Thyrotropin receptor

Thyrotropin receptor

The thyrotropin receptor (or TSH receptor) is a gene (and associated protein) which responds to thyroid-stimulating hormone (also known as "thyrotropin", and stimulates the production of thyroxine (T4) and triiodothyronine (T3). The TSH receptor is a member of the G-protein coupled receptor superfamily of integral membrane proteins.cite journal | author = Farid NR, Szkudlinski MW | title = Minireview: structural and functional evolution of the thyrotropin receptor | journal = Endocrinology | volume = 145 | issue = 9 | pages = 4048–57 | year = 2004 | pmid = 15231707 | doi = 10.1210/en.2004-0437 | issn = ]

It is primarily found on the surface of the thyroid epithelial cells.

It should not be confused with "thyrotropin-releasing hormone" (Gene|TRH) or "thyrotropin-releasing hormone receptor" (Gene|TRHR).

ee also

* Graves' disease

Further reading

citations =
*cite journal | author=Führer D, Wonerow P, Willgerodt H, Paschke R |title=Identification of a new thyrotropin receptor germline mutation (Leu629Phe) in a family with neonatal onset of autosomal dominant nonautoimmune hyperthyroidism. |journal=J. Clin. Endocrinol. Metab. |volume=82 |issue= 12 |pages= 4234–8 |year= 1998 |pmid= 9398746 |doi=
*cite journal | author=Farid NR, Kascur V, Balazs C |title=The human thyrotropin receptor is highly mutable: a review of gain-of-function mutations. |journal=Eur. J. Endocrinol. |volume=143 |issue= 1 |pages= 25–30 |year= 2000 |pmid= 10870027 |doi=
*cite journal | author=Szkudlinski MW, Fremont V, Ronin C, Weintraub BD |title=Thyroid-stimulating hormone and thyroid-stimulating hormone receptor structure-function relationships. |journal=Physiol. Rev. |volume=82 |issue= 2 |pages= 473–502 |year= 2002 |pmid= 11917095 |doi= 10.1152/physrev.00031.2001
*cite journal | author=Tonacchera M, Vitti P, De Servi M, "et al." |title=Gain of function TSH receptor mutations and iodine deficiency: implications in iodine prophylaxis. |journal=J. Endocrinol. Invest. |volume=26 |issue= 2 Suppl |pages= 2–6 |year= 2004 |pmid= 12762632 |doi=
*cite journal | author=Arturi F, Scarpelli D, Coco A, "et al." |title=Thyrotropin receptor mutations and thyroid hyperfunctioning adenomas ten years after their first discovery: unresolved questions. |journal=Thyroid |volume=13 |issue= 4 |pages= 341–3 |year= 2004 |pmid= 12804102 |doi= 10.1089/105072503321669811
*cite journal | author=Vaidya B, Campbell V, Tripp JH, "et al." |title=Premature birth and low birth weight associated with nonautoimmune hyperthyroidism due to an activating thyrotropin receptor gene mutation. |journal=Clin. Endocrinol. (Oxf) |volume=60 |issue= 6 |pages= 711–8 |year= 2004 |pmid= 15163335 |doi= 10.1111/j.1365-2265.2004.02040.x
*cite journal | author=Takeshita A, Nagayama Y, Fujiyama K, "et al." |title=Molecular cloning and sequencing of an alternatively spliced form of the human thyrotropin receptor transcript. |journal=Biochem. Biophys. Res. Commun. |volume=188 |issue= 3 |pages= 1214–9 |year= 1992 |pmid= 1445355 |doi=
*cite journal | author=Graves PN, Tomer Y, Davies TF |title=Cloning and sequencing of a 1.3 KB variant of human thyrotropin receptor mRNA lacking the transmembrane domain. |journal=Biochem. Biophys. Res. Commun. |volume=187 |issue= 2 |pages= 1135–43 |year= 1992 |pmid= 1530609 |doi=
