Metabotropic glutamate receptor 8

Metabotropic glutamate receptor 8
Glutamate receptor, metabotropic 8
Symbols GRM8; FLJ41058; GLUR8; GPRC1H; MGC126724; MGLUR8; mGlu8
External IDs OMIM601116 MGI1351345 HomoloGene654 GeneCards: GRM8 Gene
Species Human Mouse
Entrez 2918 14823
Ensembl ENSG00000179603 ENSMUSG00000024211
UniProt O00222 Q05BD6
RefSeq (mRNA) NM_000845.2 NM_008174.2
RefSeq (protein) NP_000836.2 NP_032200.2
Location (UCSC) Chr 7:
126.08 – 126.89 Mb
Chr 6:
27.23 – 28.09 Mb
PubMed search [1] [2]

Metabotropic glutamate receptor 8 is a protein that in humans is encoded by the GRM8 gene.[1][2]

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Alternative splice variants of GRM8 have been described but their full-length nature has not been determined.[2]



See also


  1. ^ Scherer SW, Duvoisin RM, Kuhn R, Heng HH, Belloni E, Tsui LC (Mar 1997). "Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q". Genomics 31 (2): 230–3. doi:10.1006/geno.1996.0036. PMID 8824806. 
  2. ^ a b "Entrez Gene: GRM8 glutamate receptor, metabotropic 8". 
  3. ^ Thomas NK, Wright RA, Howson PA, Kingston AE, Schoepp DD, Jane DE (2001). "(S)-3,4-DCPG, a potent and selective mGlu8a receptor agonist, activates metabotropic glutamate receptors on primary afferent terminals in the neonatal rat spinal cord". Neuropharmacology 40 (3): 311–8. doi:10.1016/S0028-3908(00)00169-6. PMID 11166323. 

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.