The alpha-1A adrenergic receptor (α1A adrenoreceptor), also known as ADRA1A, formerly known as the alpha-1C adrenergic receptor [cite journal |author=Langer SZ |title=Nomenclature and state of the art on alpha1-adrenoceptors |journal=Eur. Urol. |volume=33 Suppl 2 |issue= |pages=2–6 |year=1998 |pmid=9556189 |doi=] , is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.
PBB_Summary
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Receptor
There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation.
Gene
This gene encodes the alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties.[cite web | title = Entrez Gene: ADRA1A adrenergic, alpha-1A-, receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=148| accessdate = ] ]Antagonists
Alpha-blockers specific for 1A include tamsulosin (in benign prostatic hyperplasia.
ee also
*Adrenergic receptor
References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Mátyus P, Horváth K |title=Alpha-adrenergic approach in the medical management of benign prostatic hyperplasia. |journal=Med Res Rev |volume=17 |issue= 6 |pages= 523–35 |year= 1998 |pmid= 9359081 |doi=
*cite journal | author=Hoehe MR, Berrettini WH, Schwinn DA, Hsieh WT |title=A two-allele PstI RFLP for the alpha-1C adrenergic receptor gene (ADRA1C). |journal=Hum. Mol. Genet. |volume=1 |issue= 5 |pages= 349 |year= 1993 |pmid= 1363873 |doi=
*cite journal | author=Schwinn DA, Lomasney JW, Lorenz W, "et al." |title=Molecular cloning and expression of the cDNA for a novel alpha 1-adrenergic receptor subtype. |journal=J. Biol. Chem. |volume=265 |issue= 14 |pages= 8183–9 |year= 1990 |pmid= 1970822 |doi=
*cite journal | author=Hirasawa A, Shibata K, Horie K, "et al." |title=Cloning, functional expression and tissue distribution of human alpha 1c-adrenoceptor splice variants. |journal=FEBS Lett. |volume=363 |issue= 3 |pages= 256–60 |year= 1995 |pmid= 7737411 |doi=
*cite journal | author=Diehl NL, Shreeve SM |title=Identification of the alpha 1c-adrenoceptor in rabbit arteries and the human saphenous vein using the polymerase chain reaction. |journal=Eur. J. Pharmacol. |volume=268 |issue= 3 |pages= 393–8 |year= 1995 |pmid= 7805763 |doi=
*cite journal | author=Schwinn DA, Johnston GI, Page SO, "et al." |title=Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. |journal=J. Pharmacol. Exp. Ther. |volume=272 |issue= 1 |pages= 134–42 |year= 1995 |pmid= 7815325 |doi=
*cite journal | author=Weinberg DH, Trivedi P, Tan CP, "et al." |title=Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c. |journal=Biochem. Biophys. Res. Commun. |volume=201 |issue= 3 |pages= 1296–304 |year= 1994 |pmid= 8024574 |doi=
*cite journal | author=Forray C, Bard JA, Wetzel JM, "et al." |title=The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. |journal=Mol. Pharmacol. |volume=45 |issue= 4 |pages= 703–8 |year= 1994 |pmid= 8183249 |doi=
*cite journal | author=Hirasawa A, Horie K, Tanaka T, "et al." |title=Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor. |journal=Biochem. Biophys. Res. Commun. |volume=195 |issue= 2 |pages= 902–9 |year= 1993 |pmid= 8396931 |doi= 10.1006/bbrc.1993.2130
*cite journal | author=Tseng-Crank J, Kost T, Goetz A, "et al." |title=The alpha 1C-adrenoceptor in human prostate: cloning, functional expression, and localization to specific prostatic cell types. |journal=Br. J. Pharmacol. |volume=115 |issue= 8 |pages= 1475–85 |year= 1996 |pmid= 8564208 |doi=
*cite journal | author=Shibata K, Hirasawa A, Moriyama N, "et al." |title=Alpha 1a-adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy. |journal=Br. J. Pharmacol. |volume=118 |issue= 6 |pages= 1403–8 |year= 1997 |pmid= 8832064 |doi=
*cite journal | author=Chang DJ, Chang TK, Yamanishi SS, "et al." |title=Molecular cloning, genomic characterization and expression of novel human alpha1A-adrenoceptor isoforms. |journal=FEBS Lett. |volume=422 |issue= 2 |pages= 279–83 |year= 1998 |pmid= 9490024 |doi=
*cite journal | author=Daniels DV, Gever JR, Jasper JR, "et al." |title=Human cloned alpha1A-adrenoceptor isoforms display alpha1L-adrenoceptor pharmacology in functional studies. |journal=Eur. J. Pharmacol. |volume=370 |issue= 3 |pages= 337–43 |year= 1999 |pmid= 10334511 |doi=
*cite journal | author=Cogé F, Guenin SP, Renouard-Try A, "et al." |title=Truncated isoforms inhibit [3H] prazosin binding and cellular trafficking of native human alpha1A-adrenoceptors. |journal=Biochem. J. |volume=343 Pt 1 |issue= |pages= 231–9 |year= 1999 |pmid= 10493934 |doi=
*cite journal | author=Rudner XL, Berkowitz DE, Booth JV, "et al." |title=Subtype specific regulation of human vascular alpha(1)-adrenergic receptors by vessel bed and age. |journal=Circulation |volume=100 |issue= 23 |pages= 2336–43 |year= 1999 |pmid= 10587338 |doi=
*cite journal | author=Ballou LM, Cross ME, Huang S, "et al." |title=Differential regulation of the phosphatidylinositol 3-kinase/Akt and p70 S6 kinase pathways by the alpha(1A)-adrenergic receptor in rat-1 fibroblasts. |journal=J. Biol. Chem. |volume=275 |issue= 7 |pages= 4803–9 |year= 2000 |pmid= 10671514 |doi=
*cite journal | author=Keffel S, Alexandrov A, Goepel M, Michel MC |title=alpha(1)-adrenoceptor subtypes differentially couple to growth promotion and inhibition in Chinese hamster ovary cells. |journal=Biochem. Biophys. Res. Commun. |volume=272 |issue= 3 |pages= 906–11 |year= 2000 |pmid= 10860850 |doi= 10.1006/bbrc.2000.2850
*cite journal | author=Richman JG, Brady AE, Wang Q, "et al." |title=Agonist-regulated Interaction between alpha2-adrenergic receptors and spinophilin. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 15003–8 |year= 2001 |pmid= 11154706 |doi= 10.1074/jbc.M011679200
*cite journal | author=Shibata K, Katsuma S, Koshimizu T, "et al." |title=alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1. |journal=J. Biol. Chem. |volume=278 |issue= 1 |pages= 672–8 |year= 2003 |pmid= 12409310 |doi= 10.1074/jbc.M201375200
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