Thyrotropin-releasing hormone receptor

Thyrotropin-releasing hormone receptor

The thyrotropin-releasing hormone receptor (TRHR) is a G protein-coupled receptor which binds the tripeptide thyrotropin releasing hormone.cite journal | author = Yamada M, Monden T, Konaka S, Mori M | title = Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8 | journal = Somat. Cell Mol. Genet. | volume = 19 | issue = 6 | pages = 577–80 | year = 1993 | pmid = 8128317 | doi = | issn = ] cite journal | author = Gershengorn MC | title = Thyrotropin-releasing hormone receptor: cloning and regulation of its expression | journal = Recent Prog. Horm. Res. | volume = 48 | issue = | pages = 341–63 | year = 1993 | pmid = 8382829 | doi = | issn = ] The TRHR are found in the brain and when bound by TRH result act through phospholipase C to increase intracellular inositol triphosphate.


Further reading

citations =
*cite journal | author=Short RE, James LF, Panter KE, "et al." |title=Effects of feeding ponderosa pine needles during pregnancy: comparative studies with bison, cattle, goats, and sheep. |journal=J. Anim. Sci. |volume=70 |issue= 11 |pages= 3498–504 |year= 1993 |pmid= 1459912 |doi=
*cite journal | author=Yamada M, Iwasaki T, Satoh T, "et al." |title=Activation of the thyrotropin-releasing hormone (TRH) receptor by a direct precursor of TRH, TRH-Gly. |journal=Neurosci. Lett. |volume=196 |issue= 1-2 |pages= 109–12 |year= 1996 |pmid= 7501234 |doi=
*cite journal | author=Hinuma S, Hosoya M, Ogi K, "et al." |title=Molecular cloning and functional expression of a human thyrotropin-releasing hormone (TRH) receptor gene. |journal=Biochim. Biophys. Acta |volume=1219 |issue= 2 |pages= 251–9 |year= 1994 |pmid= 7918619 |doi=
*cite journal | author=Morrison N, Duthie SM, Boyd E, "et al." |title=Assignment of the gene encoding the human thyrotropin-releasing hormone receptor to 8q23 by fluorescence in situ hybridization. |journal=Hum. Genet. |volume=93 |issue= 6 |pages= 716–8 |year= 1994 |pmid= 8005602 |doi=
*cite journal | author=Yamada M, Monden T, Konaka S, Mori M |title=Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8. |journal=Somat. Cell Mol. Genet. |volume=19 |issue= 6 |pages= 577–80 |year= 1994 |pmid= 8128317 |doi=
*cite journal | author=Duthie SM, Taylor PL, Anderson L, "et al." |title=Cloning and functional characterisation of the human TRH receptor. |journal=Mol. Cell. Endocrinol. |volume=95 |issue= 1-2 |pages= R11–5 |year= 1994 |pmid= 8243797 |doi=
*cite journal | author=Matre V, Karlsen HE, Wright MS, "et al." |title=Molecular cloning of a functional human thyrotropin-releasing hormone receptor. |journal=Biochem. Biophys. Res. Commun. |volume=195 |issue= 1 |pages= 179–85 |year= 1993 |pmid= 8395824 |doi= 10.1006/bbrc.1993.2027
*cite journal | author=Yamada M, Monden T, Satoh T, "et al." |title=Pituitary adenomas of patients with acromegaly express thyrotropin-releasing hormone receptor messenger RNA: cloning and functional expression of the human thyrotropin-releasing hormone receptor gene. |journal=Biochem. Biophys. Res. Commun. |volume=195 |issue= 2 |pages= 737–45 |year= 1993 |pmid= 8396925 |doi= 10.1006/bbrc.1993.2107
*cite journal | author=Iwasaki T, Yamada M, Satoh T, "et al." |title=Genomic organization and promoter function of the human thyrotropin-releasing hormone receptor gene. |journal=J. Biol. Chem. |volume=271 |issue= 36 |pages= 22183–8 |year= 1996 |pmid= 8703031 |doi=
*cite journal | author=Cook JV, McGregor A, Lee T, "et al." |title=A disulfide bonding interaction role for cysteines in the extracellular domain of the thyrotropin-releasing hormone receptor. |journal=Endocrinology |volume=137 |issue= 7 |pages= 2851–8 |year= 1996 |pmid= 8770906 |doi=
*cite journal | author=Collu R, Tang J, Castagné J, "et al." |title=A novel mechanism for isolated central hypothyroidism: inactivating mutations in the thyrotropin-releasing hormone receptor gene. |journal=J. Clin. Endocrinol. Metab. |volume=82 |issue= 5 |pages= 1561–5 |year= 1997 |pmid= 9141550 |doi=
*cite journal | author=Petrou C, Tashjian AH |title=The thyrotropin-releasing hormone-receptor complex and G11alpha are both internalised into clathrin-coated vesicles. |journal=Cell. Signal. |volume=10 |issue= 8 |pages= 553–9 |year= 1999 |pmid= 9794253 |doi=
*cite journal | author=Matre V, Høvring PI, Orstavik S, "et al." |title=Structural and functional organization of the gene encoding the human thyrotropin-releasing hormone receptor. |journal=J. Neurochem. |volume=72 |issue= 1 |pages= 40–50 |year= 1999 |pmid= 9886052 |doi=
*cite journal | author=Kroeger KM, Hanyaloglu AC, Seeber RM, "et al." |title=Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 12736–43 |year= 2001 |pmid= 11278883 |doi= 10.1074/jbc.M011311200
*cite journal | author=Zhu CC, Cook LB, Hinkle PM |title=Dimerization and phosphorylation of thyrotropin-releasing hormone receptors are modulated by agonist stimulation. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28228–37 |year= 2002 |pmid= 12023974 |doi= 10.1074/jbc.M204221200
*cite journal | author=Hanyaloglu AC, Seeber RM, Kohout TA, "et al." |title=Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2. |journal=J. Biol. Chem. |volume=277 |issue= 52 |pages= 50422–30 |year= 2003 |pmid= 12393857 |doi= 10.1074/jbc.M209340200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Cook LB, Zhu CC, Hinkle PM |title=Thyrotropin-releasing hormone receptor processing: role of ubiquitination and proteasomal degradation. |journal=Mol. Endocrinol. |volume=17 |issue= 9 |pages= 1777–91 |year= 2004 |pmid= 12805411 |doi= 10.1210/me.2003-0073
*cite journal | author=Igarashi-Migitaka J, Yamada S, Hara M, "et al." |title=Gene expression study of thyrotropin releasing hormone (TRH) receptor using RT-PCR: relationship to clinical and immunohistochemical phenotypes in a series of human pituitary adenomas. |journal=Endocr. J. |volume=50 |issue= 4 |pages= 459–67 |year= 2004 |pmid= 14599121 |doi=
*cite journal | author=Cook LB, Hinkle PM |title=Fate of internalized thyrotropin-releasing hormone receptors monitored with a timer fusion protein. |journal=Endocrinology |volume=145 |issue= 7 |pages= 3095–100 |year= 2004 |pmid= 15117874 |doi= 10.1210/en.2004-0304

External links

* [ IUPHAR GPCR Database - Thyrotropin-releasing hormone receptor]

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