*cite journal | author=Loosfelt H, Pichon C, Jolivet A, "et al." |title=Two-subunit structure of the human thyrotropin receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 9 |pages= 3765–9 |year= 1992 |pmid= 1570295 |doi=
*cite journal | author=Nagayama Y, Russo D, Wadsworth HL, "et al." |title=Eleven amino acids (Lys-201 to Lys-211) and 9 amino acids (Gly-222 to Leu-230) in the human thyrotropin receptor are involved in ligand binding. |journal=J. Biol. Chem. |volume=266 |issue= 23 |pages= 14926–30 |year= 1991 |pmid= 1651314 |doi=
*cite journal | author=Murakami M, Mori M |title=Identification of immunogenic regions in human thyrotropin receptor for immunoglobulin G of patients with Graves' disease. |journal=Biochem. Biophys. Res. Commun. |volume=171 |issue= 1 |pages= 512–8 |year= 1990 |pmid= 1697467 |doi=
*cite journal | author=Heldin NE, Gustavsson B, Westermark K, Westermark B |title=A somatic point mutation in a putative ligand binding domain of the TSH receptor in a patient with autoimmune hyperthyroidism. |journal=J. Clin. Endocrinol. Metab. |volume=73 |issue= 6 |pages= 1374–6 |year= 1992 |pmid= 1955520 |doi=
*cite journal | author=Libert F, Passage E, Lefort A, "et al." |title=Localization of human thyrotropin receptor gene to chromosome region 14q3 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=54 |issue= 1-2 |pages= 82–3 |year= 1991 |pmid= 2249482 |doi=
*cite journal | author=Frazier AL, Robbins LS, Stork PJ, "et al." |title=Isolation of TSH and LH/CG receptor cDNAs from human thyroid: regulation by tissue specific splicing. |journal=Mol. Endocrinol. |volume=4 |issue= 8 |pages= 1264–76 |year= 1991 |pmid= 2293030 |doi=
*cite journal | author=Misrahi M, Loosfelt H, Atger M, "et al." |title=Cloning, sequencing and expression of human TSH receptor. |journal=Biochem. Biophys. Res. Commun. |volume=166 |issue= 1 |pages= 394–403 |year= 1990 |pmid= 2302212 |doi=
*cite journal | author=Nagayama Y, Kaufman KD, Seto P, Rapoport B |title=Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor. |journal=Biochem. Biophys. Res. Commun. |volume=165 |issue= 3 |pages= 1184–90 |year= 1990 |pmid= 2558651 |doi=
*cite journal | author=Libert F, Lefort A, Gerard C, "et al." |title=Cloning, sequencing and expression of the human thyrotropin (TSH) receptor: evidence for binding of autoantibodies. |journal=Biochem. Biophys. Res. Commun. |volume=165 |issue= 3 |pages= 1250–5 |year= 1990 |pmid= 2610690 |doi=
*cite journal | author=Cuddihy RM, Bryant WP, Bahn RS |title=Normal function in vivo of a homozygotic polymorphism in the human thyrotropin receptor. |journal=Thyroid |volume=5 |issue= 4 |pages= 255–7 |year= 1996 |pmid= 7488864 |doi=
*cite journal | author=Bahn RS, Dutton CM, Heufelder AE, Sarkar G |title=A genomic point mutation in the extracellular domain of the thyrotropin receptor in patients with Graves' ophthalmopathy. |journal=J. Clin. Endocrinol. Metab. |volume=78 |issue= 2 |pages= 256–60 |year= 1994 |pmid= 7508946 |doi=
*cite journal | author=Sunthornthepvarakui T, Gottschalk ME, Hayashi Y, Refetoff S |title=Brief report: resistance to thyrotropin caused by mutations in the thyrotropin-receptor gene. |journal=N. Engl. J. Med. |volume=332 |issue= 3 |pages= 155–60 |year= 1995 |pmid= 7528344 |doi=

External links

* [ IUPHAR GPCR Database - TSH receptor]
* [ GRIS: Glycoprotein-hormone Receptor Information System]


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