Melatonin receptor 1A

Melatonin receptor 1A
Identifiers
Symbols	MTNR1A; MEL-1A-R; MT1
External IDs	OMIM: 600665 MGI: 102967 HomoloGene: 21207 IUPHAR: MT1 GeneCards: MTNR1A Gene
Gene Ontology Molecular function • receptor activity • melatonin receptor activity Cellular component • plasma membrane • plasma membrane • integral to plasma membrane Biological process • G-protein signaling, coupled to cyclic nucleotide second messenger • mating behavior • circadian rhythm Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4543	17773
Ensembl	ENSG00000168412	ENSMUSG00000054764
UniProt	P48039	Q14AC3
RefSeq (mRNA)	NM_005958	NM_008639.2
RefSeq (protein)	NP_005949	NP_032665.1
Location (UCSC)	Chr 4: 187.35 – 187.48 Mb	Chr 8: 46.15 – 46.17 Mb
PubMed search	[1]	[2]

Melatonin receptor type 1A is a protein that in humans is encoded by the MTNR1A gene.^[1][2]

This gene encodes the MT₁ protein, one of two high-affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G protein-coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin.^[2]

See also

• Melatonin receptor
• Discovery and development of melatonin receptor agonists

References

1. ^ Slaugenhaupt SA, Roca AL, Liebert CB, Altherr MR, Gusella JF, Reppert SM (Nov 1995). "Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a)". Genomics 27 (2): 355–7. doi:10.1006/geno.1995.1056. PMID 7558006. 
2. ^ ^{a b} "Entrez Gene: MTNR1A melatonin receptor 1A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4543. 

External links

• "Melatonin Receptors: MT₁". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2359. 

Further reading

• Brzezinski A; Brzezinski, Amnon (1997). "Melatonin in humans". N. Engl. J. Med. 336 (3): 186–95. doi:10.1056/NEJM199701163360306. PMID 8988899. 
• Khan AU, Olson DL (1975). "Physical therapy and exercise-induced bronchospasm". Physical therapy 55 (8): 878–81. PMID 1144527. 
• Reppert SM, Weaver DR, Ebisawa T (1994). "Cloning and characterization of a mammalian melatonin receptor that mediates reproductive and circadian responses". Neuron 13 (5): 1177–85. doi:10.1016/0896-6273(94)90055-8. PMID 7946354. 
• Witt-Enderby PA, Dubocovich ML (1996). "Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells". Mol. Pharmacol. 50 (1): 166–74. PMID 8700109. 
• Witt-Enderby PA, Masana MI, Dubocovich ML (1998). "Physiological exposure to melatonin supersensitizes the cyclic adenosine 3',5'-monophosphate-dependent signal transduction cascade in Chinese hamster ovary cells expressing the human mt1 melatonin receptor". Endocrinology 139 (7): 3064–71. doi:10.1210/en.139.7.3064. PMID 9645677. 
• Ebisawa T, Kajimura N, Uchiyama M et al. (1999). "Alleic variants of human melatonin 1a receptor: function and prevalence in subjects with circadian rhythm sleep disorders". Biochem. Biophys. Res. Commun. 262 (3): 832–7. doi:10.1006/bbrc.1999.1308. PMID 10471411. 
• Brydon L, Roka F, Petit L et al. (2000). "Dual signaling of human Mel1a melatonin receptors via G(i2), G(i3), and G(q/11) proteins". Mol. Endocrinol. 13 (12): 2025–38. doi:10.1210/me.13.12.2025. PMID 10598579. 
• Niles LP, Wang J, Shen L et al. (2000). "Melatonin receptor mRNA expression in human granulosa cells". Mol. Cell. Endocrinol. 156 (1–2): 107–10. doi:10.1016/S0303-7207(99)00135-5. PMID 10612428. 
• Song CK, Bartness TJ (2001). "CNS sympathetic outflow neurons to white fat that express MEL receptors may mediate seasonal adiposity". Am. J. Physiol. Regul. Integr. Comp. Physiol. 281 (2): R666–72. PMID 11448873. 
• Roy D, Angelini NL, Fujieda H et al. (2001). "Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin". Endocrinology 142 (11): 4711–20. doi:10.1210/en.142.11.4711. PMID 11606436. 
• Savaskan E, Olivieri G, Meier F et al. (2002). "Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients". J. Pineal Res. 32 (1): 59–62. doi:10.1034/j.1600-079x.2002.00841.x. PMID 11841602. 
• Savaskan E, Wirz-Justice A, Olivieri G et al. (2002). "Distribution of melatonin MT1 receptor immunoreactivity in human retina". J. Histochem. Cytochem. 50 (4): 519–26. PMID 11897804. 
• Ayoub MA, Couturier C, Lucas-Meunier E et al. (2002). "Monitoring of ligand-independent dimerization and ligand-induced conformational changes of melatonin receptors in living cells by bioluminescence resonance energy transfer". J. Biol. Chem. 277 (24): 21522–8. doi:10.1074/jbc.M200729200. PMID 11940583. 
• Yuan L, Collins AR, Dai J et al. (2003). "MT(1) melatonin receptor overexpression enhances the growth suppressive effect of melatonin in human breast cancer cells". Mol. Cell. Endocrinol. 192 (1–2): 147–56. doi:10.1016/S0303-7207(02)00029-1. PMID 12088876. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Slominski A, Pisarchik A, Zbytek B et al. (2003). "Functional activity of serotoninergic and melatoninergic systems expressed in the skin". J. Cell. Physiol. 196 (1): 144–53. doi:10.1002/jcp.10287. PMID 12767050. 
• Morcuende JA, Minhas R, Dolan L et al. (2004). "Allelic variants of human melatonin 1A receptor in patients with familial adolescent idiopathic scoliosis". Spine 28 (17): 2025–8; discussion 2029. doi:10.1097/01.BRS.0000083235.74593.49. PMID 12973153. 
• Aust S, Thalhammer T, Humpeler S et al. (2004). "The melatonin receptor subtype MT1 is expressed in human gallbladder epithelia". J. Pineal Res. 36 (1): 43–8. doi:10.1046/j.1600-079X.2003.00095.x. PMID 14675129. 

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