- Tachykinin receptor
-
tachykinin receptor 1 Identifiers Symbol TACR1 Alt. symbols TAC1R Entrez 6869 HUGO 11526 OMIM 162323 RefSeq NM_001058 UniProt P25103 Other data Locus Chr. 2 p13.1-p12 tachykinin receptor 2 Identifiers Symbol TACR2 Alt. symbols TAC2R, NKNAR Entrez 6865 HUGO 11527 OMIM 162321 RefSeq NM_001057 UniProt P21452 Other data Locus Chr. 10 q11-q21 tachykinin receptor 3 Identifiers Symbol TACR3 Entrez 6870 HUGO 11528 OMIM 162332 RefSeq NM_001059 UniProt P29371 Other data Locus Chr. 4 q25 There are three known mammalian tachykinin receptors termed NK1, NK2 and NK3. All are members of the 7 transmembrane G-protein coupled receptor family and induce the activation of phospholipase C, producing inositol triphosphate (so called Gq-coupled).
Contents
Binding
The genes and receptor ligands are as follows:[1]
Receptor Gene Preferred ligand NK1 TACR1 substance P NK2 TACR2 neurokinin A NK3 TACR3 neurokinin B (Hökfelt et al., 2001; Page, 2004; Pennefather et al., 2004; Maggi, 2000)
See also
- Substance P
- G protein coupled receptors
References
- ^ Maggi CA (1995). "The mammalian tachykinin receptors". Gen. Pharmacol. 26 (5): 911–44. doi:10.1016/0306-3623(94)00292-U. PMID 7557266.
External links
- "Tachykinin Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1354.
- MeSH Tachykinin+Receptor
Neuropeptide receptors G protein-coupled receptor OtherOther neuropeptide receptorsAngiotensin · Bradykinin (B1, B2) / Tachykinin (TACR1) · Calcitonin gene-related peptide · Galanin · GPCR neuropeptide (B/W, FF, S, Y) · NeurotensinType I cytokine receptor Enzyme-linked receptor Other Neuropeptidergics Cholecystokinin Agonists: Cholecystokinin • CCK-4
Antagonists: Asperlicin • Proglumide • Lorglumide • Devazepide • DexloxiglumideCRH Agonists: Corticotropin releasing hormoneGalanin Agonists: Galanin • Galanin-like peptide • Galmic • GalnonAgonists: Galanin • Galanin-like peptide • Galmic • GalnonAgonists: Galanin • Galmic • GalnonGhrelin MCH Agonists: Melanin concentrating hormone
Antagonists: ATC-0175 • GW-803,430 • NGD-4715 • SNAP-7941 • SNAP-94847Agonists: Melanin concentrating hormoneMelanocortin Agonists: alpha-MSH • Afamelanotide • Bremelanotide • Melanotan II
Antagonists: Agouti signalling peptideAgonists: alpha-MSH • Bremelanotide • Melanotan IIAgonists: alpha-MSH • Melanotan IINeuropeptide S Agonists: Neuropeptide S
Antagonists: SHA-68Neuropeptide Y Neurotensin Opioid see Template:OpioidsOrexin Oxytocin Agonists: Carbetocin • Demoxytocin • Oxytocin • WAY-267,464
Antagonists: Atosiban • Epelsiban • L-371,257 • L-368,899Tachykinin Agonists: Substance P
Antagonists: Aprepitant • Befetupitant • Casopitant • CI-1021 • CP-96,345 • CP-99,994 • CP-122,721 • Dapitant • Ezlopitant • FK-888 • Fosaprepitant • GR-203,040 • GW-597,599 • HSP-117 • L-733,060 • L-741,671 • L-743,310 • L-758,298 • Lanepitant • LY-306,740 • Maropitant • Netupitant • NKP-608 • Nolpitantium • Orvepitant • RP-67,580 • SDZ NKT 343 • Vestipitant • VofopitantVasopressin Agonists: Desmopressin • Felypressin • Ornipressin • Terlipressin • Vasopressin
Antagonists: Conivaptan • Demeclocycline • RelcovaptanAgonists: Felypressin • Ornipressin • Terlipressin • Vasopressin
Antagonists: Demeclocycline • NelivaptanAgonists: Desmopressin • Ornipressin • Vasopressin
Antagonists: Conivaptan • Demeclocycline • Lixivaptan • Mozavaptan • Satavaptan • TolvaptanCategories:- Genes on chromosome 2
- Genes on chromosome 10
- Genes on chromosome 4
- Biochemistry stubs
- G protein coupled receptors
- Molecular neuroscience
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