The alpha-1D adrenergic receptor (α1D adrenoreceptor), also known as ADRA1D, is an alpha-1 adrenergic receptor, and also denotes the human gene encoding it.
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Receptor
There are 3 alpha-1 adrenergic receptor subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. They activate mitogenic responses and regulate growth and proliferation of many cells.
Gene
This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.[cite web | title = Entrez Gene: ADRA1D adrenergic, alpha-1D-, receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=146| accessdate = ] ]ee also
*Adrenergic receptor
References
Further reading
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*cite journal | author=Schwinn DA, Lomasney JW |title=Pharmacologic characterization of cloned alpha 1-adrenoceptor subtypes: selective antagonists suggest the existence of a fourth subtype. |journal=Eur. J. Pharmacol. |volume=227 |issue= 4 |pages= 433–6 |year= 1992 |pmid= 1359975 |doi=
*cite journal | author=Bruno JF, Whittaker J, Song JF, Berelowitz M |title=Molecular cloning and sequencing of a cDNA encoding a human alpha 1A adrenergic receptor. |journal=Biochem. Biophys. Res. Commun. |volume=179 |issue= 3 |pages= 1485–90 |year= 1991 |pmid= 1656955 |doi=
*cite journal | author=Esbenshade TA, Hirasawa A, Tsujimoto G, "et al." |title=Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells. |journal=Mol. Pharmacol. |volume=47 |issue= 5 |pages= 977–85 |year= 1995 |pmid= 7746284 |doi=
*cite journal | author=Schwinn DA, Johnston GI, Page SO, "et al." |title=Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. |journal=J. Pharmacol. Exp. Ther. |volume=272 |issue= 1 |pages= 134–42 |year= 1995 |pmid= 7815325 |doi=
*cite journal | author=Weinberg DH, Trivedi P, Tan CP, "et al." |title=Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c. |journal=Biochem. Biophys. Res. Commun. |volume=201 |issue= 3 |pages= 1296–304 |year= 1994 |pmid= 8024574 |doi=
*cite journal | author=Loftus SK, Shiang R, Warrington JA, "et al." |title=Genes encoding adrenergic receptors are not clustered on the long arm of human chromosome 5. |journal=Cytogenet. Cell Genet. |volume=67 |issue= 2 |pages= 69–74 |year= 1994 |pmid= 8039425 |doi=
*cite journal | author=Yang-Feng TL, Han H, Lomasney JW, Caron MG |title=Localization of the cDNA for an alpha 1-adrenergic receptor subtype (ADRA1D) to chromosome band 20p13. |journal=Cytogenet. Cell Genet. |volume=66 |issue= 3 |pages= 170–1 |year= 1994 |pmid= 8125015 |doi=
*cite journal | author=Forray C, Bard JA, Wetzel JM, "et al." |title=The alpha 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human alpha 1c subtype. |journal=Mol. Pharmacol. |volume=45 |issue= 4 |pages= 703–8 |year= 1994 |pmid= 8183249 |doi=
*cite journal | author=Minneman KP, Lee D, Zhong H, "et al." |title=Transcriptional responses to growth factor and G protein-coupled receptors in PC12 cells: comparison of alpha(1)-adrenergic receptor subtypes. |journal=J. Neurochem. |volume=74 |issue= 6 |pages= 2392–400 |year= 2000 |pmid= 10820200 |doi=
*cite journal | author=Keffel S, Alexandrov A, Goepel M, Michel MC |title=alpha(1)-adrenoceptor subtypes differentially couple to growth promotion and inhibition in Chinese hamster ovary cells. |journal=Biochem. Biophys. Res. Commun. |volume=272 |issue= 3 |pages= 906–11 |year= 2000 |pmid= 10860850 |doi= 10.1006/bbrc.2000.2850
*cite journal | author=Kyprianou N, Benning CM |title=Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis. |journal=Cancer Res. |volume=60 |issue= 16 |pages= 4550–5 |year= 2000 |pmid= 10969806 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Shibata K, Katsuma S, Koshimizu T, "et al." |title=alpha 1-Adrenergic receptor subtypes differentially control the cell cycle of transfected CHO cells through a cAMP-dependent mechanism involving p27Kip1. |journal=J. Biol. Chem. |volume=278 |issue= 1 |pages= 672–8 |year= 2003 |pmid= 12409310 |doi= 10.1074/jbc.M201375200
*cite journal | author=Pupo AS, Minneman KP |title=Specific interactions between gC1qR and alpha1-adrenoceptor subtypes. |journal=J. Recept. Signal Transduct. Res. |volume=23 |issue= 2-3 |pages= 185–95 |year= 2004 |pmid= 14626446 |doi=
*cite journal | author=Hague C, Uberti MA, Chen Z, "et al." |title=Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors. |journal=J. Biol. Chem. |volume=279 |issue= 15 |pages= 15541–9 |year= 2004 |pmid= 14736874 |doi= 10.1074/jbc.M314014200
*cite journal | author=Gonzalez-Cabrera PJ, Shi T, Yun J, "et al." |title=Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes. |journal=Endocrinology |volume=145 |issue= 11 |pages= 5157–67 |year= 2004 |pmid= 15297446 |doi= 10.1210/en.2004-0728
*cite journal | author=Zhang T, Xu Q, Chen FR, "et al." |title=Yeast two-hybrid screening for proteins that interact with alpha1-adrenergic receptors. |journal=Acta Pharmacol. Sin. |volume=25 |issue= 11 |pages= 1471–8 |year= 2005 |pmid= 15525470 |doi=
*cite journal | author=Sigala S, Dellabella M, Milanese G, "et al." |title=Evidence for the presence of alpha1 adrenoceptor subtypes in the human ureter. |journal=Neurourol. Urodyn. |volume=24 |issue= 2 |pages= 142–8 |year= 2005 |pmid= 15690361 |doi= 10.1002/nau.20097
*cite journal | author=Chen Z, Hague C, Hall RA, Minneman KP |title=Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction. |journal=J. Biol. Chem. |volume=281 |issue= 18 |pages= 12414–20 |year= 2006 |pmid= 16533813 |doi= 10.1074/jbc.M508651200
*cite journal | author=Michelotti GA, Brinkley DM, Morris DP, "et al." |title=Epigenetic regulation of human alpha1d-adrenergic receptor gene expression: a role for DNA methylation in Sp1-dependent regulation. |journal=FASEB J. |volume=21 |issue= 9 |pages= 1979–93 |year= 2007 |pmid= 17384146 |doi= 10.1096/fj.06-7118com
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