Endothelin receptor

Endothelin receptor

protein
Name=endothelin receptor type A
caption=


width=
HGNCid=3179
Symbol=EDNRA
AltSymbols=
EntrezGene=1909
OMIM=131243
RefSeq=NM_001957
UniProt=P25101
PDB=
ECnumber=
Chromosome=4
Arm=q
Band=31.2
LocusSupplementaryData=protein
Name=endothelin receptor type B
caption=


width=
HGNCid=3180
Symbol=EDNRB
AltSymbols=HSCR2, HSCR
EntrezGene=1910
OMIM=131244
RefSeq=NM_000115
UniProt=P24530
PDB=
ECnumber=
Chromosome=13
Arm=q
Band=22
LocusSupplementaryData=There are at least three known endothelin receptors, ETA, ETB1 and ETB2, all of which are G protein-coupled receptors whose activation result in elevation of intracellular-free calcium.cite journal | author = Davenport AP | title = International Union of Pharmacology. XXIX. Update on endothelin receptor nomenclature | journal = Pharmacol. Rev. | volume = 54 | issue = 2 | pages = 219–26 | year = 2002 | pmid = 12037137 | doi = 10.1124/pr.54.2.219 | issn = ]

Clinical significance

It is associated with ABCD syndromecite journal | author = Verheij JB, Kunze J, Osinga J, van Essen AJ, Hofstra RM | title = ABCD syndrome is caused by a homozygous mutation in the EDNRB gene | journal = Am. J. Med. Genet. | volume = 108 | issue = 3 | pages = 223–5 | year = 2002 | pmid = 11891690 | doi = 10.1002/ajmg.10172 | issn = ] and some forms of Waardenburg syndrome.cite journal | author = Read AP, Newton VE | title = Waardenburg syndrome | journal = J. Med. Genet. | volume = 34 | issue = 8 | pages = 656–65 | year = 1997 | pmid = 9279758 | doi = | issn = ]

ee also

* Endothelin receptor antagonist

References

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1283 IUPHAR GPCR Database - Endothelin Receptors]
*MeshName|Endothelin+receptor


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