Adenosine A2b receptor

Adenosine A2b receptor

The adenosine A2b receptor, also known as ADORA2B, is an adenosine receptor, and also denotes the human gene incoding it.cite web | title = Entrez Gene: ADORA2B adenosine A2b receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=136| accessdate = ]

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Mechanism

This integral membrane protein stimulates adenylate cyclase activity in the presence of adenosine. This protein also interacts with netrin-1, which is involved in axon elongation.

Gene

The gene is located near the Smith-Magenis syndrome region on chromosome 17.cite web | title = Entrez Gene: ADORA2B adenosine A2b receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=136| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Stiles GL |title=Adenosine receptors. |journal=J. Biol. Chem. |volume=267 |issue= 10 |pages= 6451–4 |year= 1992 |pmid= 1551861 |doi=
*cite journal | author=Pierce KD, Furlong TJ, Selbie LA, Shine J |title=Molecular cloning and expression of an adenosine A2b receptor from human brain. |journal=Biochem. Biophys. Res. Commun. |volume=187 |issue= 1 |pages= 86–93 |year= 1992 |pmid= 1325798 |doi=
*cite journal | author=Jacobson MA, Johnson RG, Luneau CJ, Salvatore CA |title=Cloning and chromosomal localization of the human A2b adenosine receptor gene (ADORA2B) and its pseudogene. |journal=Genomics |volume=27 |issue= 2 |pages= 374–6 |year= 1995 |pmid= 7558011 |doi= 10.1006/geno.1995.1061
*cite journal | author=Townsend-Nicholson A, Baker E, Sutherland GR, Schofield PR |title=Localization of the adenosine A2b receptor subtype gene (ADORA2B) to chromosome 17p11.2-p12 by FISH and PCR screening of somatic cell hybrids. |journal=Genomics |volume=25 |issue= 2 |pages= 605–7 |year= 1995 |pmid= 7790006 |doi=
*cite journal | author=Strohmeier GR, Reppert SM, Lencer WI, Madara JL |title=The A2b adenosine receptor mediates cAMP responses to adenosine receptor agonists in human intestinal epithelia. |journal=J. Biol. Chem. |volume=270 |issue= 5 |pages= 2387–94 |year= 1995 |pmid= 7836474 |doi=
*cite journal | author=Feoktistov I, Murray JJ, Biaggioni I |title=Positive modulation of intracellular Ca2+ levels by adenosine A2b receptors, prostacyclin, and prostaglandin E1 via a cholera toxin-sensitive mechanism in human erythroleukemia cells. |journal=Mol. Pharmacol. |volume=45 |issue= 6 |pages= 1160–7 |year= 1994 |pmid= 8022409 |doi=
*cite journal | author=Mirabet M, Herrera C, Cordero OJ, "et al." |title=Expression of A2B adenosine receptors in human lymphocytes: their role in T cell activation. |journal=J. Cell. Sci. |volume=112 ( Pt 4) |issue= |pages= 491–502 |year= 1999 |pmid= 9914161 |doi=
*cite journal | author=Feoktistov I, Goldstein AE, Biaggioni I |title=Role of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinase kinase in adenosine A2B receptor-mediated interleukin-8 production in human mast cells. |journal=Mol. Pharmacol. |volume=55 |issue= 4 |pages= 726–34 |year= 1999 |pmid= 10101031 |doi=
*cite journal | author=Corset V, Nguyen-Ba-Charvet KT, Forcet C, "et al." |title=Netrin-1-mediated axon outgrowth and cAMP production requires interaction with adenosine A2b receptor. |journal=Nature |volume=407 |issue= 6805 |pages= 747–50 |year= 2000 |pmid= 11048721 |doi= 10.1038/35037600
*cite journal | author=Herrera C, Casadó V, Ciruela F, "et al." |title=Adenosine A2B receptors behave as an alternative anchoring protein for cell surface adenosine deaminase in lymphocytes and cultured cells. |journal=Mol. Pharmacol. |volume=59 |issue= 1 |pages= 127–34 |year= 2001 |pmid= 11125033 |doi=
*cite journal | author=Christofi FL, Zhang H, Yu JG, "et al." |title=Differential gene expression of adenosine A1, A2a, A2b, and A3 receptors in the human enteric nervous system. |journal=J. Comp. Neurol. |volume=439 |issue= 1 |pages= 46–64 |year= 2001 |pmid= 11579381 |doi= 10.1002/cne.1334
*cite journal | author=Hayallah AM, Sandoval-Ramírez J, Reith U, "et al." |title=1,8-disubstituted xanthine derivatives: synthesis of potent A2B-selective adenosine receptor antagonists. |journal=J. Med. Chem. |volume=45 |issue= 7 |pages= 1500–10 |year= 2002 |pmid= 11906291 |doi=
*cite journal | author=Sitaraman SV, Wang L, Wong M, "et al." |title=The adenosine 2b receptor is recruited to the plasma membrane and associates with E3KARP and Ezrin upon agonist stimulation. |journal=J. Biol. Chem. |volume=277 |issue= 36 |pages= 33188–95 |year= 2002 |pmid= 12080047 |doi= 10.1074/jbc.M202522200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Feoktistov I, Ryzhov S, Goldstein AE, Biaggioni I |title=Mast cell-mediated stimulation of angiogenesis: cooperative interaction between A2B and A3 adenosine receptors. |journal=Circ. Res. |volume=92 |issue= 5 |pages= 485–92 |year= 2003 |pmid= 12600879 |doi= 10.1161/01.RES.0000061572.10929.2D
*cite journal | author=Eltzschig HK, Ibla JC, Furuta GT, "et al." |title=Coordinated adenine nucleotide phosphohydrolysis and nucleoside signaling in posthypoxic endothelium: role of ectonucleotidases and adenosine A2B receptors. |journal=J. Exp. Med. |volume=198 |issue= 5 |pages= 783–96 |year= 2003 |pmid= 12939345 |doi= 10.1084/jem.20030891
*cite journal | author=Ryzhov S, Goldstein AE, Matafonov A, "et al." |title=Adenosine-activated mast cells induce IgE synthesis by B lymphocytes: an A2B-mediated process involving Th2 cytokines IL-4 and IL-13 with implications for asthma. |journal=J. Immunol. |volume=172 |issue= 12 |pages= 7726–33 |year= 2004 |pmid= 15187156 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kolachala V, Asamoah V, Wang L, "et al." |title=Interferon-gamma down-regulates adenosine 2b receptor-mediated signaling and short circuit current in the intestinal epithelia by inhibiting the expression of adenylate cyclase. |journal=J. Biol. Chem. |volume=280 |issue= 6 |pages= 4048–57 |year= 2005 |pmid= 15550390 |doi= 10.1074/jbc.M409577200

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