- Corticotropin-releasing hormone receptor
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corticotropin releasing hormone receptor 1 Identifiers Symbol CRHR1 Alt. symbols CRHR Entrez 1394 HUGO 2357 OMIM 122561 RefSeq XM_001128344 UniProt P34998 Other data Locus Chr. 17 q12-q22 corticotropin releasing hormone receptor 2 Identifiers Symbol CRHR2 Entrez 1395 HUGO 2358 OMIM 602034 RefSeq NM_001883 UniProt Q13324 Other data Locus Chr. 7 p21-p15 Corticotropin-releasing hormone receptors (CRHRs), also known known as corticotropin-releasing factor receptors (CRFRs) are a G protein-coupled receptor family that binds corticotropin-releasing hormone (CRH).[1] There are two receptors in the family, designated as type I and 2, each encoded by a separate gene (CRHR1 and CRHR2 respectively).
Function
CRHRs are important mediators in the stress response.[2] Cells in the anterior lobe of the pituitary gland known as corticotropes express the receptors and will secrete adrenocorticotropic hormone (ACTH) when stimulated.[3]
References
- ^ Hauger RL, Grigoriadis DE, Dallman MF, Plotsky PM, Vale WW, Dautzenberg FM (2003). "International Union of Pharmacology. XXXVI. Current status of the nomenclature for receptors for corticotropin-releasing factor and their ligands". Pharmacol. Rev. 55 (1): 21–6. doi:10.1124/pr.55.1.3. PMID 12615952.
- ^ Grammatopoulos DK, Chrousos GP (2002). "Functional characteristics of CRH receptors and potential clinical applications of CRH-receptor antagonists". Trends Endocrinol. Metab. 13 (10): 436–44. doi:10.1016/S1043-2760(02)00670-7. PMID 12431840.
- ^ Aguilera G, Wynn PC, Harwood JP, Hauger RL, Millan MA, Grewe C, Catt KJ (1986). "Receptor-mediated actions of corticotropin-releasing factor in pituitary gland and nervous system". Neuroendocrinology 43 (1): 79–88. doi:10.1159/000124513. PMID 3012395.
External links
- "Corticotropin-Releasing Factor Receptors". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1321.
- MeSH Corticotropin-releasing+hormone+receptors
Neuropeptide receptors G protein-coupled receptor OtherOther neuropeptide receptorsAngiotensin · Bradykinin (B1, B2) / Tachykinin (TACR1) · Calcitonin gene-related peptide · Galanin · GPCR neuropeptide (B/W, FF, S, Y) · NeurotensinType I cytokine receptor Enzyme-linked receptor Other B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp) Neuropeptidergics Cholecystokinin Agonists: Cholecystokinin • CCK-4
Antagonists: Asperlicin • Proglumide • Lorglumide • Devazepide • DexloxiglumideCRH Agonists: Corticotropin releasing hormoneGalanin Agonists: Galanin • Galanin-like peptide • Galmic • GalnonAgonists: Galanin • Galanin-like peptide • Galmic • GalnonAgonists: Galanin • Galmic • GalnonGhrelin MCH Agonists: Melanin concentrating hormone
Antagonists: ATC-0175 • GW-803,430 • NGD-4715 • SNAP-7941 • SNAP-94847Agonists: Melanin concentrating hormoneMelanocortin Agonists: alpha-MSH • Afamelanotide • Bremelanotide • Melanotan II
Antagonists: Agouti signalling peptideAgonists: alpha-MSH • Bremelanotide • Melanotan IIAgonists: alpha-MSH • Melanotan IINeuropeptide S Agonists: Neuropeptide S
Antagonists: SHA-68Neuropeptide Y Neurotensin Opioid see Template:OpioidsOrexin Oxytocin Agonists: Carbetocin • Demoxytocin • Oxytocin • WAY-267,464
Antagonists: Atosiban • Epelsiban • L-371,257 • L-368,899Tachykinin Agonists: Substance P
Antagonists: Aprepitant • Befetupitant • Casopitant • CI-1021 • CP-96,345 • CP-99,994 • CP-122,721 • Dapitant • Ezlopitant • FK-888 • Fosaprepitant • GR-203,040 • GW-597,599 • HSP-117 • L-733,060 • L-741,671 • L-743,310 • L-758,298 • Lanepitant • LY-306,740 • Maropitant • Netupitant • NKP-608 • Nolpitantium • Orvepitant • RP-67,580 • SDZ NKT 343 • Vestipitant • VofopitantVasopressin Agonists: Desmopressin • Felypressin • Ornipressin • Terlipressin • Vasopressin
Antagonists: Conivaptan • Demeclocycline • RelcovaptanAgonists: Felypressin • Ornipressin • Terlipressin • Vasopressin
Antagonists: Demeclocycline • NelivaptanAgonists: Desmopressin • Ornipressin • Vasopressin
Antagonists: Conivaptan • Demeclocycline • Lixivaptan • Mozavaptan • Satavaptan • TolvaptanCategories:- Genes on chromosome 17
- Genes on chromosome 7
- Chromosome 17 gene stubs
- Cell biology stubs
- Corticotropin-releasing hormone
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