Tachykinin receptor 3

Tachykinin receptor 3, also known as TACR3, is a human gene.cite web | title = Entrez Gene: TACR3 tachykinin receptor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6870| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene belongs to a family of genes that function as receptors for tachykinins. Receptor affinities are specified by variations in the 5'-end of the sequence. The receptors belonging to this family are characterized by interactions with G proteins and 7 hydrophobic transmembrane regions. This gene encodes the receptor for the tachykinin neurokinin 3, also referred to as neurokinin B.cite web | title = Entrez Gene: TACR3 tachykinin receptor 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6870| accessdate = ]

elective Ligands

Several selective ligands are available for NK₃, with two compounds Osanetant and Talnetant currently in clinical trials for treatment of schizophrenia and other indications.

Agonists

* Senktide - 7-amino acid polypeptide, NK₃ selective, CAS# 106128-89-6

Antagonists

* Osanetant
* Talnetant
* SB-222,200 - potent and selective antagonist, Ki 4.4nM, 3-Methyl-2-phenyl-N- [(1S)-1-phenylpropyl] -4-quinolinecarboxamide, CAS# 174635-69-9
* SB-218,795 - more selective than SB-222,200, Ki 13nM, (R)- [(2-Phenyl-4-quinolinylcarbonyl)amino] -methyl ester benzeneacetic acid, CAS# 174635-53-1

ee also

* Tachykinin receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Khawaja AM, Rogers DF |title=Tachykinins: receptor to effector. |journal=Int. J. Biochem. Cell Biol. |volume=28 |issue= 7 |pages= 721–38 |year= 1996 |pmid= 8925404 |doi=
*cite journal | author=Advenier C, Lagente V, Boichot E |title=The role of tachykinin receptor antagonists in the prevention of bronchial hyperresponsiveness, airway inflammation and cough. |journal=Eur. Respir. J. |volume=10 |issue= 8 |pages= 1892–906 |year= 1997 |pmid= 9272936 |doi=
*cite journal | author=Buell G, Schulz MF, Arkinstall SJ, "et al." |title=Molecular characterisation, expression and localisation of human neurokinin-3 receptor. |journal=FEBS Lett. |volume=299 |issue= 1 |pages= 90–5 |year= 1992 |pmid= 1312036 |doi=
*cite journal | author=Takahashi K, Tanaka A, Hara M, Nakanishi S |title=The primary structure and gene organization of human substance P and neuromedin K receptors. |journal=Eur. J. Biochem. |volume=204 |issue= 3 |pages= 1025–33 |year= 1992 |pmid= 1312928 |doi=
*cite journal | author=Xie GX, Miyajima A, Goldstein A |title=Expression cloning of cDNA encoding a seven-helix receptor from human placenta with affinity for opioid ligands. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 9 |pages= 4124–8 |year= 1992 |pmid= 1315051 |doi=
*cite journal | author=Huang RR, Cheung AH, Mazina KE, "et al." |title=cDNA sequence and heterologous expression of the human neurokinin-3 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=184 |issue= 2 |pages= 966–72 |year= 1992 |pmid= 1374246 |doi=
*cite journal | author=Dion S, Corcos J, Carmel M, "et al." |title=Substance P and neurokinins as stimulants of the human isolated urinary bladder. |journal=Neuropeptides |volume=11 |issue= 2 |pages= 83–7 |year= 1988 |pmid= 2452993 |doi=
*cite journal | author=Krause JE, Staveteig PT, Mentzer JN, "et al." |title=Functional expression of a novel human neurokinin-3 receptor homolog that binds [3H] senktide and [125I-MePhe7] neurokinin B, and is responsive to tachykinin peptide agonists. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 1 |pages= 310–5 |year= 1997 |pmid= 8990205 |doi=
*cite journal | author=Brunelleschi S, Bordin G, Colangelo D, Viano I |title=Tachykinin receptors on human monocytes: their involvement in rheumatoid arthritis. |journal=Neuropeptides |volume=32 |issue= 3 |pages= 215–23 |year= 1999 |pmid= 10189055 |doi=
*cite journal | author=Page NM, Woods RJ, Gardiner SM, "et al." |title=Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. |journal=Nature |volume=405 |issue= 6788 |pages= 797–800 |year= 2000 |pmid= 10866201 |doi= 10.1038/35015579
*cite journal | author=Bellucci F, Carini F, Catalani C, "et al." |title=Pharmacological profile of the novel mammalian tachykinin, hemokinin 1. |journal=Br. J. Pharmacol. |volume=135 |issue= 1 |pages= 266–74 |year= 2002 |pmid= 11786503 |doi= 10.1038/sj.bjp.0704443
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Graham GJ, Stevens JM, Page NM, "et al." |title=Tachykinins regulate the function of platelets. |journal=Blood |volume=104 |issue= 4 |pages= 1058–65 |year= 2005 |pmid= 15130944 |doi= 10.1182/blood-2003-11-3979
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Page NM, Dakour J, Morrish DW |title=Gene regulation of neurokinin B and its receptor NK3 in late pregnancy and pre-eclampsia. |journal=Mol. Hum. Reprod. |volume=12 |issue= 7 |pages= 427–33 |year= 2006 |pmid= 16709596 |doi= 10.1093/molehr/gal025

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