng HH, Belloni E, Tsui LC (Mar 1997). "Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q". Genomics 31 (2): 230–3. doi:10.1006/geno.1996.0036. PMID 8824806. 
2. ^ ^{a b} "Entrez Gene: GRM8 glutamate receptor, metabotropic 8". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2918. 
3. ^ Thomas NK, Wright RA, Howson PA, Kingston AE, Schoepp DD, Jane DE (2001). "(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord". Neuropharmacology 40 (3): 311–8. doi:10.1016/S0028-3908(00)00169-6. PMID 11166323. http://linkinghub.elsevier.com/retrieve/pii/S0028390800001696. 

External links

• "Metabotropic Glutamate Receptors: mGlu₈". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2282. 

Further reading

• Scherer SW, Soder S, Duvoisin RM, et al. (1997). "The human metabotropic glutamate receptor 8 (GRM8) gene: a disproportionately large gene located at 7q31.3-q32.1". Genomics 44 (2): 232–6. doi:10.1006/geno.1997.4842. PMID 9299241. 
• Wu S, Wright RA, Rockey PK, et al. (1998). "Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells". Brain Res. Mol. Brain Res. 53 (1–2): 88–97. doi:10.1016/S0169-328X(97)00277-5. PMID 9473604. 
• Malherbe P, Kratzeisen C, Lundstrom K, et al. (1999). "Cloning and functional expression of alternative spliced variants of the human metabotropic glutamate receptor 8". Brain Res. Mol. Brain Res. 67 (2): 201–10. doi:10.1016/S0169-328X(99)00050-9. PMID 10216218. 
• Thomas NK, Wright RA, Howson PA, et al. (2001). "(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord". Neuropharmacology 40 (3): 311–8. doi:10.1016/S0028-3908(00)00169-6. PMID 11166323. 
• Enz R (2002). "The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7". FEBS Lett. 514 (2–3): 184–8. doi:10.1016/S0014-5793(02)02361-X. PMID 11943148. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Tang Z, El Far O, Betz H, Scheschonka A (2006). "Pias1 interaction and sumoylation of metabotropic glutamate receptor 8". J. Biol. Chem. 280 (46): 38153–9. doi:10.1074/jbc.M508168200. PMID 16144832. 
• Kobayashi Y, Akiyoshi J, Kanehisa M, et al. (2007). "Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder". Psychiatr. Genet. 17 (1): 9. doi:10.1097/YPG.0b013e32801118bc. PMID 17167337. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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